| Identification |
|---|
| HMDB Protein ID
| CDBP02216 |
| Secondary Accession Numbers
| Not Available |
| Name
| 3-ketodihydrosphingosine reductase |
| Description
| Not Available |
| Synonyms
|
- 3-dehydrosphinganine reductase
- FVT-1
- Follicular variant translocation protein 1
- KDS reductase
|
| Gene Name
| KDSR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
|
| GO Classification
|
| Biological Process |
| 3-keto-sphinganine metabolic process |
| phospholipid metabolic process |
| sphingolipid biosynthetic process |
| Cellular Component |
| extracellular space |
| integral to membrane |
| endoplasmic reticulum membrane |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| 3-dehydrosphinganine reductase activity |
| nucleotide binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Sphingolipid Metabolism |    |  | | Gaucher Disease |    | Not Available | | Globoid Cell Leukodystrophy |    | Not Available | | Metachromatic Leukodystrophy (MLD) |    | Not Available | | Fabry disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q21.3 |
| SNPs
| KDSR |
| Gene Sequence
|
>999 bp
ATGCTGCTGCTGGCTGCCGCCTTCCTCGTGGCCTTCGTGCTGCTGCTGTACATGGTGTCT
CCGCTCATCAGCCCCAAGCCCCTCGCCCTGCCCGGGGCGCATGTGGTGGTTACAGGAGGT
TCCAGTGGCATCGGGAAGTGCATTGCTATCGAGTGCTATAAACAAGGAGCTTTTATAACT
CTGGTTGCACGAAATGAGGATAAGCTGCTGCAGGCAAAGAAAGAAATTGAAATGCACTCT
ATTAATGACAAACAGGTGGTGCTTTGCATATCAGTTGATGTATCTCAAGACTATAACCAA
GTAGAGAATGTCATAAAACAAGCACAGGAGAAACTGGGTCCAGTGGACATGCTGGTAAAT
TGTGCAGGAATGGCAGTGTCAGGAAAATTTGAAGATCTTGAAGTTAGTACCTTTGAAAGG
TTAATGAGCATCAATTACCTGGGCAGCGTGTACCCCAGCCGGGCCGTGATCACCACCATG
AAGGAGCGCCGGGTGGGCAGGATCGTGTTTGTGTCCTCCCAGGCAGGACAGTTGGGATTA
TTCGGTTTCACAGCCTACTCTGCATCCAAGTTTGCCATAAGGGGATTGGCAGAAGCTTTG
CAGATGGAGGTGAAGCCATATAATGTCTACATCACAGTTGCTTACCCACCAGACACAGAC
ACACCTGGCTTTGCCGAAGAAAACAGAACAAAGCCTTTGGAGACTCGACTTATTTCAGAG
ACCACATCTGTGTGCAAACCAGAACAGGTGGCCAAACAAATTGTTAAAGATGCCATACAA
GGAAATTTCAACAGTTCCCTTGGCTCAGATGGGTACATGCTCTCGGCCCTGACCTGTGGG
ATGGCTCCAGTAACTTCTATTACTGAGGGGCTCCAGCAGGTGGTCACCATGGGCCTTTTC
CGCACTATTGCTTTGTTTTACCTTGGAAGTTTTGACAGCATAGTTCGTCGCTGCATGATG
CAGAGAGAAAAATCTGAAAATGCAGACAAAACTGCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 332 |
| Molecular Weight
| 36186.785 |
| Theoretical pI
| 7.126 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-ketodihydrosphingosine reductase
MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFIT
LVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVN
CAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGL
FGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISE
TTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLF
RTIALFYLGSFDSIVRRCMMQREKSENADKTA
|
| External Links |
|---|
| GenBank ID Protein
| 296186 |
| UniProtKB/Swiss-Prot ID
| Q06136 |
| UniProtKB/Swiss-Prot Entry Name
| KDSR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X63657 |
| GeneCard ID
| KDSR |
| GenAtlas ID
| KDSR |
| HGNC ID
| HGNC:4021 |
| References |
|---|
| General References
| Not Available |