Identification
HMDB Protein ID CDBP04677
Secondary Accession Numbers Not Available
Name Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Description Not Available
Synonyms
  1. Glutaminyl-tRNA synthase-like protein 1
  2. Glu-AdT subunit A
Gene Name QRSL1
Protein Type Enzyme
Biological Properties
General Function Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Specific Function Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
GO Classification
Biological Process
glutaminyl-tRNAGln biosynthesis via transamidation
mitochondrial translation
Cellular Component
mitochondrion
glutamyl-tRNA(Gln) amidotransferase complex
Function
catalytic activity
ligase activity
carbon-nitrogen ligase activity, with glutamine as amido-n-donor
ligase activity, forming carbon-nitrogen bonds
Molecular Function
ATP binding
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
Process
macromolecule biosynthetic process
cellular macromolecule biosynthetic process
translation
metabolic process
biosynthetic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 6
Locus 6q21
SNPs QRSL1
Gene Sequence
>1587 bp
ATGCTGGGCCGGAGCCTCCGAGAAGTTTCTGCGGCACTGAAACAAGGCCAAATTACACCA
ACAGAGCTCTGTCAAAAATGTCTCTCTCTTATCAAGAAGACCAAGTTTCTAAATGCCTAC
ATTACTGTGTCAGAAGAGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGATATAAG
AATGGACAGTCACTTGGGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGC
ACTTCTGGCATTGAGACAACATGTGCATCAAATATGCTGAAAGGTTATATACCACCTTAT
AATGCTACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCTACTAATGGGAAAAACAAAT
TTAGATGAGTTTGCTATGGGATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAAC
CCCTGGAGTTATTCAAAACAATATAGAGAAAAGAGGAAGCAGAATCCCCACAGCGAGAAT
GAAGATTCAGACTGGCTGATAACTGGAGGAAGCTCAGGTGGGAGTGCAGCTGCTGTATCG
GCGTTCACATGCTACGCGGCTTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCT
GCCCACTGTGGGCTTGTTGGTTTCAAACCAAGCTATGGCTTAGTTTCCCGTCATGGTCTC
ATTCCCCTGGTGAATTCGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCA
GCAATTGTGTTGGGTGCACTGGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAA
CCTATTAATAAACCATTCATGCTTCCCAGTTTGGCAGATGTGAGCAAACTATGTATAGGA
ATTCCAAAGGAATATCTTGTACCGGAATTATCAAGTGAAGTACAGTCTCTTTGGTCCAAA
GCTGCTGACCTCTTTGAGTCTGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACC
AGTTATTCAATTGTCTGCTACCATGTATTGTGCACATCAGAAGTGGCATCGAATATGGCA
AGATTTGATGGGCTACAATATGGTCACAGATGTGACATTGATGTGTCCACTGAAGCCATG
TATGCTGCAACCAGACGAGAAGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTCAGGA
AACTTTTTCTTATTAAAAGAAAACTATGAAAATTATTTTGTCAAAGCACAGAAAGTGAGA
CGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGGAGTAGATGTCTTGCTAACT
CCCACCACCTTGAGTGAGGCAGTACCATACTTGGAGTTCATCAAAGAGGACAACAGAACC
CGAAGTGCCCAGGATGATATTTTTACACAAGCTGTAAATATGGCAGGATTGCCAGCAGTG
AGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGT
GCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTT
CCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAATGAAAAG
TTAGCCTCTGTCTCTCTAAAACAGTAA
Protein Properties
Number of Residues 528
Molecular Weight 57459.915
Theoretical pI 5.68
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Glutamyl-tRNA(Gln) amidotransferase subunit A homolog
MLGRSLREVSAALKQGQITPTELCQKCLSLIKKTKFLNAYITVSEEVALKQAEESEKRYK
NGQSLGDLDGIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTN
LDEFAMGSGSTDGVFGPVKNPWSYSKQYREKRKQNPHSENEDSDWLITGGSSGGSAAAVS
AFTCYAALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDA
AIVLGALAGPDPRDSTTVHEPINKPFMLPSLADVSKLCIGIPKEYLVPELSSEVQSLWSK
AADLFESEGAKVIEVSLPHTSYSIVCYHVLCTSEVASNMARFDGLQYGHRCDIDVSTEAM
YAATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFVNAFNSGVDVLLT
PTTLSEAVPYLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQFIGR
AFCDQQLLTVAKWFEKQVQFPVIQLQELMDDCSAVLENEKLASVSLKQ
GenBank ID Protein 7023375
UniProtKB/Swiss-Prot ID Q9H0R6
UniProtKB/Swiss-Prot Entry Name QRSL1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK001851
GeneCard ID QRSL1
GenAtlas ID QRSL1
HGNC ID HGNC:21020
References
General References Not Available