| Identification |
|---|
| HMDB Protein ID
| CDBP03423 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gamma-aminobutyric acid receptor subunit gamma-1 |
| Description
| Not Available |
| Synonyms
|
- GABA(A) receptor subunit gamma-1
|
| Gene Name
| GABRG1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in ion transport |
| Specific Function
| GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| postsynaptic membrane |
| Function |
| gaba receptor activity |
| gaba-a receptor activity |
| transporter activity |
| ion channel activity |
| ligand-gated ion channel activity |
| extracellular ligand-gated ion channel activity |
| receptor activity |
| transmembrane receptor activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| molecular transducer activity |
| signal transducer activity |
| Process |
| ion transport |
| establishment of localization |
| transport |
| gamma-aminobutyric acid signaling pathway |
| chloride transport |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| anion transport |
| g-protein coupled receptor protein signaling pathway |
| inorganic anion transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Cell junction
- synapse
- postsynaptic cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4p12 |
| SNPs
| GABRG1 |
| Gene Sequence
|
>1398 bp
ATGGGTCCTTTGAAAGCTTTTCTCTTCTCCCCTTTTCTTCTGCGGAGTCAAAGTAGAGGG
GTGAGGTTGGTCTTCTTGTTACTGACCCTGCATTTGGGAAACTGTGTTGATAAGGCAGAT
GATGAAGATGATGAGGATTTAACGGTGAACAAAACCTGGGTCTTGGCCCCAAAAATTCAT
GAAGGAGATATCACACAAATTCTGAATTCATTGCTTCAAGGCTATGACAATAAACTTCGT
CCAGATATAGGAGTGAGGCCCACAGTAATTGAAACTGATGTTTATGTAAACAGCATTGGA
CCAGTTGATCCAATTAATATGGAATATACAATAGATATAATTTTTGCCCAAACCTGGTTT
GACAGTCGTTTAAAATTCAATAGTACCATGAAAGTGCTTATGCTTAACAGTAATATGGTT
GGAAAAATTTGGATTCCTGACACTTTCTTCAGAAACTCAAGAAAATCTGATGCTCACTGG
ATAACAACTCCTAATCGTCTGCTTCGAATTTGGAATGATGGACGAGTTCTGTATACTCTA
AGATTGACAATTAATGCAGAATGTTATCTTCAGCTTCATAACTTTCCCATGGATGAACAT
TCCTGTCCACTGGAATTTTCAAGCTATGGATACCCTAAAAATGAAATTGAGTATAAGTGG
AAAAAGCCCTCCGTAGAAGTGGCTGATCCTAAATACTGGAGATTATATCAGTTTGCATTT
GTAGGGTTACGGAACTCAACTGAAATCACTCACACGATCTCTGGGGATTATGTTATCATG
ACAATTTTTTTTGACCTGAGCAGAAGAATGGGATATTTCACTATTCAGACCTACATTCCA
TGCATTCTGACAGTTGTTCTTTCTTGGGTGTCTTTTTGGATCAATAAAGATGCAGTGCCT
GCAAGAACATCGTTGGGTATCACTACAGTTCTGACTATGACAACCCTGAGTACAATTGCC
AGGAAGTCTTTACCTAAGGTTTCTTATGTGACTGCGATGGATCTCTTTGTTTCTGTTTGT
TTCATTTTTGTTTTTGCAGCCTTGATGGAATATGGAACCTTGCATTATTTTACCAGCAAC
CAAAAAGGAAAGACTGCTACTAAAGACAGAAAGCTAAAAAATAAAGCCTCGATGACTCCT
GGTCTCCATCCTGGATCCACTCTGATTCCAATGAATAATATTTCTGTGCCGCAAGAAGAT
GATTATGGGTATCAGTGTTTGGAGGGCAAAGATTGTGCCAGCTTCTTCTGTTGCTTTGAA
GACTGCAGAACAGGATCTTGGAGGGAAGGAAGGATACACATACGCATTGCCAAAATTGAC
TCTTATTCTAGAATATTTTTCCCAACCGCTTTTGCCCTGTTCAACTTGGTTTATTGGGTT
GGCTATCTTTACTTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 465 |
| Molecular Weight
| 53594.5 |
| Theoretical pI
| 8.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["273-294", "299-320", "332-354", "445-465"]
|
| Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit gamma-1
MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH
EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL
RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE
DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8N1C3 |
| UniProtKB/Swiss-Prot Entry Name
| GBRG1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK122845 |
| GeneCard ID
| GABRG1 |
| GenAtlas ID
| GABRG1 |
| HGNC ID
| HGNC:4086 |
| References |
|---|
| General References
| Not Available |