Cannabis Compound Database: Showing Protein Alkaline ceramidase 1 (CDBP04663)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP04663

Secondary Accession Numbers

Not Available

Name

Alkaline ceramidase 1

Description

Not Available

Synonyms

Acylsphingosine deacylase 3
AlkCDase 1
Alkaline CDase 1
N-acylsphingosine amidohydrolase 3

Gene Name

ACER1

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity).

GO Classification

Biological Process
keratinocyte differentiation
phospholipid metabolic process
regulation of lipid metabolic process
response to alkalinity
sphingosine biosynthetic process
cellular response to calcium ion
ceramide catabolic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Molecular Function
dihydroceramidase activity
Process
sphingoid metabolic process
metabolic process
ceramide metabolic process
sphingolipid metabolic process
membrane lipid metabolic process
primary metabolic process
lipid metabolic process
cellular lipid metabolic process

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
Sphingolipid Metabolism
Gaucher Disease		Not Available
Globoid Cell Leukodystrophy		Not Available
Metachromatic Leukodystrophy (MLD)		Not Available
Fabry disease		Not Available

Gene Properties

Chromosome Location

Locus

19p13.3

SNPs

ACER1

Gene Sequence

>795 bp
ATGCCTAGCATCTTCGCCTATCAGAGCTCCGAGGTGGACTGGTGTGAGAGCAACTTCCAG
TACTCGGAGCTGGTGGCCGAGTTCTACAACACGTTCTCCAATATCCCCTTCTTCATCTTC
GGGCCACTGATGATGCTCCTGATGCACCCGTATGCCCAGAAGCGCTCCCGCTACATTTAC
GTTGTCTGGGTCCTCTTCATGATCATAGGCCTGTTCTCCATGTATTTCCACATGACGCTC
AGCTTCCTGGGCCAGCTGCTGGACGAGATCGCCATCCTGTGGCTCCTGGGCAGTGGCTAT
AGCATATGGATGCCCCGCTGCTATTTCCCCTCCTTCCTTGGGGGGAACAGGTCCCAGTTC
ATCCGCCTGGTCTTCATCACCACTGTGGTCAGCACCCTTCTGTCCTTCCTGCGGCCCACG
GTCAACGCCTACGCCCTCAACAGCATTGCCCTGCACATTCTCTACATCGTGTGCCAGGAG
TACAGGAAGACCAGCAATAAGGAGCTTCGGCACCTGATTGAGGTCTCCGTGGTTTTATGG
GCTGTTGCTCTGACCAGCTGGATCAGTGACCGTCTGCTTTGCAGCTTCTGGCAGAGGATT
CATTTCTTCTATCTGCACAGCATCTGGCATGTGCTCATCAGCATCACCTTCCCTTATGGC
ATGGTCACCATGGCCTTGGTGGATGCCAACTATGAGATGCCAGGTGAAACCCTCAAAGTC
CGCTACTGGCCTCGGGACAGTTGGCCCGTGGGGCTGCCCTACGTGGAAATCCGGGGTGAT
GACAAGGACTGCTGA

Protein Properties

Number of Residues

264

Molecular Weight

31095.165

Theoretical pI

7.133

Pfam Domain Function

aPHC (PF05875 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Alkaline ceramidase 1
MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIY
VVWVLFMIIGLFSMYFHMTLSFLGQLLDEIAILWLLGSGYSIWMPRCYFPSFLGGNRSQF
IRLVFITTVVSTLLSFLRPTVNAYALNSIALHILYIVCQEYRKTSNKELRHLIEVSVVLW
AVALTSWISDRLLCSFWQRIHFFYLHSIWHVLISITFPYGMVTMALVDANYEMPGETLKV
RYWPRDSWPVGLPYVEIRGDDKDC

External Links

GenBank ID Protein

19070367

UniProtKB/Swiss-Prot ID

Q8TDN7

UniProtKB/Swiss-Prot Entry Name

ACER1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF347024

GeneCard ID