| Identification |
|---|
| HMDB Protein ID
| CDBP04677 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Glutaminyl-tRNA synthase-like protein 1
- Glu-AdT subunit A
|
| Gene Name
| QRSL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
| Specific Function
| Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
|
| GO Classification
|
| Biological Process |
| glutaminyl-tRNAGln biosynthesis via transamidation |
| mitochondrial translation |
| Cellular Component |
| mitochondrion |
| glutamyl-tRNA(Gln) amidotransferase complex |
| Function |
| catalytic activity |
| ligase activity |
| carbon-nitrogen ligase activity, with glutamine as amido-n-donor |
| ligase activity, forming carbon-nitrogen bonds |
| Molecular Function |
| ATP binding |
| glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| Process |
| macromolecule biosynthetic process |
| cellular macromolecule biosynthetic process |
| translation |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q21 |
| SNPs
| QRSL1 |
| Gene Sequence
|
>1587 bp
ATGCTGGGCCGGAGCCTCCGAGAAGTTTCTGCGGCACTGAAACAAGGCCAAATTACACCA
ACAGAGCTCTGTCAAAAATGTCTCTCTCTTATCAAGAAGACCAAGTTTCTAAATGCCTAC
ATTACTGTGTCAGAAGAGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGATATAAG
AATGGACAGTCACTTGGGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGC
ACTTCTGGCATTGAGACAACATGTGCATCAAATATGCTGAAAGGTTATATACCACCTTAT
AATGCTACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCTACTAATGGGAAAAACAAAT
TTAGATGAGTTTGCTATGGGATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAAC
CCCTGGAGTTATTCAAAACAATATAGAGAAAAGAGGAAGCAGAATCCCCACAGCGAGAAT
GAAGATTCAGACTGGCTGATAACTGGAGGAAGCTCAGGTGGGAGTGCAGCTGCTGTATCG
GCGTTCACATGCTACGCGGCTTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCT
GCCCACTGTGGGCTTGTTGGTTTCAAACCAAGCTATGGCTTAGTTTCCCGTCATGGTCTC
ATTCCCCTGGTGAATTCGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCA
GCAATTGTGTTGGGTGCACTGGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAA
CCTATTAATAAACCATTCATGCTTCCCAGTTTGGCAGATGTGAGCAAACTATGTATAGGA
ATTCCAAAGGAATATCTTGTACCGGAATTATCAAGTGAAGTACAGTCTCTTTGGTCCAAA
GCTGCTGACCTCTTTGAGTCTGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACC
AGTTATTCAATTGTCTGCTACCATGTATTGTGCACATCAGAAGTGGCATCGAATATGGCA
AGATTTGATGGGCTACAATATGGTCACAGATGTGACATTGATGTGTCCACTGAAGCCATG
TATGCTGCAACCAGACGAGAAGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTCAGGA
AACTTTTTCTTATTAAAAGAAAACTATGAAAATTATTTTGTCAAAGCACAGAAAGTGAGA
CGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGGAGTAGATGTCTTGCTAACT
CCCACCACCTTGAGTGAGGCAGTACCATACTTGGAGTTCATCAAAGAGGACAACAGAACC
CGAAGTGCCCAGGATGATATTTTTACACAAGCTGTAAATATGGCAGGATTGCCAGCAGTG
AGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGT
GCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTT
CCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAATGAAAAG
TTAGCCTCTGTCTCTCTAAAACAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 528 |
| Molecular Weight
| 57459.915 |
| Theoretical pI
| 5.68 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutamyl-tRNA(Gln) amidotransferase subunit A homolog
MLGRSLREVSAALKQGQITPTELCQKCLSLIKKTKFLNAYITVSEEVALKQAEESEKRYK
NGQSLGDLDGIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTN
LDEFAMGSGSTDGVFGPVKNPWSYSKQYREKRKQNPHSENEDSDWLITGGSSGGSAAAVS
AFTCYAALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDA
AIVLGALAGPDPRDSTTVHEPINKPFMLPSLADVSKLCIGIPKEYLVPELSSEVQSLWSK
AADLFESEGAKVIEVSLPHTSYSIVCYHVLCTSEVASNMARFDGLQYGHRCDIDVSTEAM
YAATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFVNAFNSGVDVLLT
PTTLSEAVPYLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQFIGR
AFCDQQLLTVAKWFEKQVQFPVIQLQELMDDCSAVLENEKLASVSLKQ
|
| External Links |
|---|
| GenBank ID Protein
| 7023375 |
| UniProtKB/Swiss-Prot ID
| Q9H0R6 |
| UniProtKB/Swiss-Prot Entry Name
| QRSL1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK001851 |
| GeneCard ID
| QRSL1 |
| GenAtlas ID
| QRSL1 |
| HGNC ID
| HGNC:21020 |
| References |
|---|
| General References
| Not Available |