Cannabis Compound Database: Showing Compound Card for Cytidine triphosphate (CDB005198)

Jump To Section:

Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (64) Show 124 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:19:10 UTC

Updated at

2020-11-18 16:39:30 UTC

CannabisDB ID

CDB005198

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Cytidine triphosphate

Description

Cytidine triphosphate, also known as 5'-CTP or H4CTP, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. CTP, much like ATP, consists of a ribose sugar, and three phosphate groups. Cytidine triphosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). CTP is a high-energy molecule similar to ATP, but its role as an energy coupler is limited to a much smaller subset of metabolic reactions. Cytidine triphosphate exists in all living species, ranging from bacteria to humans. Outside of the human body, Cytidine triphosphate has been detected, but not quantified in, several different foods, such as mung beans, wild rices, jostaberries, radish, and common mushrooms. This could make cytidine triphosphate a potential biomarker for the consumption of these foods. Cytidine triphosphate is a pyrimidine nucleoside triphosphate. CTP acts as an inhibitor of the enzyme aspartate carbamoyltransferase, which is used in pyrimidine biosynthesis. CTP is a substrate in the synthesis of RNA. The major difference between the two molecules is the base used, which in CTP is cytosine. CTP is a coenzyme in metabolic reactions like the synthesis of glycerophospholipids and glycosylation of proteins. Cytidine triphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
5'-CTP	ChEBI
Cytidine 5'-triphosphate	ChEBI
CYTIDINE-5'-triphosphATE	ChEBI
H4CTP	ChEBI
Cytidine 5'-triphosphoric acid	Generator
CYTIDINE-5'-triphosphoric acid	Generator
Cytidine triphosphoric acid	Generator
5'-(Tetrahydrogen triphosphate) cytidine	HMDB
CTP	HMDB
Cytidine 3'-triphosphate	HMDB
Cytidine 5'-(tetrahydrogen triphosphate)	HMDB
Cytidine 5-prime-triphosphate	HMDB
Cytidine mono	HMDB
Cytidine mono(tetrahydrogen triphosphate) (ester)	HMDB
Deoxycytosine triphosphate	HMDB
Triphosphate, cytidine	HMDB
CRPPP	HMDB
Magnesium CTP	HMDB
MG CTP	HMDB

Chemical Formula

C₉H₁₆N₃O₁₄P₃

Average Molecular Weight

483.16

Monoisotopic Molecular Weight

482.9845

IUPAC Name

({[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

Traditional Name

CTP

CAS Registry Number

65-47-4

SMILES

NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

InChI Identifier

InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

InChI Key

PCDQPRRSZKQHHS-XVFCMESISA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Pentose phosphates

Alternative Parents

Substituents

Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
Monosaccharide phosphate
Hydroxypyrimidine
Monoalkyl phosphate
Hydropyrimidine
Organic phosphoric acid derivative
Alkyl phosphate
Phosphoric acid ester
Pyrimidine
Heteroaromatic compound
Tetrahydrofuran
1,2-diol
Secondary alcohol
Azacycle
Oxacycle
Organoheterocyclic compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic nitrogen compound
Alcohol
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

cytidine 5'-phosphate (CHEBI:17677 )
pyrimidine ribonucleoside 5'-triphosphate (CHEBI:17677 )
Ribonucleotides (C00063 )
Coenzymes (C00063 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Biological location:

Tissue and substructures:

All tissues

Subcellular:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	215 - 218 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.34	ALOGPS
logP	-4.1	ChemAxon
logS	-1.6	ALOGPS
pKa (Strongest Acidic)	0.94	ChemAxon
pKa (Strongest Basic)	-0.076	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	13	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	268.2 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	87.16 m³·mol⁻¹	ChemAxon
Polarizability	35.87 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Cytidine triphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-002b-8965400000-028238d320c37d90d959	Spectrum
Predicted GC-MS	Cytidine triphosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-03l3-4529211000-fc9c3bce80ab4bd56bec	Spectrum
Predicted GC-MS	Cytidine triphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_1_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_10, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_11, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_12, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_13, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_14, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_15, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_16, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cytidine triphosphate, TMS_2_17, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-00b9-5685900000-b067d3b0af4c194d5224	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0a4i-0309200000-33e695326ec0d28103b4	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-057j-1926700000-417741bbe965170223c0	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 10V, negative	splash10-001i-0201900000-d0f4b76212c986ba5256	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 15V, negative	splash10-053r-0602900000-3b15e1314bb085815ee1	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 17V, negative	splash10-053r-0913800000-a9781bf9478c1556ea6f	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 20V, negative	splash10-0a59-1903500000-ca05dcfb3a7e6249de5f	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 23V, negative	splash10-0a59-1912200000-ed35edf8dd897cfb189f	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 25V, negative	splash10-0a4i-1912100000-02368a767858b532e343	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 27V, negative	splash10-0a4i-1901100000-7e158597e6539f859f18	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 30V, negative	splash10-0a4i-2901000000-e6ffe54064813cca999a	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 33V, negative	splash10-0a4i-2901000000-878ed1a77bece120cab0	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 35V, negative	splash10-0a4i-3900000000-5609836a3262551e3f22	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 40V, negative	splash10-0a6r-4900000000-25ee9e049ac582f88998	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 45V, negative	splash10-0a6r-6900000000-df141b7c324466d11ca1	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 33V, negative	splash10-001i-0109000000-e4e73cfc21a26fa84c94	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 18V, negative	splash10-001i-0100900000-1d8f337531a62dff2aef	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 23V, negative	splash10-053r-0703900000-43af4aa75af7c1b90a19	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 29V, negative	splash10-0a4i-0902200000-9cabc619fb140d01b9d7	2020-07-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-0901100000-c35d289f50f6f03e2607	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03di-2901000000-52ceb0833c1f651ee73e	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-5900000000-b2b882bb438556aea202	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-01q9-0520900000-0e5b8be0fa0c2178439b	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0bwi-9660200000-4db67ca241ce3068a27f	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9200000000-1f093b0fe69d03ecea98	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Pyrimidine Metabolism
Transcription/Translation	Not Available	Not Available
DNA Replication Fork	Not Available	Not Available
Amino Sugar Metabolism
Sialuria or French Type Sialuria		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleoside triphosphate diphosphohydrolase 1	ENTPD1	10q24	P49961	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Ectonucleoside triphosphate diphosphohydrolase 3	ENTPD3	3p21.3	O75355	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase A	NME1	17q21.3	P15531	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
N-acylneuraminate cytidylyltransferase	CMAS	12p12.1	Q8NFW8	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
CTP synthase 1	CTPS1	1p34.1	P17812	details
Choline-phosphate cytidylyltransferase B	PCYT1B	Xp22.11	Q9Y5K3	details
6-phosphofructokinase type C	PFKP	10p15.3-p15.2	Q01813	details
DNA-directed RNA polymerase III subunit RPC4	POLR3D		P05423	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
Ethanolamine-phosphate cytidylyltransferase	PCYT2	17q25.3	Q99447	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC7	POLR3G		O15318	details
Phosphatidate cytidylyltransferase 2	CDS2	20p13	O95674	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
Choline-phosphate cytidylyltransferase A	PCYT1A	3q29	P49585	details
DNA-directed RNA polymerase I subunit RPA49	POLR1E	9p13.2	Q9GZS1	details
6-phosphofructokinase, liver type	PFKL	21q22.3	P17858	details
DNA-directed RNA polymerase III subunit RPC8	POLR3H		Q9Y535	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
6-phosphofructokinase, muscle type	PFKM	12q13.3	P08237	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Phosphatidate cytidylyltransferase 1	CDS1	4q21.23	Q92903	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
Uridine-cytidine kinase 2	UCK2	1q23	Q9BZX2	details
Phosphopantothenate--cysteine ligase	PPCS	1p34.2	Q9HAB8	details
CTP synthase 2	CTPS2	Xp22	Q9NRF8	details
Ectonucleoside triphosphate diphosphohydrolase 8	ENTPD8	9q34.3	Q5MY95	details
Putative nucleoside diphosphate kinase	NME2P1	12q24.31	O60361	details
CCA tRNA nucleotidyltransferase 1, mitochondrial	TRNT1	3p25.1	Q96Q11	details
Dolichol kinase	DOLK	9q34.11	Q9UPQ8	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
DNA-directed RNA polymerases I and III subunit RPAC2	POLR1D	13q12.2	Q9Y2S0	details
DNA-directed RNA polymerase	DKFZp686D10173		Q7Z3R8	details
DNA-directed RNA polymerase III subunit RPC7-like	POLR3GL		Q9BT43	details
POLR1C protein	POLR1C	6p21.1	Q96HT3	details
Nucleoside diphosphate kinase homolog 5	NME5		P56597	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerase I subunit RPA43	TWISTNB	7p21.1	Q3B726	details
DNA-directed RNA polymerases I, II, and III subunit RPABC1	POLR2E	19p13.3	P19388	details
DNA-directed RNA polymerases I, II, and III subunit RPABC2	POLR2F	22q13.1	P61218	details
DNA-directed RNA polymerases I, II, and III subunit RPABC3	POLR2H	3q28	P52434	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerases I and III subunit RPAC1	POLR1C	6p21.1	O15160	details
DNA-directed RNA polymerase II subunit RPB11-a	POLR2J	7q22.1	P52435	details
DNA-directed RNA polymerase II subunit RPB11-b1	POLR2J2	7q22.1	Q9GZM3	details
DNA-directed RNA polymerase II subunit RPB3	POLR2C	16q13-q21	P19387	details
DNA-directed RNA polymerase II subunit RPB4	POLR2D	2q21	O15514	details
DNA-directed RNA polymerase II subunit RPB7	POLR2G	11q13.1	P62487	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details
DNA-directed RNA polymerase III subunit RPC3	POLR3C		Q9BUI4	details
DNA-directed RNA polymerase III subunit RPC5	POLR3E		Q9NVU0	details
DNA-directed RNA polymerase III subunit RPC6	POLR3F		Q9H1D9	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
6-phosphofructokinase type C	PFKP	10p15.3-p15.2	Q01813	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
6-phosphofructokinase, liver type	PFKL	21q22.3	P17858	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
6-phosphofructokinase, muscle type	PFKM	12q13.3	P08237	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
CAD protein	CAD	2p22-p21	P27708	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details

Receptors

Not Available

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
DNA-directed RNA polymerase III subunit RPC4	POLR3D		P05423	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC7	POLR3G		O15318	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA-directed RNA polymerase I subunit RPA49	POLR1E	9p13.2	Q9GZS1	details
DNA-directed RNA polymerase III subunit RPC8	POLR3H		Q9Y535	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
DNA-directed RNA polymerases I and III subunit RPAC2	POLR1D	13q12.2	Q9Y2S0	details
DNA-directed RNA polymerase	DKFZp686D10173		Q7Z3R8	details
DNA-directed RNA polymerase III subunit RPC7-like	POLR3GL		Q9BT43	details
POLR1C protein	POLR1C	6p21.1	Q96HT3	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerase I subunit RPA43	TWISTNB	7p21.1	Q3B726	details
DNA-directed RNA polymerases I, II, and III subunit RPABC1	POLR2E	19p13.3	P19388	details
DNA-directed RNA polymerases I, II, and III subunit RPABC2	POLR2F	22q13.1	P61218	details
DNA-directed RNA polymerases I, II, and III subunit RPABC3	POLR2H	3q28	P52434	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerases I and III subunit RPAC1	POLR1C	6p21.1	O15160	details
DNA-directed RNA polymerase II subunit RPB11-a	POLR2J	7q22.1	P52435	details
DNA-directed RNA polymerase II subunit RPB11-b1	POLR2J2	7q22.1	Q9GZM3	details
DNA-directed RNA polymerase II subunit RPB3	POLR2C	16q13-q21	P19387	details
DNA-directed RNA polymerase II subunit RPB4	POLR2D	2q21	O15514	details
DNA-directed RNA polymerase II subunit RPB7	POLR2G	11q13.1	P62487	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details
DNA-directed RNA polymerase III subunit RPC3	POLR3C		Q9BUI4	details
DNA-directed RNA polymerase III subunit RPC5	POLR3E		Q9NVU0	details
DNA-directed RNA polymerase III subunit RPC6	POLR3F		Q9H1D9	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000082

DrugBank ID

DB02431

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Cytidine triphosphate

METLIN ID

5136

PubChem Compound

6176

PDB ID

Not Available

ChEBI ID

17677

References

General References

Not Available

Only showing the first 10 proteins. There are 124 proteins in total.

Show All

Enzymes

Enzyme Details

1. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Enzyme Details

2. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Enzyme Details

3. Ectonucleoside triphosphate diphosphohydrolase 3

General function:: Involved in hydrolase activity
Specific function:: Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:: ENTPD3
Uniprot ID:: O75355
Molecular weight:: 59104.76

Enzyme Details

4. Nucleoside diphosphate kinase, mitochondrial

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:: NME4
Uniprot ID:: O00746
Molecular weight:: 20658.45

Enzyme Details

5. Nucleoside diphosphate kinase A

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:: NME1
Uniprot ID:: P15531
Molecular weight:: 17148.635

Enzyme Details

6. Nucleoside diphosphate kinase 7

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:: NME7
Uniprot ID:: Q9Y5B8
Molecular weight:: 42491.365

Enzyme Details

7. Nucleoside diphosphate kinase B

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:: NME2
Uniprot ID:: P22392
Molecular weight:: 30136.92

Enzyme Details

8. Nucleoside diphosphate kinase 3

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Gene Name:: NME3
Uniprot ID:: Q13232
Molecular weight:: 19014.85

Enzyme Details

9. Nucleoside diphosphate kinase 6

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Gene Name:: NME6
Uniprot ID:: O75414
Molecular weight:: 22002.965

Enzyme Details

10. N-acylneuraminate cytidylyltransferase

General function:: Involved in lipopolysaccharide biosynthetic process
Specific function:: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
Gene Name:: CMAS
Uniprot ID:: Q8NFW8
Molecular weight:: 48378.835

Only showing the first 10 proteins. There are 124 proteins in total.

Show All

Showing Compound Card for Cytidine triphosphate (CDB005198)

Structure for CDB005198 (Cytidine triphosphate)

Enzymes