Identification |
HMDB Protein ID
| CDBP02292 |
Secondary Accession Numbers
| Not Available |
Name
| Equilibrative nucleoside transporter 2 |
Description
| Not Available |
Synonyms
|
- 36 kDa nucleolar protein HNP36
- Delayed-early response protein 12
- Equilibrative NBMPR-insensitive nucleoside transporter
- Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
- Hydrophobic nucleolar protein, 36 kDa
- Nucleoside transporter, ei-type
- Solute carrier family 29 member 2
|
Gene Name
| SLC29A2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleoside transmembrane transporter activity |
Specific Function
| Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine |
GO Classification
|
Component |
membrane |
cell part |
Function |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity |
nucleoside transmembrane transporter activity |
transporter activity |
Process |
establishment of localization |
transport |
|
Cellular Location
|
- Multi-pass membrane protein
- Isoform 2:Nucleus membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Mercaptopurine Action Pathway | | Not Available | Mercaptopurine Metabolism Pathway | | Not Available | Thioguanine Action Pathway | | Not Available | Azathioprine Action Pathway | | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 11q13 |
SNPs
| SLC29A2 |
Gene Sequence
|
>1371 bp
ATGGCCCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTAT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA
|
Protein Properties |
Number of Residues
| 456 |
Molecular Weight
| 50112.3 |
Theoretical pI
| 6.02 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["13-33", "70-90", "99-119", "124-144", "162-182", "193-213", "291-311", "324-344", "360-380", "386-406", "432-452"]
|
Protein Sequence
|
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
|
External Links |
GenBank ID Protein
| 2754821 |
UniProtKB/Swiss-Prot ID
| Q14542 |
UniProtKB/Swiss-Prot Entry Name
| S29A2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF029358 |
GeneCard ID
| SLC29A2 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |