Identification |
HMDB Protein ID
| CDBP00210 |
Secondary Accession Numbers
| Not Available |
Name
| Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
Description
| Not Available |
Synonyms
|
- D-fructose-6-phosphate amidotransferase 1
- GFAT 1
- GFAT1
- Glutamine:fructose 6 phosphate amidotransferase 1
- Hexosephosphate aminotransferase 1
- Glutamine:fructose-6-phosphate amidotransferase 1
|
Gene Name
| GFPT1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in metabolic process |
Specific Function
| Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
|
GO Classification
|
Biological Process |
glutamine metabolic process |
negative regulation of glycogen biosynthetic process |
dolichol-linked oligosaccharide biosynthetic process |
post-translational protein modification |
protein N-linked glycosylation via asparagine |
UDP-N-acetylglucosamine biosynthetic process |
cellular response to insulin stimulus |
response to sucrose stimulus |
glucosamine biosynthetic process |
carbohydrate biosynthetic process |
fructose 6-phosphate metabolic process |
energy reserve metabolic process |
protein homotetramerization |
activation of signaling protein activity involved in unfolded protein response |
Cellular Component |
cytosol |
Component |
cell part |
intracellular part |
cytoplasm |
intracellular |
cell |
Function |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring nitrogenous groups |
transaminase activity |
glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
carbohydrate binding |
sugar binding |
Molecular Function |
amino acid binding |
carbohydrate binding |
glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
Process |
metabolic process |
primary metabolic process |
carbohydrate metabolic process |
physiological process |
metabolism |
macromolecule metabolism |
carbohydrate biosynthesis |
carbohydrate biosynthetic process |
macromolecule biosynthesis |
carbohydrate metabolism |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | UDP-N-acetyl-alpha-D-glucosamine biosynthesis | Not Available | Not Available | Alanine, aspartate and glutamate metabolism | Not Available | | Amino sugar and nucleotide sugar metabolism | Not Available | | Amino Sugar Metabolism | | | Sialuria or French Type Sialuria | | Not Available |
|
Gene Properties |
Chromosome Location
| 2 |
Locus
| 2p13 |
SNPs
| GFPT1 |
Gene Sequence
|
>2046 bp
ATGTGTGGTATATTTGCTTACTTAAACTACCATGTTCCTCGAACGAGACGAGAAATCCTG
GAGACCCTAATCAAAGGCCTTCAGAGACTGGAGTACAGAGGATATGATTCTGCTGGTGTG
GGATTTGATGGAGGCAATGATAAAGATTGGGAAGCCAATGCCTGCAAAATCCAGCTTATT
AAGAAGAAAGGAAAAGTTAAGGCACTGGATGAAGAAGTTCACAAGCAACAAGATATGGAT
TTGGATATAGAATTTGATGTACACCTTGGAATAGCTCATACCCGTTGGGCAACACATGGA
GAACCCAGTCCTGTCAATAGCCACCCCCAGCGCTCTGATAAAAATAATGAATTTATCGTT
ATTCACAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTTTTTGGAAAGCAAAGGC
TATGACTTCGAATCTGAAACAGACACAGAGACAATTGCCAAGCTCGTTAAGTATATGTAT
GACAATCGGGAAAGTCAAGATACCAGCTTTACTACCTTGGTGGAGAGAGTTATCCAACAA
TTGGAAGGTGCTTTTGCACTTGTGTTTAAAAGTGTTCATTTTCCCGGGCAAGCAGTTGGC
ACAAGGCGAGGTAGCCCTCTGTTGATTGGTGTACGGAGTGAACATAAACTTTCTACTGAT
CACATTCCTATACTCTACAGAACAGGCAAAGACAAGAAAGGAAGCTGCAATCTCTCTCGT
GTGGACAGCACAACCTGCCTTTTCCCGGTGGAAGAAAAAGCAGTGGAGTATTACTTTGCT
TCTGATGCAAGTGCTGTCATAGAACACACCAATCGCGTCATCTTTCTGGAAGATGATGAT
GTTGCAGCAGTAGTGGATGGACGTCTTTCTATCCATCGAATTAAACGAACTGCAGGAGAT
CACCCCGGACGAGCTGTGCAAACACTCCAGATGGAACTCCAGCAGATCATGAAGGGCAAC
TTCAGTTCATTTATGCAGAAGGAAATATTTGAGCAGCCAGAGTCTGTCGTGAACACAATG
AGAGGAAGAGTCAACTTTGATGACTATACTGTGAATTTGGGTGGTTTGAAGGATCACATA
AAGGAGATCCAGAGATGCCGGCGTTTGATTCTTATTGCTTGTGGAACAAGTTACCATGCT
GGTGTAGCAACACGTCAAGTTCTTGAGGAGCTGACTGAGTTGCCTGTGATGGTGGAACTA
GCAAGTGACTTCCTGGACAGAAACACACCAGTCTTTCGAGATGATGTTTGCTTTTTCCTT
AGTCAATCAGGTGAGACAGCAGATACTTTGATGGGTCTTCGTTACTGTAAGGAGAGAGGA
GCTTTAACTGTGGGGATCACAAACACAGTTGGCAGTTCCATATCACGGGAGACAGATTGT
GGAGTTCATATTAATGCTGGTCCTGAGATTGGTGTGGCCAGTACAAAGGCTTATACCAGC
CAGTTTGTATCCCTTGTGATGTTTGCCCTTATGATGTGTGATGATCGGATCTCCATGCAA
GAAAGACGCAAAGAGATCATGCTTGGATTGAAACGGCTGCCTGATTTGATTAAGGAAGTA
CTGAGCATGGATGACGAAATTCAGAAACTAGCAACAGAACTTTATCATCAGAAGTCAGTT
CTGATAATGGGACGAGGCTATCATTATGCTACTTGTCTTGAAGGGGCACTGAAAATCAAA
GAAATTACTTATATGCACTCTGAAGGCATCCTTGCTGGTGAATTGAAACATGGCCCTCTG
GCTTTGGTGGATAAATTGATGCCTGTGATCATGATCATCATGAGAGATCACACTTATGCC
AAGTGTCAGAATGCTCTTCAGCAAGTGGTTGCTCGGCAGGGGCGGCCTGTGGTAATTTGT
GATAAGGAGGATACTGAGACCATTAAGAACACAAAAAGAACGATCAAGGTGCCCCACTCA
GTGGACTGCTTGCAGGGCATTCTCAGCGTGATCCCTTTACAGTTGCTGGCTTTCCACCTT
GCTGTGCTGAGAGGCTATGATGTTGATTTCCCACGGAATCTTGCCAAATCTGTGACTGTA
GAGTGA
|
Protein Properties |
Number of Residues
| 699 |
Molecular Weight
| 78805.81 |
Theoretical pI
| 7.107 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
|
External Links |
GenBank ID Protein
| 205277386 |
UniProtKB/Swiss-Prot ID
| Q06210 |
UniProtKB/Swiss-Prot Entry Name
| GFPT1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AC114772 |
GeneCard ID
| GFPT1 |
GenAtlas ID
| GFPT1 |
HGNC ID
| HGNC:4241 |
References |
General References
| Not Available |