Identification
HMDB Protein ID CDBP02097
Secondary Accession Numbers Not Available
Name Membrane-bound transcription factor site-1 protease
Description Not Available
Synonyms
  1. Endopeptidase S1P
  2. SKI-1
  3. Subtilisin/kexin-isozyme 1
Gene Name MBTPS1
Protein Type Enzyme
Biological Properties
General Function Involved in serine-type endopeptidase activity
Specific Function Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu
GO Classification
Function
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
endopeptidase activity
serine-type endopeptidase activity
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. Golgi apparatus membrane
  2. Endoplasmic reticulum membrane
  3. Single-pass type I membrane protein
  4. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16|16q24
SNPs MBTPS1
Gene Sequence
>3159 bp
ATGAAGCTTGTCAACATCTGGCTGCTTCTGCTCGTGGTTTTGCTCTGTGGGAAGAAACAT
CTGGGCGACAGACTGGAAAAGAAATCTTTTGAAAAGGCCCCATGCCCTGGCTGTTCCCAC
CTGACTTTGAAGGTGGAATTCTCATCAACAGTTGTGGAATATGAATATATTGTGGCTTTC
AATGGATACTTTACAGCCAAAGCTAGAAATTCATTTATTTCAAGTGCCCTGAAGAGCAGT
GAAGTAGACAATTGGAGAATTATACCTCGAAACAATCCATCCAGTGACTACCCTAGTGAT
TTTGAGGTGATTCAGATAAAAGAAAAACAGAAAGCGGGGCTGCTAACACTTGAAGATCAT
CCAAACATCAAACGGGTCACGCCCCAACGAAAAGTCTTTCGTTCCCTCAAGTATGCTGAA
TCTGACCCCACAGTACCCTGCAATGAAACCCGGTGGAGCCAGAAGTGGCAATCATCACGT
CCCCTGCGAAGAGCCAGCCTCTCCCTGGGCTCTGGCTTCTGGCATGCTACGGGAAGGCAT
TCGAGCAGACGGCTGCTGAGAGCCATCCCGCGCCAGGTTGCCCAGACACTGCAGGCAGAT
GTGCTCTGGCAGATGGGATATACAGGTGCTAATGTAAGAGTTGCTGTTTTTGACACTGGG
CTGAGCGAGAAGCATCCCCACTTCAAAAATGTGAAGGAGAGAACCAACTGGACCAACGAG
CGAACGCTGGACGATGGGTTGGGCCATGGCACATTCGTGGCAGGTGTGATAGCCAGCATG
AGGGAGTGCCAAGGATTTGCTCCAGATGCAGAACTTCACATTTTCAGGGTCTTTACCAAT
AATCAGGTATCTTACACATCTTGGTTTTTGGACGCCTTCAACTATGCCATTTTAAAGAAG
ATCGACGTGTTAAACCTCAGCATCGGCGGCCCGGACTTCATGGATCATCCGTTTGTTGAC
AAGGTGTGGGAATTAACAGCTAACAATGTAATCATGGTTTCTGCTATTGGCAATGACGGA
CCTCTTTATGGCACTCTGAATAACCCTGCTGATCAAATGGATGTGATTGGAGTAGGCGGC
ATTGACTTTGAAGATAACATCGCCCGCTTTTCTTCAAGGGGAATGACTACCTGGGAGCTA
CCAGGAGGCTACGGTCGCATGAAACCTGACATTGTCACCTATGGTGCTGGCGTGCGGGGT
TCTGGCGTGAAAGGGGGGTGCCGGGCCCTCTCAGGGACCAGTGTTGCTTCTCCAGTGGTT
GCAGGTGCTGTCACCTTGTTAGTGAGCACAGTCCAGAAGCGTGAGCTGGTGAATCCCGCC
AGTATGAAGCAGGCCCTGATCGCGTCAGCCCGGAGGCTCCCCGGGGTCAACATGTTTGAG
CAAGGCCACGGCAAGCTCGATCTGCTCAGAGCCTATCAGATCCTCAACAGCTACAAGCCA
CAGGCAAGTTTGAGCCCCAGCTACATAGATCTGACTGAGTGTCCCTACATGTGGCCCTAC
TGCTCCCAGCCCATCTACTATGGAGGAATGCCGACAGTTGTTAATGTCACCATCCTCAAC
GGCATGGGAGTCACAGGAAGAATTGTAGATAAGCCTGACTGGCAGCCCTATTTGCCACAG
AACGGAGACAACATTGAAGTTGCCTTCTCCTACTCCTCGGTCTTATGGCCTTGGTCGGGC
TACCTGGCCATCTCCATTTCTGTGACCAAGAAAGCGGCTTCCTGGGAAGGCATTGCTCAG
GGCCATGTCATGATCACTGTGGCTTCCCCAGCAGAGACAGAGTCAAAAAATGGTGCAGAA
CAGACTTCAACAGTAAAGCTCCCCATTAAGGTGAAGATAATTCCTACTCCCCCGCGAAGC
AAGAGAGTTCTCTGGGATCAGTACCACAACCTCCGCTATCCACCTGGCTATTTCCCCAGG
GATAATTTAAGGATGAAGAATGACCCTTTAGACTGGAATGGTGATCACATCCACACCAAT
TTCAGGGATATGTACCAGCATCTGAGAAGCATGGGCTACTTTGTAGAGGTCCTCGGGGCC
CCCTTCACGTGTTTTGATGCCAGTCAGTATGGCACTTTGCTGATGGTGGACAGTGAGGAG
GAGTACTTCCCTGAAGAGATCGCCAAGCTCCGGAGGGACGTGGACAACGGCCTCTCGCTC
GTCATCTTCAGTGACTGGTACAACACTTCTGTTATGAGAAAAGTGAAGTTTTATGATGAA
AACACAAGGCAGTGGTGGATGCCGGATACCGGAGGAGCTAACATCCCAGCTCTGAATGAG
CTGCTGTCTGTGTGGAACATGGGGTTCAGCGATGGCCTGTATGAAGGGGAGTTCACCCTG
GCCAACCATGACATGTATTATGCGTCAGGGTGCAGCATCGCGAAGTTTCCAGAAGATGGC
GTCGTGATAACACAGACTTTCAAGGACCAAGGATTGGAGGTTTTAAAGCAGGAAACAGCA
GTTGTTGAAAACGTCCCCATTTTGGGACTTTATCAGATTCCAGCTGAGGGTGGAGGCCGG
ATTGTACTGTATGGGGACTCCAATTGCTTGGATGACAGTCACCGACAGAAGGACTGCTTT
TGGCTTCTGGATGCCCTCCTCCAGTACACATCGTATGGGGTGACACCGCCTAGCCTCAGT
CACTCTGGGAACCGCCAGCGCCCTCCCAGTGGAGCAGGCTCAGTCACTCCAGAGAGGATG
GAAGGAAACCATCTTCATCGGTACTCCAAGGTTCTGGAGGCCCATTTGGGAGACCCAAAA
CCTCGGCCTCTACCAGCCTGTCCACGCTTGTCTTGGGCCAAGCCACAGCCTTTAAACGAG
ACGGCGCCCAGTAACCTTTGGAAACATCAGAAGCTACTCTCCATTGACCTGGACAAGGTG
GTGTTACCCAACTTTCGATCGAATCGCCCTCAAGTGAGGCCCTTGTCCCCTGGAGAGAGC
GGCGCCTGGGACATTCCTGGAGGGATCATGCCTGGCCGCTACAACCAGGAGGTGGGCCAG
ACCATTCCTGTCTTTGCCTTCCTGGGAGCCATGGTGGTCCTGGCCTTCTTTGTGGTACAA
ATCAACAAGGCCAAGAGCAGGCCGAAGCGGAGGAAGCCCAGGGTGAAGCGCCCGCAGCTC
ATGCAGCAGGTTCACCCGCCAAAGACCCCTTCGGTGTGA
Protein Properties
Number of Residues 1052
Molecular Weight 117747.7
Theoretical pI 8.98
Pfam Domain Function
Signals
  • ["1-17"]
Transmembrane Regions
  • ["999-1021"]
Protein Sequence
>Membrane-bound transcription factor site-1 protease
MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF
NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH
PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH
SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE
RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK
IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG
IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV
AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP
QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ
NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE
QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN
FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL
VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL
ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR
IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM
EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV
VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ
INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
GenBank ID Protein 4506775
UniProtKB/Swiss-Prot ID Q14703
UniProtKB/Swiss-Prot Entry Name MBTP1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_003791.2
GeneCard ID MBTPS1
GenAtlas ID MBTPS1
HGNC ID HGNC:15456
References
General References Not Available