Cannabis Compound Database: Showing Compound Card for L-Glutamic acid (CDB000130)

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Record Information

Version

1.0

Created at

2020-03-18 23:25:53 UTC

Updated at

2022-12-13 23:36:24 UTC

CannabisDB ID

CDB000130

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Glutamic acid

Description

L-glutamic acid (abbreviated Glu or E), also referred to as glutamate (the anion), is a non-essential amino acid, one of the 20 amino acids used in the biosynthesis of proteins. L-glutamic acid exists in all living species, from bacteria to humans. In humans, dietary proteins are broken down by digestion into amino acids, which serves as metabolic fuel or other functional roles in the body. Glutamate is a component amino acid in many protein rich foods including the gluten protein in flour and is found as a free acid in cheeses and soya sauce. It is used as a flavor enhancer as a sodium salt known as monosodium glutamate. As a proteinogenic amino acid, L-glutamic acid is also found in Cannabis plants (PMID: 6991645 ). Glutamate is a key molecule in cellular metabolism. Glutamate is the most abundant fast excitatory neurotransmitter in the mammalian nervous system. At chemical synapses, glutamate is stored in vesicles. Nerve impulses trigger release of glutamate from the pre-synaptic cell. In the opposing post-synaptic cell, glutamate receptors, such as the N-methyl-d-aspartate acid (NMDA) receptor, bind glutamate and are activated. Because of its role in synaptic plasticity, it is believed that glutamic acid is involved in cognitive functions like learning and memory in the brain. Glutamate transporters are found in neuronal and glial membranes. They rapidly remove glutamate from the extracellular space. In brain injury or disease, glutamate can accumulate outside cells, causing glutamate excitotoxicity. Excitotoxicity¬†occurs when neurons are exposed to high levels of glutamate or other neurotransmitters, causing persistent activation of the and Œ±-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptors and voltage-gated calcium channels. This results in a lethal influx of extracellular calcium leading to neuronal damage and eventual cell death. Cell death arises from damage to mitochondria by the excessively high intracellular calcium, which open mitochondrial pores, causing mitochondria to swell. Reactive oxygen species (ROS) may also be released by mitochondria into the intracellular space. Excess glutamate and calcium trigger apoptosis by further activating transcription factors for pro-apoptotic genes, or downregulating transcription factors for anti-apoptotic genes. Glutamate excitotoxicity causes other health consequences. In ischemic stroke and brain trauma, the severely reduced blood supply leads to flooding of glutamate and aspartate into the extra-neuronal space ( PMID: 16314180 ). Glutamate excitotoxicity is associated with diseases like amyotrophic lateral sclerosis, multiple sclerosis, lathyrism, and Alzheimer's disease (PMID: 20229265 ) and in epileptic seizures. Microinjection of glutamic acid into neurons produces spontaneous depolarization around one second apart which is like a paroxysmal depolarizing shift seen in epileptic attacks. This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage activated calcium channels, leading to glutamic acid release and further depolarization. Moreover, glutamic acid is associated with N-acetylglutamate synthetase deficiency, which is an inborn error of metabolism.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
(S)-2-Aminopentanedioic acid	ChEBI
(S)-Glutamic acid	ChEBI
Acide glutamique	ChEBI
Acido glutamico	ChEBI
Acidum glutamicum	ChEBI
E	ChEBI
Glu	ChEBI
Glutamate	ChEBI
GLUTAMIC ACID	ChEBI
L-Glu	ChEBI
L-Glutaminic acid	ChEBI
L-Glutaminsaeure	ChEBI
(S)-2-Aminopentanedioate	Generator
(S)-Glutamate	Generator
L-Glutaminate	Generator
L-Glutamate	Generator
(2S)-2-Aminopentanedioate	HMDB
(2S)-2-Aminopentanedioic acid	HMDB
(S)-(+)-Glutamate	HMDB
(S)-(+)-Glutamic acid	HMDB
1-Amino-propane-1,3-dicarboxylate	HMDB
1-Amino-propane-1,3-dicarboxylic acid	HMDB
1-Aminopropane-1,3-dicarboxylate	HMDB
1-Aminopropane-1,3-dicarboxylic acid	HMDB
2-Aminoglutarate	HMDB
2-Aminoglutaric acid	HMDB
2-Aminopentanedioate	HMDB
2-Aminopentanedioic acid	HMDB
a-Aminoglutarate	HMDB
a-Aminoglutaric acid	HMDB
a-Glutamate	HMDB
a-Glutamic acid	HMDB
Aciglut	HMDB
alpha-Aminoglutarate	HMDB
alpha-Aminoglutaric acid	HMDB
alpha-Glutamate	HMDB
alpha-Glutamic acid	HMDB
Aminoglutarate	HMDB
Aminoglutaric acid	HMDB
Glt	HMDB
Glusate	HMDB
Glut	HMDB
Glutacid	HMDB
Glutamicol	HMDB
Glutamidex	HMDB
Glutaminate	HMDB
Glutaminic acid	HMDB
Glutaminol	HMDB
Glutaton	HMDB
L-(+)-Glutamate	HMDB
L-(+)-Glutamic acid	HMDB
L-a-Aminoglutarate	HMDB
L-a-Aminoglutaric acid	HMDB
L-alpha-Aminoglutarate	HMDB
L-alpha-Aminoglutaric acid	HMDB
D Glutamate	HMDB
Glutamate, potassium	HMDB
Glutamic acid, (D)-isomer	HMDB
L Glutamic acid	HMDB
D-Glutamate	HMDB
L Glutamate	HMDB
Aluminum L glutamate	HMDB
Aluminum L-glutamate	HMDB
L-Glutamate, aluminum	HMDB
Potassium glutamate	HMDB
2-Acetamido-2-deoxy-D-glucose	HMDB
D-GlcNAc	HMDB
N-Acetyl-D-glucosamine	HMDB
N-Acetylchitosamine	HMDB
N Acetyl D glucosamine	HMDB
2 Acetamido 2 deoxy D glucose	HMDB
2 Acetamido 2 deoxyglucose	HMDB
2-Acetamido-2-deoxyglucose	HMDB
Acetylglucosamine	HMDB
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine	HMDB
N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine	HMDB
N-Choloylglycine	HMDB
3a,7a,12a-Trihydroxy-5b-cholan-24-oylglycine	HMDB
3Α,7α,12α-trihydroxy-5β-cholan-24-oylglycine	HMDB
N-[(3a,5b,7a,12a)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine	HMDB
N-[(3Α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine	HMDB
Glycocholate	HMDB
Glycine cholate	HMDB
Glycocholic acid, sodium salt	HMDB
Cholylglycine	HMDB
Glycocholate sodium	HMDB
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid-24-glycine	HMDB
3alpha,7alpha,12alpha-Trihydroxy-N-(carboxymethyl)-5beta-cholan-24-amide	HMDB
3Α,7α,12α-trihydroxy-5β-cholanic acid-24-glycine	HMDB
3Α,7α,12α-trihydroxy-N-(carboxymethyl)-5β-cholan-24-amide	HMDB
Glycoreductodehydrocholic acid	HMDB
Glycylcholate	HMDB
Glycylcholic acid	HMDB
N-(Carboxymethyl)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-amide	HMDB
N-(Carboxymethyl)-3α,7α,12α-trihydroxy-5β-cholan-24-amide	HMDB
N-Choloyl-glycine	HMDB
3-Hydroxy-1,3,5(10)-estratrien-17-one	HMDB
Follicular hormone	HMDB
Folliculin	HMDB
Oestrone	HMDB
(+)-Estrone	HMDB
1,3,5(10)-Estratrien-3-ol-17-one	HMDB
3-Hydroxy-17-keto-estra-1,3,5-triene	HMDB
3-Hydroxyestra-1,3,5(10)-trien-17-one	HMDB
3-Hydroxyestra-1,3,5(10)-triene-17-one	HMDB
3-Hydroxyoestra-1,3,5(10)-trien-17-one	HMDB
D1,3,5(10)-Estratrien-3-ol-17-one	HMDB
Estrone, (+-)-isomer	HMDB
Hyrex brand OF estrone	HMDB
Estrone, (9 beta)-isomer	HMDB
Estrovarin	HMDB
Kestrone	HMDB
Wehgen	HMDB
Estrone, (8 alpha)-isomer	HMDB
Hauck brand OF estrone	HMDB
Unigen	HMDB
Vortech brand OF estrone	HMDB
alpha,beta-Hydroxypropionic acid	HMDB
D-GroA	HMDB
R-Glyceric acid	HMDB
Glycerate	HMDB
(R)-Glycerate	HMDB
a,b-Hydroxypropionate	HMDB
a,b-Hydroxypropionic acid	HMDB
alpha,beta-Hydroxypropionate	HMDB
Α,β-hydroxypropionate	HMDB
Α,β-hydroxypropionic acid	HMDB
R-Glycerate	HMDB
(R)-Glyceric acid	HMDB
D-Glycerate	HMDB
D-Glyceric acid	HMDB
(2R)-2,3-Dihydroxypropanoic acid	HMDB
(R)-2,3-Dihydroxypropanoic acid	HMDB
D-2,3-Dihydroxypropanoic acid	HMDB
1-Amino-2-hydroxyethane	HMDB
2-Amino-1-ethanol	HMDB
2-Amino-ethanol	HMDB
2-Aminoethan-1-ol	HMDB
2-Aminoethyl alcohol	HMDB
2-Hydroxyethylamine	HMDB
Aethanolamin	HMDB
Aminoethanol	HMDB
beta-Aminoethanol	HMDB
beta-Aminoethyl alcohol	HMDB
beta-Ethanolamine	HMDB
beta-Hydroxyethylamine	HMDB
Colamine	HMDB
ETA	HMDB
Glycinol	HMDB
Hea	HMDB
MEA	HMDB
MONOETHANOLAMINE	HMDB
b-Aminoethanol	HMDB
Β-aminoethanol	HMDB
b-Aminoethyl alcohol	HMDB
Β-aminoethyl alcohol	HMDB
b-Ethanolamine	HMDB
Β-ethanolamine	HMDB
b-Hydroxyethylamine	HMDB
Β-hydroxyethylamine	HMDB
2-Aminoethanol	HMDB
2-Ethanolamine	HMDB
2-Hydroxyethanamine	HMDB
Envision conditioner PDD 9020	HMDB
Ethylolamine	HMDB
H-Glycinol	HMDB
Monoaethanolamin	HMDB
Olamine	HMDB
2 Aminoethanol	HMDB
(3R,4S,5R)-5-[(1R)-1-Carboxy-2,2-difluoro-1-(phosphonooxy)ethoxy]-4-hydroxy-3-(phosphonooxy)cyclohex-1-ene-1-carboxylate	HMDB
(1S)-2-[(3-O-b-D-Glucopyranosyl-b-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoate	HMDB
(1S)-2-[(3-O-b-D-Glucopyranosyl-b-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid	HMDB
(1S)-2-[(3-O-beta-D-Glucopyranosyl-beta-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid	HMDB
(1S)-2-[(3-O-Β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoate	HMDB
(1S)-2-[(3-O-Β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid	HMDB

Chemical Formula

C₅H₉NO₄

Average Molecular Weight

147.13

Monoisotopic Molecular Weight

147.0532

IUPAC Name

(2S)-2-aminopentanedioic acid

Traditional Name

L-glutamic acid

CAS Registry Number

56-86-0

SMILES

N[C@@H](CCC(O)=O)C(O)=O

InChI Identifier

InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI Key

WHUUTDBJXJRKMK-VKHMYHEASA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Glutamic acid and derivatives

Alternative Parents

Substituents

Glutamic acid or derivatives
Alpha-amino acid
L-alpha-amino acid
Amino fatty acid
Dicarboxylic acid or derivatives
Fatty acid
Fatty acyl
Amino acid
Carboxylic acid
Organic oxide
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organopnictogen compound
Carbonyl group
Organic oxygen compound
Amine
Organic nitrogen compound
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:16015 )
L-alpha-amino acid (CHEBI:16015 )
glutamic acid (CHEBI:16015 )
glutamine family amino acid (CHEBI:16015 )
Common amino acids (C00025 )
Amino acids (C00025 )

Ontology

Heart failure

Cancer:

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Neurotransmitter

Industrial application:

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	8.57 mg/mL	Not Available
logP	-3.69	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-3.5	ALOGPS
logP	-3.2	ChemAxon
logS	-0.26	ALOGPS
pKa (Strongest Acidic)	1.88	ChemAxon
pKa (Strongest Basic)	9.54	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	100.62 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	31.29 m³·mol⁻¹	ChemAxon
Polarizability	13.32 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Glutamic acid, 3 TMS, GC-MS Spectrum	splash10-0002-2950000000-2d6edc93ec5f8dee2223	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-002b-0940000000-4e285988bc537825d94d	Spectrum
GC-MS	L-Glutamic acid, 3 TMS, GC-MS Spectrum	splash10-00dj-9630000000-1ecc76aab86283892139	Spectrum
GC-MS	L-Glutamic acid, 2 TMS, GC-MS Spectrum	splash10-001i-8910000000-00f65ced0c55aa4ad169	Spectrum
GC-MS	L-Glutamic acid, 3 TMS, GC-MS Spectrum	splash10-0032-3980000000-3069de5b6c49e4176968	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-0002-0790000000-79d3e289c22cb183faa1	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-0002-2950000000-2d6edc93ec5f8dee2223	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-002b-0940000000-4e285988bc537825d94d	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-00ea-6932100000-30d3f5dcc198a5971e96	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-00dj-9630000000-1ecc76aab86283892139	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-001i-8910000000-00f65ced0c55aa4ad169	Spectrum
GC-MS	L-Glutamic acid, non-derivatized, GC-MS Spectrum	splash10-0032-3980000000-3069de5b6c49e4176968	Spectrum
Predicted GC-MS	L-Glutamic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0znc-9300000000-f88e86b78a4cee99a2d4	Spectrum
Predicted GC-MS	L-Glutamic acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00di-8290000000-f99e03763f636e557887	Spectrum
Predicted GC-MS	L-Glutamic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Glutamic acid, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-003r-6900000000-95b0a084dc076f9c7b91	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-9000000000-c37d4c80a14ec029ef63	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0a59-9000000000-6f1888aa71bcb0adf76c	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004j-0900000000-5fa8a338dcd2f2a6bdd2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0900000000-16763200aa07f7629ad4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-03di-3900000000-d9cfc5187aa799f6f978	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-10ee9a593e13550bec1c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0900000000-4d045a3c1fc6e56f801b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-9000000000-c3c7f8f3754109a0c25b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0900000000-48bfae26c69408b7f0ae	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0900000000-82c2a681e7522a7bb1d1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0905010000-af1c9ec4d0062fa6960e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-01q9-9700000000-2b967b896a6e48914512	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0900000000-1434321646181ea894a0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0900000000-11fadb2530828eedad8a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-006t-0941100000-07d051890cb1d9e5c856	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-9200000000-f8619d11f1f54d836bb1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0900000000-ea2dd00e79ef06e8dc04	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0900000000-3e239d4014c95a2ef873	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0900000000-b548959edce39d319cf4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0udi-0900000000-40d901f655797db2cd0f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0udi-1900000000-f997527a39900ac431c7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0udi-7900000000-60816f0601a4e6d25ffb	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0007-9000000000-6ee821f657c604d1afca	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-000t-0900000000-7c02624abe56da9247a2	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Alanine Metabolism
Histidine Metabolism
Malate-Aspartate Shuttle		Not Available
Ammonia Recycling
Cysteine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	1p36	P30038	details
Glutathione reductase, mitochondrial	GSR	8p21.1	P00390	details
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	GFPT2	5q34-q35	O94808	details
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	GFPT1	2p13	Q06210	details
4-aminobutyrate aminotransferase, mitochondrial	ABAT	16p13.2	P80404	details
Tyrosine aminotransferase	TAT	16q22.1	P17735	details
Aspartate aminotransferase, cytoplasmic	GOT1	10q24.1-q25.1	P17174	details
Aspartate aminotransferase, mitochondrial	GOT2	16q21	P00505	details
Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	12p12.1	P54687	details
Amidophosphoribosyltransferase	PPAT	4q12	Q06203	details
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	AADAT	4q33	Q8N5Z0	details
Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	5p13	Q9BYV1	details
Ornithine aminotransferase, mitochondrial	OAT	10q26	P04181	details
Kynurenine--oxoglutarate transaminase 1	CCBL1	9q34.11	Q16773	details
Glutamate--cysteine ligase catalytic subunit	GCLC	6p12	P48506	details
Glutamate--cysteine ligase regulatory subunit	GCLM	1p22.1	P48507	details
N-acetylglutamate synthase, mitochondrial	NAGS	17q21.31	Q8N159	details
Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	19q13	O15382	details
Bifunctional glutamate/proline--tRNA ligase	EPRS	1q41	P07814	details
Asparagine synthetase [glutamine-hydrolyzing]	ASNS	7q21.3	P08243	details
GMP synthase [glutamine-hydrolyzing]	GMPS	3q24	P49915	details
Glutamate dehydrogenase 2, mitochondrial	GLUD2	Xq24-q25	P49448	details
Glutamine synthetase	GLUL	1q31	P15104	details
Glutaminase liver isoform, mitochondrial	GLS2	12q13	Q9UI32	details
CTP synthase 1	CTPS1	1p34.1	P17812	details
Glutaminase kidney isoform, mitochondrial	GLS	2q32-q34	O94925	details
Formimidoyltransferase-cyclodeaminase	FTCD	21q22.3	O95954	details
Glutamate dehydrogenase 1, mitochondrial	GLUD1	10q23.3	P00367	details
Glutamate decarboxylase 2	GAD2	10p11.23	Q05329	details
Glutamate decarboxylase 1	GAD1	2q31	Q99259	details
Gamma-glutamyltranspeptidase 1	GGT1	22q11.23	P19440	details
Gamma-glutamyltransferase 7	GGT7	20q11.22	Q9UJ14	details
Serine--pyruvate aminotransferase	AGXT	2q37.3	P21549	details
Glutathione synthetase	GSS	20q11.2	P48637	details
Folylpolyglutamate synthase, mitochondrial	FPGS	9q34.1	Q05932	details
Alanine aminotransferase 1	GPT	8q24.3	P24298	details
Phosphoserine aminotransferase	PSAT1	9q21.2	Q9Y617	details
Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	7q31.3	Q9UDR5	details
Phosphoribosylformylglycinamidine synthase	PFAS	17p13.1	O15067	details
Delta-1-pyrroline-5-carboxylate synthase	ALDH18A1	10q24.3	P54886	details
5-oxoprolinase	OPLAH	8q24.3	O14841	details
Vitamin K-dependent gamma-carboxylase	GGCX	2p12	P38435	details
Glutamate receptor, ionotropic kainate 1	GRIK1	21q22.11	P39086	details
Glutamate receptor, ionotropic kainate 3	GRIK3	1p34-p33	Q13003	details
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112	4q31.3	O75879	details
Glutamate carboxypeptidase 2	FOLH1	11p11.2	Q04609	details
Arginine decarboxylase	ADC	1p35.1	Q96A70	details
Glutamate receptor 1	GRIA1	5q33\|5q31.1	P42261	details
Aminoadipate aminotransferase, isoform CRA_b	AADAT	4q33	Q4W5N8	details
Mitochondrial glutamate carrier 2	SLC25A18	22q11.2	Q9H1K4	details
Glutamine-dependent NAD(+) synthetase	NADSYN1	11q13.4	Q6IA69	details
Alanine aminotransferase 2	GPT2	16q12.1	Q8TD30	details
Lengsin	LGSN	6pter-q22.33	Q5TDP6	details
CTP synthase 2	CTPS2	Xp22	Q9NRF8	details
Mitochondrial glutamate carrier 1	SLC25A22	11p15.5	Q9H936	details
Gamma-glutamyltransferase 6	GGT6	17p13.2	Q6P531	details
Probable glutamate--tRNA ligase, mitochondrial	EARS2	16p12.2	Q5JPH6	details
Aminoadipate-semialdehyde synthase	AASS	7q31.3	A4D0W4	details
N-acetylaspartyl-glutamate synthetase A	RIMKLA	1p34.2	Q8IXN7	details
Beta-citryl-glutamate synthase B	RIMKLB	12p13.31	Q9ULI2	details
Putative aspartate aminotransferase, cytoplasmic 2	GOT1L1	8p11.23	Q8NHS2	details
Kynurenine--oxoglutarate transaminase 3	CCBL2	1p22.2	Q6YP21	details
Aspartate aminotransferase	GIG18		Q2TU84	details
GGT7 protein	GGT7	20q11.22	A0PJJ9	details
Gamma-glutamyltransferase 5	GGT5	22q11.23	P36269	details
Glutamyl aminopeptidase	ENPEP	4q25	Q07075	details
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial	QRSL1	6q21	Q9H0R6	details
Aspartyl aminopeptidase	DNPEP	2q35	Q9ULA0	details
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial	GATC	12q24.31	O43716	details
Gamma-glutamyltranspeptidase 2	GGT2		P36268	details
Putative gamma-glutamyltranspeptidase 3	GGT3P		A6NGU5	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 1	SLC16A1	1p12	P53985	details
Glutamate [NMDA] receptor subunit zeta-1	GRIN1	9q34.3	Q05586	details
Glutamate [NMDA] receptor subunit 3B	GRIN3B	19p13.3	O60391	details
Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	16p13.2	Q12879	details
Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	17q25	Q14957	details
Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	12p12	Q13224	details
Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	19q13.1-qter	O15399	details
Glutamate receptor, ionotropic kainate 1	GRIK1	21q22.11	P39086	details
Glutamate receptor, ionotropic kainate 2	GRIK2	6q16.3-q21	Q13002	details
Glutamate receptor, ionotropic kainate 3	GRIK3	1p34-p33	Q13003	details
Glutamate receptor 1	GRIA1	5q33\|5q31.1	P42261	details
Cystine/glutamate transporter	SLC7A11	4q28-q32	Q9UPY5	details
Excitatory amino acid transporter 3	SLC1A1	9p24	P43005	details
Excitatory amino acid transporter 1	SLC1A3	5p13	P43003	details
Excitatory amino acid transporter 2	SLC1A2	11p13-p12	P43004	details
Excitatory amino acid transporter 5	SLC1A7	1p32.3	O00341	details
Excitatory amino acid transporter 4	SLC1A6	19p13.12	P48664	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details
Mitochondrial glutamate carrier 1	SLC25A22	11p15.5	Q9H936	details
Glutamate receptor 2	GRIA2	4q32-q33	P42262	details
Glutamate [NMDA] receptor subunit 3A	GRIN3A	9q31.1	Q8TCU5	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Amidophosphoribosyltransferase	PPAT	4q12	Q06203	details
CAD protein	CAD	2p22-p21	P27708	details
N-acetylaspartyl-glutamate synthetase A	RIMKLA	1p34.2	Q8IXN7	details
Beta-citryl-glutamate synthase B	RIMKLB	12p13.31	Q9ULI2	details
Glutamyl aminopeptidase	ENPEP	4q25	Q07075	details
Aspartyl aminopeptidase	DNPEP	2q35	Q9ULA0	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Glutamate [NMDA] receptor subunit zeta-1	GRIN1	9q34.3	Q05586	details
Glutamate [NMDA] receptor subunit 3B	GRIN3B	19p13.3	O60391	details
Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	16p13.2	Q12879	details
Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	17q25	Q14957	details
Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	12p12	Q13224	details
Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	19q13.1-qter	O15399	details
Glutamate receptor, ionotropic kainate 1	GRIK1	21q22.11	P39086	details
Glutamate receptor, ionotropic kainate 2	GRIK2	6q16.3-q21	Q13002	details
Glutamate receptor, ionotropic kainate 3	GRIK3	1p34-p33	Q13003	details
Metabotropic glutamate receptor 1	GRM1	6q24	Q13255	details
Glutamate receptor 1	GRIA1	5q33\|5q31.1	P42261	details
Glutamate receptor 2	GRIA2	4q32-q33	P42262	details
Glutamate [NMDA] receptor subunit 3A	GRIN3A	9q31.1	Q8TCU5	details
Taste receptor type 1 member 3	TAS1R3	1p36.33	Q7RTX0	details
Metabotropic glutamate receptor 8	GRM8	7q31.3-q32.1	O00222	details
Metabotropic glutamate receptor 4	GRM4	6p21.3	Q14833	details
Metabotropic glutamate receptor 7	GRM7	3p26.1-p25.1	Q14831	details
Glutamate receptor 3	GRIA3	Xq25-q26	P42263	details
Glutamate receptor 4	GRIA4	11q22	P48058	details
Taste receptor type 1 member 1	TAS1R1	1p36.31	Q7RTX1	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Glutamate--cysteine ligase catalytic subunit	GCLC	6p12	P48506	details

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.516 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.521 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.225 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.552 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.222 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.259 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000148

DrugBank ID

DB00142

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB012535

KNApSAcK ID

C00001358

Chemspider ID

Not Available

KEGG Compound ID

C00025

BioCyc ID

GLT

BiGG ID

Not Available

Wikipedia Link

L-Glutamic_Acid

METLIN ID

Not Available

PubChem Compound

33032

PDB ID

Not Available

ChEBI ID

16015

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
Camacho A, Massieu L: Role of glutamate transporters in the clearance and release of glutamate during ischemia and its relation to neuronal death. Arch Med Res. 2006 Jan;37(1):11-8. doi: 10.1016/j.arcmed.2005.05.014. [PubMed:16314180 ]
Lau A, Tymianski M: Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch. 2010 Jul;460(2):525-42. doi: 10.1007/s00424-010-0809-1. Epub 2010 Mar 14. [PubMed:20229265 ]

Only showing the first 10 proteins. There are 119 proteins in total.

Show All

Enzymes

Enzyme Details

1. Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Gene Name:: ALDH4A1
Uniprot ID:: P30038
Molecular weight:: 55117.24

Enzyme Details

2. Glutathione reductase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Maintains high levels of reduced glutathione in the cytosol.
Gene Name:: GSR
Uniprot ID:: P00390
Molecular weight:: 56256.565

Enzyme Details

3. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

General function:: Involved in metabolic process
Specific function:: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Gene Name:: GFPT2
Uniprot ID:: O94808
Molecular weight:: 76929.885

Enzyme Details

4. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

General function:: Involved in metabolic process
Specific function:: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Gene Name:: GFPT1
Uniprot ID:: Q06210
Molecular weight:: 78805.81

Enzyme Details

5. 4-aminobutyrate aminotransferase, mitochondrial

General function:: Involved in 4-aminobutyrate transaminase activity
Specific function:: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:: ABAT
Uniprot ID:: P80404
Molecular weight:: 56438.405

Enzyme Details

6. Tyrosine aminotransferase

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Gene Name:: TAT
Uniprot ID:: P17735
Molecular weight:: 50398.895

Enzyme Details

7. Aspartate aminotransferase, cytoplasmic

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Plays a key role in amino acid metabolism (By similarity).
Gene Name:: GOT1
Uniprot ID:: P17174
Molecular weight:: 46247.14

Enzyme Details

8. Aspartate aminotransferase, mitochondrial

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:: GOT2
Uniprot ID:: P00505
Molecular weight:: 47517.285

Enzyme Details

9. Branched-chain-amino-acid aminotransferase, cytosolic

General function:: Involved in catalytic activity
Specific function:: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Gene Name:: BCAT1
Uniprot ID:: P54687
Molecular weight:: 38644.77

Enzyme Details

10. Amidophosphoribosyltransferase

General function:: Involved in amidophosphoribosyltransferase activity
Specific function:: Not Available
Gene Name:: PPAT
Uniprot ID:: Q06203
Molecular weight:: 57398.52

Transporters

Enzyme Details

1. Monocarboxylate transporter 1

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A1
Uniprot ID:: P53985
Molecular weight:: 53957.7

Enzyme Details

2. Glutamate [NMDA] receptor subunit zeta-1

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors
Gene Name:: GRIN1
Uniprot ID:: Q05586
Molecular weight:: 105371.9

Enzyme Details

3. Glutamate [NMDA] receptor subunit 3B

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:: GRIN3B
Uniprot ID:: O60391
Molecular weight:: 112991.0

Enzyme Details

4. Glutamate [NMDA] receptor subunit epsilon-1

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits
Gene Name:: GRIN2A
Uniprot ID:: Q12879
Molecular weight:: 165281.2

Enzyme Details

5. Glutamate [NMDA] receptor subunit epsilon-3

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:: GRIN2C
Uniprot ID:: Q14957
Molecular weight:: 134531.1

Enzyme Details

6. Glutamate [NMDA] receptor subunit epsilon-2

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:: GRIN2B
Uniprot ID:: Q13224
Molecular weight:: 166365.9

Enzyme Details

7. Glutamate [NMDA] receptor subunit epsilon-4

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:: GRIN2D
Uniprot ID:: O15399
Molecular weight:: 143750.7

Enzyme Details

8. Glutamate receptor, ionotropic kainate 1

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus
Gene Name:: GRIK1
Uniprot ID:: P39086
Molecular weight:: 103979.7

Enzyme Details

9. Glutamate receptor, ionotropic kainate 2

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2
Gene Name:: GRIK2
Uniprot ID:: Q13002
Molecular weight:: 102582.5

Enzyme Details

10. Glutamate receptor, ionotropic kainate 3

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA
Gene Name:: GRIK3
Uniprot ID:: Q13003
Molecular weight:: 104036.1

Only showing the first 10 proteins. There are 119 proteins in total.

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Showing Compound Card for L-Glutamic acid (CDB000130)

Structure for CDB000130 (L-Glutamic acid)

Enzymes

Transporters