| Identification |
|---|
| HMDB Protein ID
| CDBP00528 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase |
| Description
| Not Available |
| Synonyms
|
- PIG-L
- Phosphatidylinositol-glycan biosynthesis class L protein
|
| Gene Name
| PIGL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-acetylglucosaminylphosphatidylinositol de |
| Specific Function
| Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
|
| GO Classification
|
| Biological Process |
| C-terminal protein lipidation |
| preassembly of GPI anchor in ER membrane |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Molecular Function |
| N-acetylglucosaminylphosphatidylinositol deacetylase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | glycosylphosphatidylinositol-anchor biosynthesis | Not Available | Not Available | | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p12-p11.2 |
| SNPs
| PIGL |
| Gene Sequence
|
>759 bp
ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGG
GTTTGGGACTCCTCAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAA
AGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA
GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAAT
TACTACAATCAAGGAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGG
ATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGATGACCCAGGCATG
CAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATC
AATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTG
TATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGGTGCTCTGTGCTC
ACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCT
CTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAG
AAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTC
TCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 252 |
| Molecular Weight
| 28530.965 |
| Theoretical pI
| 8.111 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPT
VLGLARLRHWVYLLCFSAGNYYNQGETRKKELLQSCDVLGIPLSSVMIIDNRDFPDDPGM
QWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVL
TLQSVNVLRKYISLLDLPLSLLHTQDVLFVLNSKEVAQAKKAMSCHRSQLLWFRRLYIIF
SRYMRINSLSFL
|
| External Links |
|---|
| GenBank ID Protein
| 4239986 |
| UniProtKB/Swiss-Prot ID
| Q9Y2B2 |
| UniProtKB/Swiss-Prot Entry Name
| PIGL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB017165 |
| GeneCard ID
| PIGL |
| GenAtlas ID
| PIGL |
| HGNC ID
| HGNC:8966 |
| References |
|---|
| General References
| Not Available |