| Identification |
|---|
| HMDB Protein ID
| CDBP05113 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sphingosine-1-phosphate phosphatase 2 |
| Description
| Not Available |
| Synonyms
|
- SPPase2
- Sphingosine-1-phosphatase 2
- Spp2
- hSPP2
|
| Gene Name
| SGPP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.
|
| GO Classification
|
| Biological Process |
| phospholipid metabolic process |
| sphingolipid biosynthetic process |
| sphingosine metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| Molecular Function |
| sphingosine-1-phosphate phosphatase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Sphingolipid Metabolism |    |  | | Gaucher Disease |    | Not Available | | Globoid Cell Leukodystrophy |    | Not Available | | Metachromatic Leukodystrophy (MLD) |    | Not Available | | Fabry disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| SGPP2 |
| Gene Sequence
|
>1200 bp
ATGGCCGAGCTGCTGCGGAGCCTGCAGGATTCCCAGCTCGTCGCCCGCTTCCAGCGCCGC
TGCGGGCTCTTCCCCGCTCCGGATGAAGGCCCCCGGGAGAACGGCGCGGACCCCACGGAG
CGCGCGGCGCGGGTCCCCGGGGTCGAGCATCTCCCCGCAGCCAACGGCAAGGGCGGCGAG
GCTCCGGCCAACGGGCTGCGCAGAGCCGCGGCGCCGGAGGCTTATGTACAGAAGTACGTC
GTGAAGAATTATTTCTACTATTACCTATTCCAATTTTCAGCTGCTTTGGGCCAAGAAGTG
TTCTACATCACGTTTCTTCCATTCACTCACTGGAATATTGACCCTTATTTATCCAGAAGA
TTGATCATCATATGGGTTTTGGTGATGTATATTGGCCAAGTGGCCAAGGATGTCTTGAAG
TGGCCCCGTCCCTCCTCCCCTCCAGTTGTAAAACTGGAAAAGAGACTGATCGCTGAATAT
GGAATGCCATCCACCCACGCCATGGCGGCCACTGCCATTGCCTTCACCCTCCTTATCTCT
ACTATGGACAGATACCAGTATCCATTTGTGTTGGGACTGGTGATGGCCGTGGTGTTTTCC
ACCTTGGTGTGTCTCAGCAGGCTCTACACTGGGATGCATACGGTCCTGGATGTGCTGGGT
GGCGTCCTGATCACCGCACTCCTCATCGTCCTCACCTACCCTGCCTGGACCTTCATCGAC
TGCCTGGACTCGGCCAGCCCCCTCTTCCCCGTGTGTGTCATAGTTGTGCCATTCTTCCTG
TGTTACAATTACCCTGTTTCTGATTACTACAGCCCAACCCGGGCGGACACCACCACCATT
CTGGCTGCCGGGGCTGGAGTGACCATAGGATTCTGGATCAACCATTTCTTCCAGCTTGTA
TCCAAGCCCGCTGAATCTCTCCCTGTTATTCAGAACATCCCACCACTCACCACCTACATG
TTAGTTTTGGGTCTGACCAAATTTGCAGTGGGAATTGTGTTGATCCTCTTGGTTCGTCAG
CTTGTACAAAATCTCTCACTGCAAGTATTATACTCATGGTTCAAGGTGGTCACCAGGAAC
AAGGAGGCCAGGCGGAGACTGGAGATTGAAGTGCCTTACAAGTTTGTTACCTACACATCT
GTTGGCATCTGCGCTACAACCTTTGTGCCGATGCTTCACAGGTTTCTGGGATTACCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 399 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sphingosine-1-phosphate phosphatase 2
MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGE
APANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRR
LIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLIS
TMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFID
CLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLV
SKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRN
KEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8IWX5 |
| UniProtKB/Swiss-Prot Entry Name
| SGPP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF542512 |
| GeneCard ID
| SGPP2 |
| GenAtlas ID
| SGPP2 |
| HGNC ID
| HGNC:19953 |
| References |
|---|
| General References
| Not Available |