| Identification |
|---|
| HMDB Protein ID
| CDBP02240 |
| Secondary Accession Numbers
| Not Available |
| Name
| Excitatory amino acid transporter 3 |
| Description
| Not Available |
| Synonyms
|
- Excitatory amino-acid carrier 1
- Neuronal and epithelial glutamate transporter
- Sodium-dependent glutamate/aspartate transporter 3
- Solute carrier family 1 member 1
|
| Gene Name
| SLC1A1 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in sodium:dicarboxylate symporter activity |
| Specific Function
| Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| sodium:dicarboxylate symporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| transporter activity |
| organic acid transmembrane transporter activity |
| carboxylic acid transmembrane transporter activity |
| dicarboxylic acid transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| organic acid transport |
| carboxylic acid transport |
| dicarboxylic acid transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG |
|---|
| Kidney Function |    | Not Available | | Glucose Transporter Defect (SGLT2) |    | Not Available | | Hartnup Disorder |    | Not Available | | Iminoglycinuria |    | Not Available | | Lysinuric Protein Intolerance |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p24 |
| SNPs
| SLC1A1 |
| Gene Sequence
|
>1575 bp
ATGGGGAAACCGGCGAGGAAAGGATGCGAGTGGAAGCGCTTCCTGAAGAATAACTGGGTG
TTGCTGTCCACCGTGGCCGCGGTGGTGCTAGGCATTACCACAGGAGTCTTGGTTCGAGAA
CACAGCAACCTCTCAACTCTAGAGAAATTCTACTTTGCTTTTCCTGGAGAAATTCTAATG
CGGATGCTGAAACTCATCATTTTGCCATTAATTATATCCAGCATGATTACAGGTGTTGCT
GCACTGGATTCCAACGTATCCGGAAAAATTGGTCTGCGCGCTGTCGTGTATTATTTCTGT
ACCACTCTCATTGCTGTTATTCTAGGTATTGTGCTGGTGGTGAGCATCAAGCCTGGTGTC
ACCCAGAAAGTGGGTGAAATTGCGAGGACAGGCAGCACCCCTGAAGTCAGTACAGTGGAT
GCCATGTTAGATCTCATCAGGAATATGTTCCCTGAGAATCTTGTCCAGGCCTGTTTTCAG
CAGTACAAAACTAAGCGTGAAGAAGTGAAGCCTCCCAGCGATCCAGAGATGAACATGACA
GAAGAGTCCTTCACAGCTGTCATGACAACTGCAATTTCCAAGAACAAAACAAAGGAATAC
AAAATTGTTGGCATGTATTCAGATGGCATAAACGTCCTGGGCTTGATTGTCTTTTGCCTT
GTCTTTGGACTTGTCATTGGAAAAATGGGAGAAAAGGGACAAATTCTGGTGGATTTCTTC
AATGCTTTGAGTGATGCAACCATGAAAATCGTTCAGATCATCATGTGTTATATGCCACTA
GGTATTTTGTTCCTGATTGCTGGGAAGATCATAGAAGTTGAAGACTGGGAAATATTCCGC
AAGCTGGGCCTTTACATGGCCACAGTCCTGACTGGGCTTGCAATCCACTCCATTGTAATT
CTCCCGCTGATATATTTCATAGTCGTACGAAAGAACCCTTTCCGATTTGCCATGGGAATG
GCCCAGGCTCTCCTGACAGCTCTCATGATCTCTTCCAGTTCAGCAACACTGCCTGTCACC
TTCCGCTGTGCTGAAGAAAATAACCAGGTGGACAAGAGGATCACTCGATTCGTGTTACCC
GTTGGTGCAACAATCAACATGGATGGGACTGCGCTCTATGAAGCAGTGGCAGCGGTGTTT
ATTGCACAGTTGAATGACCTGGACTTGGGCATTGGGCAGATCATCACCATCAGTATCACG
GCCACATCTGCCAGCATCGGAGCTGCTGGCGTGCCCCAGGCTGGCCTGGTGACCATGGTG
ATTGTGCTGAGTGCCGTGGGCCTGCCCGCCGAGGATGTCACCCTGATCATTGCTGTCGAC
TGGCTCCTGGACCGGTTCAGGACCATGGTCAACGTCCTTGGTGATGCTTTTGGGACGGGC
ATTGTGGAAAAGCTCTCCAAGAAGGAGCTGGAGCAGATGGATGTTTCATCTGAAGTCAAC
ATTGTGAATCCCTTTGCCTTGGAATCCACAATCCTTGACAACGAAGACTCAGACACCAAG
AAGTCTTATGTCAATGGAGGCTTTGCAGTAGACAAGTCTGACACCATCTCATTCACCCAG
ACCTCACAGTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 524 |
| Molecular Weight
| 57099.8 |
| Theoretical pI
| 5.36 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["19-38", "62-82", "94-114", "210-229", "254-273", "290-309", "316-335", "362-381", "392-411", "420-439"]
|
| Protein Sequence
|
>Excitatory amino acid transporter 3
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILM
RMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMT
EESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF
NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
|
| External Links |
|---|
| GenBank ID Protein
| 18157236 |
| UniProtKB/Swiss-Prot ID
| P43005 |
| UniProtKB/Swiss-Prot Entry Name
| EAA3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB008536 |
| GeneCard ID
| SLC1A1 |
| GenAtlas ID
| SLC1A1 |
| HGNC ID
| HGNC:10939 |
| References |
|---|
| General References
| Not Available |