| Identification |
|---|
| HMDB Protein ID
| CDBP02495 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mitochondrial glutamate carrier 1 |
| Description
| Not Available |
| Synonyms
|
- GC-1
- Glutamate/H(+) symporter 1
- Solute carrier family 25 member 22
|
| Gene Name
| SLC25A22 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).
|
| GO Classification
|
| Cellular Component |
| nucleus |
| integral to membrane |
| mitochondrial inner membrane |
| Component |
| organelle membrane |
| organelle inner membrane |
| mitochondrial inner membrane |
| membrane |
| cell part |
| Function |
| binding |
| transporter activity |
| Molecular Function |
| symporter activity |
| L-glutamate transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Mitochondrion inner membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glucose-Alanine Cycle |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p15.5 |
| SNPs
| SLC25A22 |
| Gene Sequence
|
>972 bp
ATGGCTGATAAGCAGATCAGCCTGCCAGCCAAGCTCATCAATGGCGGCATCGCCGGGCTG
ATCGGTGTCACCTGCGTGTTTCCCATCGACCTGGCCAAGACCAGGCTGCAGAACCAGCAG
AACGGCCAGCGCGTGTACACGAGCATGTCCGACTGCCTCATCAAGACCGTCCGCTCCGAG
GGCTACTTCGGCATGTACCGGGGAGCTGCTGTGAACTTGACCCTCGTCACCCCCGAGAAG
GCCATCAAGCTGGCAGCCAACGACTTCTTCCGACATCAGCTCTCTAAGGACGGGCAGAAG
CTGACCCTGCTTAAAGAGATGCTGGCGGGCTGTGGGGCTGGCACCTGCCAGGTGATCGTG
ACCACGCCCATGGAGATGCTGAAGATCCAGCTGCAGGATGCAGGGCGCATTGCCGCCCAG
AGGAAGATCCTGGCTGCCCAGGGCCAGCTCTCGGCCCAGGGGGGTGCCCAGCCCTCAGTG
GAGGCTCCAGCTGCCCCTCGGCCCACGGCCACCCAGCTGACCCGCGACCTGCTGCGGAGC
CGTGGCATTGCCGGTCTCTACAAGGGACTCGGGGCCACGCTGCTCAGGGATGTCCCCTTC
TCTGTGGTGTACTTCCCGCTCTTTGCCAACCTGAACCAGCTGGGCCGCCCGGCGTCCGAG
GAGAAGTCGCCTTTCTACGTGTCCTTCCTGGCCGGCTGTGTGGCTGGGAGTGCCGCCGCT
GTGGCCGTCAACCCCTGTGATGTGGTGAAGACGCGGCTCCAGTCACTTCAGCGAGGCGTC
AACGAGGACACCTACTCTGGGATCCTGGACTGTGCCAGGAAGATCCTGCGGCACGAGGGC
CCCTCGGCCTTCCTGAAGGGCGCCTACTGCCGCGCGCTGGTCATCGCGCCCCTTTTCGGC
ATCGCACAGGTGGTCTACTTCCTGGGCATCGCGGAGTCCCTGCTGGGGCTGCTGCAGGAC
CCCCAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 323 |
| Molecular Weight
| 34469.85 |
| Theoretical pI
| 9.295 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mitochondrial glutamate carrier 1
MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSE
GYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV
TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS
RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA
VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG
IAQVVYFLGIAESLLGLLQDPQA
|
| External Links |
|---|
| GenBank ID Protein
| 21322705 |
| UniProtKB/Swiss-Prot ID
| Q9H936 |
| UniProtKB/Swiss-Prot Entry Name
| GHC1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ428202 |
| GeneCard ID
| SLC25A22 |
| GenAtlas ID
| SLC25A22 |
| HGNC ID
| HGNC:19954 |
| References |
|---|
| General References
| Not Available |