Identification |
HMDB Protein ID
| CDBP02714 |
Secondary Accession Numbers
| Not Available |
Name
| Voltage-dependent L-type calcium channel subunit beta-1 |
Description
| Not Available |
Synonyms
|
- CAB1
- Calcium channel voltage-dependent subunit beta 1
|
Gene Name
| CACNB1 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in voltage-gated calcium channel activity |
Specific Function
| The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting |
GO Classification
|
Function |
ion transmembrane transporter activity |
transporter activity |
ion channel activity |
cation channel activity |
calcium channel activity |
voltage-gated calcium channel activity |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
Process |
di-, tri-valent inorganic cation transport |
divalent metal ion transport |
calcium ion transport |
establishment of localization |
transport |
ion transport |
cation transport |
|
Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- sarcolemma
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Muscle/Heart Contraction | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000564/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000564/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000564/thumb?image_type=simple) | Not Available | Acebutolol Action Pathway | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000364/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000364/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000364/thumb?image_type=simple) | Not Available | Alprenolol Action Pathway | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000365/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000365/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000365/thumb?image_type=simple) | Not Available | Atenolol Action Pathway | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000366/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000366/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000366/thumb?image_type=simple) | Not Available | Betaxolol Action Pathway | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000367/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000367/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000367/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 17q21-q22 |
SNPs
| CACNB1 |
Gene Sequence
|
>1797 bp
ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATG
GAGGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGG
TCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG
GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCC
TTAAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCA
GTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT
GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATAC
AATAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCC
AGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC
CTCGGCTCCAGCAAATCAGGCGATAACTCCAGTTCCAGTCTGGGAGATGTGGTGACTGGC
ACCCGCCGCCCCACACCCCCTGCCAGTGCCAAACAGAAGCAGAAGTCGACAGAGCATGTG
CCCCCCTATGACGTGGTGCCTTCCATGAGGCCCATCATCCTGGTGGGACCGTCGCTCAAG
GGCTACGAGGTTACAGACATGATGCAGAAAGCTTTATTTGACTTCTTGAAGCATCGGTTT
GATGGCAGGATCTCCATCACTCGTGTGACGGCAGATATTTCCCTGGCTAAGCGCTCAGTT
CTCAACAACCCCAGCAAACACATCATCATTGAGCGCTCCAACACACGCTCCAGCCTGGCT
GAGGTGCAGAGTGAAATCGAGCGAATCTTCGAGCTGGCCCGGACCCTTCAGTTGGTCGCT
CTGGATGCTGACACCATCAATCACCCAGCCCAGCTGTCCAAGACCTCGCTGGCCCCCATC
ATTGTTTACATCAAGATCACCTCTCCCAAGGTACTTCAAAGGCTCATCAAGTCCCGAGGA
AAGTCTCAGTCCAAACACCTCAATGTCCAAATAGCGGCCTCGGAAAAGCTGGCACAGTGC
CCCCCTGAAATGTTTGACATCATCCTGGATGAGAACCAATTGGAGGATGCCTGCGAGCAT
CTGGCGGAGTACTTGGAAGCCTATTGGAAGGCCACACACCCGCCCAGCAGCACGCCACCC
AATCCGCTGCTGAACCGCACCATGGCTACCGCAGCCCTGGCTGCCAGCCCTGCCCCTGTC
TCCAACCTCCAGGGACCCTACCTTGCTTCCGGGGACCAGCCACTGGAACGGGCCACCGGG
GAGCACGCCAGCATGCACGAGTACCCAGGGGAGCTGGGCCAGCCCCCAGGCCTTTACCCC
AGCAGCCACCCACCAGGCCGGGCAGGCACGCTACGGGCACTGTCCCGCCAAGACACTTTT
GATGCCGACACCCCCGGCAGCCGAAACTCTGCCTACACGGAGCTGGGAGACTCATGTGTG
GACATGGAGACTGACCCCTCAGAGGGGCCAGGGCTTGGAGACCCTGCAGGGGGCGGCACG
CCCCCAGCCCGACAGGGATCCTGGGAGGACGAGGAAGAAGACTATGAGGAAGAGCTGACC
GACAACCGGAACCGGGGCCGGAATAAGGCCCGCTACTGCGCTGAGGGTGGGGGTCCAGTT
TTGGGGCGCAACAAGAATGAGCTGGAGGGCTGGGGACGAGGCGTCTACATTCGCTGA
|
Protein Properties |
Number of Residues
| 598 |
Molecular Weight
| 65713.0 |
Theoretical pI
| 6.75 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Voltage-dependent L-type calcium channel subunit beta-1
MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSA
ESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVP
VQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR
LGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLK
GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA
EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG
KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP
NPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYP
SSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGT
PPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
|
External Links |
GenBank ID Protein
| 12483680 |
UniProtKB/Swiss-Prot ID
| Q02641 |
UniProtKB/Swiss-Prot Entry Name
| CACB1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB054985 |
GeneCard ID
| CACNB1 |
GenAtlas ID
| CACNB1 |
HGNC ID
| HGNC:1401 |
References |
General References
| Not Available |