Showing Compound Card for Copper (CDB005281)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraProtein targetPathwaysConcentrationsLinksReferencesenzymes (26)transporters (4) Show 76 proteinsXML
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Record Information
Version1.0
Created at2020-04-17 19:27:28 UTC
Updated at2020-12-07 19:11:53 UTC
CannabisDB IDCDB005281
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameCopper
DescriptionCopper, also known as cu(ii) or copper (II) ion, belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. Copper is a weakly acidic compound (based on its pKa). Copper exists in all living species, ranging from bacteria to humans. In humans, copper is involved in disulfiram action pathway. Outside of the human body, Copper has been detected, but not quantified in, several different foods, such as brussel sprouts, chicory roots, rosemaries, lemon grass, and roman camomiles. This could make copper a potential biomarker for the consumption of these foods. Copper is a potentially toxic compound. Copper, with regard to humans, has been found to be associated with several diseases such as mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma, occipital horn syndrome, and parkinson's disease; copper has also been linked to several inborn metabolic disorders including hyperzincaemia and hypercalprotectinaemia and menkes disease. Copper is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
COPPER (II) ionChEBI
Copper(II) cationChEBI
Copper, ion (cu2+)ChEBI
Cu(II)ChEBI
Cu2+ChEBI
Cu(2+)ChEBI
Cupric ionChEBI
CuHMDB
Chemical FormulaCu
Average Molecular Weight63.55
Monoisotopic Molecular Weight62.9296
IUPAC Namecopper(2+) ion
Traditional Namecopper(2+) ion
CAS Registry Number7440-50-8
SMILES
[Cu++]
InChI Identifier
InChI=1S/Cu/q+2
InChI KeyJPVYNHNXODAKFH-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous transition metal compounds
Sub ClassNot Available
Direct ParentHomogeneous transition metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous transition metal
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Environmental role:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point1083 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.16ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MSNot Available
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-9000000000-59c652eccc13cc365f652016-08-01View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-9000000000-59c652eccc13cc365f652016-08-01View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03di-9000000000-59c652eccc13cc365f652016-08-01View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-9000000000-9acd78ab9faeb89677a72016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-9000000000-9acd78ab9faeb89677a72016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-03di-9000000000-9acd78ab9faeb89677a72016-08-03View Spectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Transporters
Protein NameGene NameLocusUniprot IDDetails
Copper-transporting ATPase 2ATP7B13q14.3P35670 details
Copper-transporting ATPase 1ATP7AXq21.1Q04656 details
High affinity copper uptake protein 1SLC31A19q31-q32O15431 details
Probable low affinity copper uptake protein 2SLC31A29q31-q32O15432 details
Metal Bindings
Receptors
Protein NameGene NameLocusUniprot IDDetails
Amiloride-sensitive amine oxidase [copper-containing]ABP17q36.1P19801 details
Superoxide dismutase [Cu-Zn]SOD121q22.11P00441 details
Lysyl oxidase homolog 2LOXL28p21.3Q9Y4K0 details
Lysyl oxidase homolog 3LOXL32p13P58215 details
Lysyl oxidase homolog 4LOXL410q24Q96JB6 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Superoxide dismutase [Mn], mitochondrialSOD26q25.3P04179 details
Lysyl oxidase homolog 2LOXL28p21.3Q9Y4K0 details
Concentrations Data
Cannabis CultivarStatusValueReferenceDetails
Alien DawgDetected and Quantified0.002 mg/g dry wt
    • David S. Wishart,...
 details
GabriolaDetected and Quantified0.015 mg/g dry wt
    • David S. Wishart,...
 details
Island HoneyDetected and Quantified0.009 mg/g dry wt
    • David S. Wishart,...
 details
QuadraDetected and Quantified0.014 mg/g dry wt
    • David S. Wishart,...
 details
Sensi StarDetected and Quantified0.006 mg/g dry wt
    • David S. Wishart,...
 details
Tangerine DreamDetected and Quantified0.002 mg/g dry wt
    • David S. Wishart,...
 details
HMDB IDHMDB0000657
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB030749
KNApSAcK IDNot Available
Chemspider ID25221
KEGG Compound IDC00070
BioCyc IDCU%2b2
BiGG IDNot Available
Wikipedia LinkCopper
METLIN IDNot Available
PubChem Compound27099
PDB IDNot Available
ChEBI ID29036
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 76 proteins in total.

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Enzymes

Enzyme Details
1. Tyrosinase
General function:
Involved in oxidoreductase activity
Specific function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Gene Name:
TYR
Uniprot ID:
P14679
Molecular weight:
60392.69
Enzyme Details
2. Peptidyl-glycine alpha-amidating monooxygenase
General function:
Involved in monooxygenase activity
Specific function:
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Gene Name:
PAM
Uniprot ID:
P19021
Molecular weight:
108402.425
Enzyme Details
3. Dopamine beta-hydroxylase
General function:
Involved in monooxygenase activity
Specific function:
Conversion of dopamine to noradrenaline.
Gene Name:
DBH
Uniprot ID:
P09172
Molecular weight:
69064.45
Enzyme Details
4. Amiloride-sensitive amine oxidase [copper-containing]
General function:
Involved in copper ion binding
Specific function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
Gene Name:
ABP1
Uniprot ID:
P19801
Molecular weight:
85377.1
Enzyme Details
5. Membrane primary amine oxidase
General function:
Involved in copper ion binding
Specific function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.
Gene Name:
AOC3
Uniprot ID:
Q16853
Molecular weight:
84621.27
Enzyme Details
6. Retina-specific copper amine oxidase
General function:
Involved in copper ion binding
Specific function:
Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina.
Gene Name:
AOC2
Uniprot ID:
O75106
Molecular weight:
80515.11
Enzyme Details
7. Protein-lysine 6-oxidase
General function:
Involved in copper ion binding
Specific function:
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
Gene Name:
LOX
Uniprot ID:
P28300
Molecular weight:
46943.67
Enzyme Details
8. Cytochrome c oxidase subunit 1
General function:
Involved in iron ion binding
Specific function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Gene Name:
MT-CO1
Uniprot ID:
P00395
Molecular weight:
57040.91
Enzyme Details
9. Superoxide dismutase [Mn], mitochondrial
General function:
Involved in superoxide dismutase activity
Specific function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Gene Name:
SOD2
Uniprot ID:
P04179
Molecular weight:
24750.015
Enzyme Details
10. Superoxide dismutase [Cu-Zn]
General function:
Involved in metal ion binding
Specific function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Gene Name:
SOD1
Uniprot ID:
P00441
Molecular weight:
15935.685

Transporters

Enzyme Details
1. Copper-transporting ATPase 2
General function:
Involved in ATP binding
Specific function:
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Gene Name:
ATP7B
Uniprot ID:
P35670
Molecular weight:
157261.34
Enzyme Details
2. Copper-transporting ATPase 1
General function:
Involved in ATP binding
Specific function:
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Gene Name:
ATP7A
Uniprot ID:
Q04656
Molecular weight:
163372.275
Enzyme Details
3. High affinity copper uptake protein 1
General function:
Involved in copper ion transmembrane transporter activity
Specific function:
Involved in high-affinity copper uptake
Gene Name:
SLC31A1
Uniprot ID:
O15431
Molecular weight:
21090.5
Enzyme Details
4. Probable low affinity copper uptake protein 2
General function:
Involved in copper ion transmembrane transporter activity
Specific function:
Involved in low-affinity copper uptake (Potential)
Gene Name:
SLC31A2
Uniprot ID:
O15432
Molecular weight:
15681.3

Only showing the first 10 proteins. There are 76 proteins in total.

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