Showing Protein Proprotein convertase subtilisin/kexin type 7 (CDBP03148)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP03148
Secondary Accession Numbers Not Available
Name Proprotein convertase subtilisin/kexin type 7
Description Not Available
Synonyms
  1. Lymphoma proprotein convertase
  2. PC7
  3. PC8
  4. Prohormone convertase 7
  5. Proprotein convertase 7
  6. Proprotein convertase 8
  7. Subtilisin/kexin-like protease PC7
  8. hPC8
Gene Name PCSK7
Protein Type Enzyme
Biological Properties
General Function Involved in serine-type endopeptidase activity
Specific Function Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif
GO Classification
Function
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
endopeptidase activity
serine-type endopeptidase activity
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. Golgi apparatus
  2. Single-pass type I membrane protein
  3. trans-Golgi network membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q23-q24
SNPs PCSK7
Gene Sequence 
>2358 bp
ATGCCGAAGGGGAGGCAGAAAGTGCCACACTTGGATGCCCCCCTGGGCCTGCCCACCTGC
CTCTGGCTGGAATTAGCCGGGCTCTTCTTACTGGTTCCCTGGGTCATGGGCCTGGCAGGG
ACAGGTGGGCCTGATGGCCAGGGCACAGGGGGGCCGAGCTGGGCTGTGCACCTGGAAAGC
CTGGAAGGTGACGGGGAGGAAGAGACTCTGGAGCAGCAGGCGGATGCCTTGGCCCAGGCA
GCAGGGCTGGTGAATGCTGGACGCATCGGAGAGCTTCAGGGGCACTACCTCTTTGTCCAG
CCTGCTGGGCACAGGCCGGCCCTGGAGGTGGAGGCCATCCGGCAGCAGGTGGAGGCTGTG
TTGGCTGGGCATGAAGCTGTGCGCTGGCACTCAGAGCAGAGGCTGCTAAGGCGGGCCAAG
CGCAGCGTCCACTTCAACGACCCCAAGTACCCGCAGCAATGGCACCTGAATAACCGACGG
AGCCCGGGCAGGGACATCAACGTGACGGGTGTGTGGGAACGCAATGTGACTGGGCGAGGG
GTGACGGTGGTGGTAGTGGATGACGGAGTGGAACACACCATCCAGGACATTGCACCCAAC
TATAGCCCTGAGGGTAGCTATGACCTCAACTCTAATGACCCTGACCCCATGCCCCACCCG
GATGTGGAGAATGGCAACCACCATGGCACGCGATGTGCAGGAGAGATCGCGGCTGTGCCC
AACAACAGCTTCTGTGCCGTGGGCGTGGCCTACGGGAGCCGCATCGCAGGTATCCGGGTA
CTGGATGGACCTCTCACAGACAGCATGGAGGCAGTGGCGTTCAACAAGCACTATCAGATC
AATGACATCTACAGCTGCAGCTGGGGACCAGATGACGATGGGAAGACAGTGGATGGCCCC
CATCAGCTTGGAAAGGCTGCCTTACAACATGGGGTGATTGCTGGTCGCCAGGGCTTTGGG
AGCATCTTTGTGGTAGCCAGTGGCAACGGAGGCCAACACAACGACAACTGCAACTACGAT
GGCTACGCCAACTCCATCTACACCGTCACCATAGGAGCTGTGGATGAGGAGGGACGCATG
CCTTTCTATGCAGAAGAATGTGCCTCCATGCTGGCAGTCACCTTCAGTGGTGGGGACAAG
ATGCTTCGGAGCATTGTGACCACTGACTGGGACCTTCAGAAGGGCACTGGCTGCACTGAG
GGCCACACAGGGACCTCAGCTGCAGCGCCTCTGGCAGCTGGCATGATAGCCTTAATGCTG
CAGGTGCGGCCCTGCCTCACGTGGCGTGACGTCCAGCACATCATTGTCTTCACAGCCACC
CGGTATGAGGATCGCCGTGCAGAGTGGGTCACCAACGAGGCAGGCTTCAGCCATAGCCAC
CAGCACGGTTTCGGCCTCCTCAACGCCTGGAGGCTCGTGAATGCAGCCAAGATCTGGACA
TCTGTCCCTTACTTAGCATCCTACGTCAGTCCCGTGTTAAAAGAAAACAAGGCGATTCCG
CAGTCCCCCCGTTCCCTGGAGGTCCTGTGGAATGTCAGCAGGATGGACCTGGAGATGTCA
GGGCTGAAGACCCTGGAGCATGTGGCAGTGACAGTCTCCATCACTCACCCACGGCGCGGC
AGCTTGGAGCTGAAGCTGTTCTGCCCCAGTGGCATGATGTCCCTCATCGGCGCCCCCCGC
AGCATGGACTCGGATCCCAACGGCTTCAATGACTGGACCTTCTCCACTGTGCGATGCTGG
GGGGAGAGAGCCCGAGGGACCTACAGGCTTGTCATCAGGGATGTCGGGGATGAGTCATTC
CAGGTCGGCATCCTCCGGCAATGGCAGCTGACCCTATATGGCTCTGTGTGGAGTGCAGTA
GACATCAGGGACAGACAAAGGCTGTTAGAGAGTGCCATGAGTGGAAAATACCTGCACGAT
GACTTCGCCCTGCCCTGCCCACCGGGGCTGAAAATTCCTGAGGAAGATGGTTACACCATC
ACCCCCAACACCCTCAAGACCCTGGTGCTGGTAGGCTGTTTCACCGTCTTCTGGACTGTT
TACTACATGCTGGAAGTATATTTGAGCCAGAGGAATGTGGCTTCCAATCAAGTTTGTAGG
AGTGGACCCTGCCACTGGCCCCATCGGAGCCGGAAAGCCAAGGAGGAAGGGACAGAGCTA
GAATCAGTGCCACTTTGCAGCAGCAAGGATCCAGACGAAGTGGAAACAGAGAGCAGGGGC
CCTCCCACCACCTCTGACCTCCTTGCCCCAGACCTGCTGGAGCAAGGGGACTGGAGCCTG
TCCCAGAACAAGAGCGCCCTGGACTGCCCTCATCAGCACCTAGACGTACCGCACGGGAAG
GAGGAGCAGATCTGCTGA
Protein Properties
Number of Residues 785
Molecular Weight 86246.4
Theoretical pI 5.69
Pfam Domain Function
Signals
  • ["1-37"]
Transmembrane Regions
  • ["668-688"]
Protein Sequence 
>Proprotein convertase subtilisin/kexin type 7
MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
EEQIC
GenBank ID Protein 20336248
UniProtKB/Swiss-Prot ID Q16549
UniProtKB/Swiss-Prot Entry Name PCSK7_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004716.2
GeneCard ID PCSK7
GenAtlas ID PCSK7
HGNC ID HGNC:8748
References
General References Not Available