Identification |
HMDB Protein ID
| CDBP02631 |
Secondary Accession Numbers
| Not Available |
Name
| Alkaline ceramidase 3 |
Description
| Not Available |
Synonyms
|
- AlkCDase 3
- Alkaline CDase 3
- Alkaline dihydroceramidase SB89
- Alkaline phytoceramidase
- aPHC
|
Gene Name
| ACER3 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
Specific Function
| Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.
|
GO Classification
|
Biological Process |
ceramide metabolic process |
positive regulation of cell proliferation |
phytosphingosine biosynthetic process |
phospholipid metabolic process |
sphingosine biosynthetic process |
Cellular Component |
integral to endoplasmic reticulum membrane |
integral to Golgi membrane |
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
catalytic activity |
hydrolase activity |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
Molecular Function |
phytoceramidase activity |
Process |
ceramide metabolic process |
sphingolipid metabolic process |
membrane lipid metabolic process |
primary metabolic process |
lipid metabolic process |
cellular lipid metabolic process |
sphingoid metabolic process |
metabolic process |
|
Cellular Location
|
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Sphingolipid Metabolism | | | Gaucher Disease | | Not Available | Globoid Cell Leukodystrophy | | Not Available | Metachromatic Leukodystrophy (MLD) | | Not Available | Fabry disease | | Not Available |
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| ACER3 |
Gene Sequence
|
>804 bp
ATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGACTGG
TGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTGGAATACAGTGAGTAAC
CTGATCATGATTATACCTCCAATGTTCGGTGCAATTCAGAGTGTTAGAGACGGTCTGGAA
AAACGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTC
CACATGACTCTGAAATATGAAATGCAGCTATTGGATGAACTCCCAATGATATACAGCTGT
TGCATATTTGTGTACTGCATGTTTGAATGTTTCAAGATCAAGAACTCAGTAAACTACCAT
CTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGGTAAAA
GAGCCAATATTCCATCAGGTCATGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCT
ATTTATATTGTTACATGGGTTTATCCATGGCTTAGAGGACTGGGTTATACATCATTGGGT
ATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCACTGAGG
AACTTTCGAAAGAAGGTACCACCTATCATAGGTATTACCACACAATTTCATGCATGGTGG
CATATTTTAACTGGCCTTGGTTCCTATCTTCACATCCTTTTCAGTTTGTATACAAGAACA
CTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTGATCCTG
TTTGAGCCTCTCAGGAAGCATTGA
|
Protein Properties |
Number of Residues
| 267 |
Molecular Weight
| Not Available |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Alkaline ceramidase 3
MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE
KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH
LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG
IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT
LYLRYRPKVKFLFGIWPVILFEPLRKH
|
External Links |
GenBank ID Protein
| 14669436 |
UniProtKB/Swiss-Prot ID
| Q9NUN7 |
UniProtKB/Swiss-Prot Entry Name
| ACER3_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF214454 |
GeneCard ID
| ACER3 |
GenAtlas ID
| ACER3 |
HGNC ID
| HGNC:16066 |
References |
General References
| Not Available |