Cannabis Compound Database: Showing Protein 5-hydroxytryptamine receptor 3B (CDBP04860)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04860

Secondary Accession Numbers

Not Available

Name

5-hydroxytryptamine receptor 3B

Description

Not Available

Synonyms

5-HT3-B
5-HT3B
Serotonin receptor 3B

Gene Name

HTR3B

Protein Type

Receptor

Biological Properties

General Function

Involved in extracellular ligand-gated ion channel activity

Specific Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

GO Classification

Component
membrane part
intrinsic to membrane
integral to membrane
postsynaptic membrane
membrane
cell part
Function
ligand-gated ion channel activity
extracellular ligand-gated ion channel activity
receptor activity
transmembrane receptor activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
molecular transducer activity
signal transducer activity
transporter activity
serotonin receptor activity
g-protein coupled receptor activity
g-protein coupled amine receptor activity
ion channel activity
Process
establishment of localization
transport
ion transport

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11q23.1

SNPs

HTR3B

Gene Sequence

>1326 bp
ATGTTGTCAAGTGTAATGGCTCCCCTGTGGGCCTGCATCCTGGTGGCTGCAGGAATTCTA
GCCACAGATACACATCATCCCCAGGATTCTGCTCTGTATCATCTCAGCAAGCAGCTATTA
CAGAAATATCATAAAGAAGTGAGACCTGTTTACAACTGGACCAAGGCCACCACAGTCTAC
CTGGACCTGTTCGTCCATGCTATATTGGATGTGGATGCAGAGAATCAAATATTAAAGACA
AGTGTATGGTACCAAGAGGTCTGGAATGATGAATTTTTATCCTGGAACTCCAGCATGTTT
GATGAGATTAGAGAGATCTCCCTACCTCTAAGTGCCATCTGGGCCCCCGATATCATCATC
AATGAGTTTGTGGACATTGAAAGATACCCTGACCTTCCCTATGTTTATGTGAACTCATCT
GGGACCATTGAGAACTATAAGCCCATCCAGGTGGTCTCTGCGTGCAGTTTAGAGACATAT
GCTTTTCCATTTGATGTCCAGAATTGCAGCCTGACCTTCAAGAGCATTCTGCATACAGTG
GAAGACGTAGACCTGGCCTTTCTGAGGAGCCCAGAAGACATTCAGCATGACAAAAAGGCG
TTTTTGAATGACAGTGAGTGGGAACTTCTATCTGTGTCCTCCACATACAGCATCCTGCAG
AGCAGCGCTGGAGGATTTGCACAGATTCAGTTTAATGTGGTGATGCGCAGGCACCCCCTG
GTCTATGTCGTGAGTCTGCTGATTCCTAGCATCTTTCTCATGCTGGTGGACCTGGGGAGC
TTCTACCTGCCACCCAACTGCCGAGCCAGGATTGTGTTCAAGACCAGTGTGCTGGTGGGC
TACACCGTCTTCAGGGTCAACATGTCCAACCAGGTGCCACGGAGTGTAGGGAGCACCCCT
CTGATTGGGCACTTCTTCACCATCTGCATGGCCTTCTTGGTTCTCAGCTTAGCTAAGTCC
ATCGTGTTGGTCAAATTCCTCCATGATGAGCAGCGTGGTGGACAGGAGCAGCCCTTCTTG
TGCCTTCGAGGGGACACCGATGCTGACAGGCCTAGAGTGGAACCCAGGGCCCAACGTGCT
GTGGTAACAGAGTCCTCGCTGTATGGAGAGCACCTGGCCCAGCCAGGAACCCTGAAGGAA
GTCTGGTCGCAGCTTCAATCTATCAGCAACTACCTCCAAACTCAGGACCAGACAGACCAA
CAGGAGGCAGAGTGGCTGGTCCTCCTGTCCCGCTTTGACCGACTGCTCTTCCAAAGCTAC
CTTTTCATGCTGGGGATCTACACCATCACTCTGTGCTCCCTCTGGGCACTGTGGGGCGGC
GTGTGA

Protein Properties

Number of Residues

441

Molecular Weight

50291.3

Theoretical pI

4.99

Pfam Domain Function

Neur_chan_LBD (PF02931 )
Neur_chan_memb (PF02932 )

Signals

["1-21"]

Transmembrane Regions

["239-259", "269-286", "304-324", "415-435"]

Protein Sequence

>5-hydroxytryptamine receptor 3B
MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL
VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP
LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA
VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY
LFMLGIYTITLCSLWALWGGV

External Links

GenBank ID Protein

4218949

UniProtKB/Swiss-Prot ID

O95264

UniProtKB/Swiss-Prot Entry Name

5HT3B_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF080582

GeneCard ID