Cannabis Compound Database: Showing Compound Card for Sphinganine (CDB004832)

Jump To Section:

Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (47)transporters (7) Show 65 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:41:22 UTC

Updated at

2020-12-07 19:11:03 UTC

CannabisDB ID

CDB004832

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Sphinganine

Description

Sphinganine, also known as D18:0 or safingol, belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Thus, sphinganine is considered to be a sphingoid base lipid molecule. Sphinganine is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Sphinganine exists in all living species, ranging from bacteria to humans. Within humans, sphinganine participates in a number of enzymatic reactions. In particular, sphinganine can be converted into 3-dehydrosphinganine; which is mediated by the enzyme 3-ketodihydrosphingosine reductase. In addition, sphinganine can be converted into sphinganine 1-phosphate; which is catalyzed by the enzyme sphingosine kinase 2. In humans, sphinganine is involved in the metabolic disorder called the fabry disease pathway. Outside of the human body, Sphinganine has been detected, but not quantified in, several different foods, such as beech nuts, docks, citrus, watercress, and brazil nuts. This could make sphinganine a potential biomarker for the consumption of these foods. A Sphinganine having (2S,3R)-configuration. Sphinganine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S,3R)-2-Amino-1,3-octadecanediol	ChEBI
(2S,3R)-2-Aminooctadecane-1,3-diol	ChEBI
(R-(R,s))-2-aminooctadecane-1,3-diol	ChEBI
2-Amino-1,3-dihydroxyoctadecane	ChEBI
C18-Dihydrosphingosine	ChEBI
C18-Sphinganine	ChEBI
D-Erythro-1,3-dihydroxy-2-aminooctadecane	ChEBI
D-Erythro-2-amino-1,3-octadecanediol	ChEBI
D-Erythro-C18-dihydrosphingosine	ChEBI
D18:0	ChEBI
Dihydrosphingosine	ChEBI
Octadecasphinganine	ChEBI
Safingol	ChEBI
Erythro-D-sphinganine	HMDB
2-Aminooctadecane-1,3-diol	HMDB
Threo-dihydrosphingosine	HMDB
2-Amino-D-erythro-1,3-octadecanediol	HMDB
C18-Dihydro-sphingosine	HMDB
D-Erythro-sphinganine	HMDB
Dihydro-C18-sphingosine	HMDB
Erythro-sphinganine	HMDB
[R-(R,s)]-2-amino-1,3-octadecanediol	HMDB
(2S,3R)-Sphinganine	HMDB
D-Erythro-dihydrosphingosine	HMDB
SP(D18:0)	HMDB
Sphinganine	HMDB

Chemical Formula

C₁₈H₃₉NO₂

Average Molecular Weight

301.51

Monoisotopic Molecular Weight

301.2981

IUPAC Name

(2S,3R)-2-aminooctadecane-1,3-diol

Traditional Name

sphinganine

CAS Registry Number

764-22-7

SMILES

CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO

InChI Identifier

InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1

InChI Key

OTKJDMGTUTTYMP-ZWKOTPCHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.

Kingdom

Organic compounds

Super Class

Organic nitrogen compounds

Class

Organonitrogen compounds

Sub Class

Amines

Direct Parent

1,2-aminoalcohols

Alternative Parents

Substituents

Secondary alcohol
1,2-aminoalcohol
Organic oxygen compound
Organopnictogen compound
Hydrocarbon derivative
Primary amine
Primary alcohol
Organooxygen compound
Primary aliphatic amine
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

2-aminooctadecane-1,3-diol (CHEBI:16566 )
Sphinganines (C00836 )
Sphinganines (LMSP01020001 )

Ontology

Physiological effect

Health effect:

Health condition:

Pregnancy

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.2	ALOGPS
logP	4.77	ChemAxon
logS	-4.8	ALOGPS
pKa (Strongest Acidic)	14.42	ChemAxon
pKa (Strongest Basic)	9.29	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	66.48 Å²	ChemAxon
Rotatable Bond Count	16	ChemAxon
Refractivity	90.93 m³·mol⁻¹	ChemAxon
Polarizability	40.68 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Sphinganine, 3 TMS, GC-MS Spectrum	splash10-0udi-3980100000-87c0074f611dec416856	Spectrum
GC-MS	Sphinganine, 3 TMS, GC-MS Spectrum	splash10-0udi-1690000000-8fed2f980c631302b97b	Spectrum
GC-MS	Sphinganine, non-derivatized, GC-MS Spectrum	splash10-0udi-3980100000-87c0074f611dec416856	Spectrum
GC-MS	Sphinganine, non-derivatized, GC-MS Spectrum	splash10-0udi-1690000000-8fed2f980c631302b97b	Spectrum
Predicted GC-MS	Sphinganine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-03di-9120000000-0cfd71520376dffc3c78	Spectrum
Predicted GC-MS	Sphinganine, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0uk9-4490200000-f4c4281643554b83dd43	Spectrum
Predicted GC-MS	Sphinganine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TBDMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TBDMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Sphinganine, TBDMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0iml-3791000000-013fe5eb404ccb287385	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-03di-9000000000-04469479cb6d83603093	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0bt9-9000000000-4f682b26d6efc1673141	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0udi-0009000000-4d5daf40edf51d7c5ce4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0f89-2196000000-86bd4d9593c5a53dfc94	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-01qa-9130000000-819bc3df8d7408799b9f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-03xr-9000000000-0b47410c79f07946095a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-03xr-9000000000-6dd6eb4c242974e7f7cc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	splash10-0ab9-3892000000-6d8fa67090a1cebaa6f3	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-0159-0092000000-6e15bf1516b938239cb5	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0udi-0009000000-4d5daf40edf51d7c5ce4	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0f89-2196000000-86bd4d9593c5a53dfc94	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-01qa-9130000000-819bc3df8d7408799b9f	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-03xr-9000000000-3157cbca45e3dce158e4	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-03xr-9000000000-6dd6eb4c242974e7f7cc	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - , positive	splash10-0udi-2390000000-a002411e49400899cf3c	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-0gx0-5096000000-ad6ab79ab16fab02d693	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Positive	splash10-08fr-9000000000-5afe9071156e7abc48f2	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 25V, Negative	splash10-0159-0092000000-9c001535e8080ffe05e2	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0fsi-0092000000-4cad101913d628c296ba	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0159-2290000000-e693ddcd90fd9234c669	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-06r7-9740000000-808c9a702fe97ec9078e	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-1089000000-00c77e7cc5d9f3475be7	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-115c-5091000000-dc391e96a566caaa0602	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9030000000-a74567f0d047f0915ffc	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, CD₃OD, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, CD₃OD, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Sphingolipid Metabolism
Gaucher Disease		Not Available
Globoid Cell Leukodystrophy		Not Available
Metachromatic Leukodystrophy (MLD)		Not Available
Fabry disease		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Lipid phosphate phosphohydrolase 2	PPAP2C	19p13	O43688	details
Lipid phosphate phosphohydrolase 1	PPAP2A	5q11	O14494	details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1	GBGT1	9q34.13-q34.3	Q8N5D6	details
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase	PIGL	17p12-p11.2	Q9Y2B2	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q	PIGQ	16p13.3	Q9BRB3	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A	PIGA	Xp22.1	P37287	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H	PIGH	14q24.1	Q14442	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	PIGP	21q22.2	P57054	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C	PIGC	1q23-q25	Q92535	details
Sphingosine kinase 1	SPHK1	17q25.2	Q9NYA1	details
Sphingosine kinase 2	SPHK2	19q13.2	Q9NRA0	details
Acid ceramidase	ASAH1	8p22	Q13510	details
Ganglioside GM2 activator	GM2A	5q33.1	P17900	details
T-cell surface glycoprotein CD1e, membrane-associated	CD1E	1q22-q23	P15812	details
Epididymal secretory protein E1	NPC2	14q24.3	P61916	details
Ceramide synthase 1	CERS1		P27544	details
Antigen-presenting glycoprotein CD1d	CD1D	1q22-q23	P15813	details
GPI mannosyltransferase 1	PIGM	1q23.2	Q9H3S5	details
Phosphatidylinositol-glycan biosynthesis class W protein	PIGW		Q7Z7B1	details
3-ketodihydrosphingosine reductase	KDSR	18q21.3	Q06136	details
Phosphatidylinositol-glycan biosynthesis class X protein	PIGX	3q29	Q8TBF5	details
GPI mannosyltransferase 4	PIGZ	3q29	Q86VD9	details
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase	B3GNT5	3q28	Q9BYG0	details
Beta-1,3-galactosyltransferase 5	B3GALT5	21q22.3	Q9Y2C3	details
GPI mannosyltransferase 3	PIGB	15q21-q22	Q92521	details
Phosphatidylinositol-glycan biosynthesis class F protein	PIGF	2p21-p16	Q07326	details
GPI ethanolamine phosphate transferase 2	PIGG	4p16.3	Q5H8A4	details
GPI ethanolamine phosphate transferase 1	PIGN	18q21.33	O95427	details
GPI ethanolamine phosphate transferase 3	PIGO	9p13.3	Q8TEQ8	details
GPI transamidase component PIG-S	PIGS	17p13.2	Q96S52	details
GPI transamidase component PIG-T	PIGT	20q12-q13.12	Q969N2	details
Phosphatidylinositol glycan anchor biosynthesis class U protein	PIGU	20q11.22	Q9H490	details
GPI mannosyltransferase 2	PIGV	1p36.11	Q9NUD9	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y	PIGY	4q22.1	Q3MUY2	details
Alkaline ceramidase 3	ACER3		Q9NUN7	details
Alkaline ceramidase 2	ACER2	9p22.1	Q5QJU3	details
Non-lysosomal glucosylceramidase	GBA2	9p13.3	Q9HCG7	details
Alkaline ceramidase 1	ACER1	19p13.3	Q8TDN7	details
Ceramide synthase 5	CERS5		Q8N5B7	details
GPI-anchor transamidase	PIGK	1p31.1	Q92643	details
Sphingosine-1-phosphate phosphatase 2	SGPP2		Q8IWX5	details
Ceramide synthase 2	CERS2		Q96G23	details
Ceramide synthase 3	CERS3		Q8IU89	details
Ceramide synthase 4	CERS4		Q9HA82	details
Ceramide synthase 6	CERS6		Q6ZMG9	details
Sphingosine-1-phosphate phosphatase 1	SGPP1		Q9BX95	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Pleckstrin homology domain-containing family A member 8	PLEKHA8	7p21-p11.2	Q96JA3	details
Protein PLEKHA9	PLEKHA9	12q	O95397	details
Glycolipid transfer protein domain-containing protein 2	GLTPD2	17p13.2	A6NH11	details
Putative uncharacterized protein PLEKHA8	PLEKHA8	7p21-p11.2	B5MDU3	details
Glycolipid transfer protein domain-containing protein 1	GLTPD1	1p36.33	Q5TA50	details
Putative uncharacterized protein DKFZp434L0435	DKFZp434L0435		Q9UFH6	details
Glycolipid transfer protein	GLTP	12q24.11	Q9NZD2	details

Metal Bindings

Not Available

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Lipid phosphate phosphohydrolase 1	PPAP2A	5q11	O14494	details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details
Sphingosine kinase 1	SPHK1	17q25.2	Q9NYA1	details
Sphingosine kinase 2	SPHK2	19q13.2	Q9NRA0	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details
Sphingosine kinase 1	SPHK1	17q25.2	Q9NYA1	details
Ceramide synthase 5	CERS5		Q8N5B7	details
Ceramide synthase 2	CERS2		Q96G23	details
Ceramide synthase 3	CERS3		Q8IU89	details
Ceramide synthase 4	CERS4		Q9HA82	details
Ceramide synthase 6	CERS6		Q6ZMG9	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000269

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Safingol

METLIN ID

Not Available

PubChem Compound

91486

PDB ID

Not Available

ChEBI ID

16566

References

General References

Not Available

Only showing the first 10 proteins. There are 65 proteins in total.

Show All

Enzymes

Enzyme Details

1. Lipid phosphate phosphohydrolase 2

General function:: Involved in catalytic activity
Specific function:: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
Gene Name:: PPAP2C
Uniprot ID:: O43688
Molecular weight:: 32573.435

Enzyme Details

2. Lipid phosphate phosphohydrolase 1

General function:: Involved in catalytic activity
Specific function:: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
Gene Name:: PPAP2A
Uniprot ID:: O14494
Molecular weight:: 32155.715

Enzyme Details

3. Lipid phosphate phosphohydrolase 3

General function:: Involved in catalytic activity
Specific function:: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
Gene Name:: PPAP2B
Uniprot ID:: O14495
Molecular weight:: 35115.61

Enzyme Details

4. Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens
Gene Name:: GBGT1
Uniprot ID:: Q8N5D6
Molecular weight:: 40126.9

Enzyme Details

5. N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

General function:: Involved in N-acetylglucosaminylphosphatidylinositol de
Specific function:: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Gene Name:: PIGL
Uniprot ID:: Q9Y2B2
Molecular weight:: 28530.965

Enzyme Details

6. Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

General function:: Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity
Specific function:: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:: PIGQ
Uniprot ID:: Q9BRB3
Molecular weight:: 65343.25

Enzyme Details

7. Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

General function:: Involved in biosynthetic process
Specific function:: Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Gene Name:: PIGA
Uniprot ID:: P37287
Molecular weight:: 54126.065

Enzyme Details

8. Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

General function:: Involved in phosphatidylinositol N-acetylglucosaminyltr
Specific function:: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:: PIGH
Uniprot ID:: Q14442
Molecular weight:: 21080.415

Enzyme Details

9. Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

General function:: Involved in phosphatidylinositol N-acetylglucosaminyltr
Specific function:: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:: PIGP
Uniprot ID:: P57054
Molecular weight:: 18089.055

Enzyme Details

10. Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

General function:: Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity
Specific function:: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:: PIGC
Uniprot ID:: Q92535
Molecular weight:: 33582.18

Transporters

Enzyme Details

1. Pleckstrin homology domain-containing family A member 8

General function:: Involved in glycolipid transporter activity
Specific function:: Involved in TGN-to-plasma membrane transport and in the formation of post-Golgi constitutive carriers. May play a role in ensuring the coordination of the budding and the fission reactions
Gene Name:: PLEKHA8
Uniprot ID:: Q96JA3
Molecular weight:: 58306.0

Enzyme Details

2. Protein PLEKHA9

General function:: Involved in glycolipid transporter activity
Specific function:: Not Available
Gene Name:: PLEKHA9
Uniprot ID:: O95397
Molecular weight:: 43538.3

Enzyme Details

3. Glycolipid transfer protein domain-containing protein 2

General function:: Involved in glycolipid transporter activity
Specific function:: Not Available
Gene Name:: GLTPD2
Uniprot ID:: A6NH11
Molecular weight:: 31641.2

Enzyme Details

4. Putative uncharacterized protein PLEKHA8

General function:: Involved in glycolipid transporter activity
Specific function:: Not Available
Gene Name:: PLEKHA8
Uniprot ID:: B5MDU3
Molecular weight:: 49308.8

Enzyme Details

5. Glycolipid transfer protein domain-containing protein 1

General function:: Involved in glycolipid transporter activity
Specific function:: Not Available
Gene Name:: GLTPD1
Uniprot ID:: Q5TA50
Molecular weight:: 24364.8

Enzyme Details

6. Putative uncharacterized protein DKFZp434L0435

General function:: Involved in glycolipid transporter activity
Specific function:: Not Available
Gene Name:: DKFZp434L0435
Uniprot ID:: Q9UFH6
Molecular weight:: 6175.1

Enzyme Details

7. Glycolipid transfer protein

General function:: Involved in glycolipid transporter activity
Specific function:: Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides
Gene Name:: GLTP
Uniprot ID:: Q9NZD2
Molecular weight:: 23849.6

Only showing the first 10 proteins. There are 65 proteins in total.

Show All

Showing Compound Card for Sphinganine (CDB004832)

Structure for CDB004832 (Sphinganine)

Enzymes

Transporters