Identification |
HMDB Protein ID
| CDBP02097 |
Secondary Accession Numbers
| Not Available |
Name
| Membrane-bound transcription factor site-1 protease |
Description
| Not Available |
Synonyms
|
- Endopeptidase S1P
- SKI-1
- Subtilisin/kexin-isozyme 1
|
Gene Name
| MBTPS1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in serine-type endopeptidase activity |
Specific Function
| Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu |
GO Classification
|
Function |
catalytic activity |
hydrolase activity |
peptidase activity |
peptidase activity, acting on l-amino acid peptides |
endopeptidase activity |
serine-type endopeptidase activity |
Process |
metabolic process |
macromolecule metabolic process |
protein metabolic process |
proteolysis |
|
Cellular Location
|
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
- Single-pass type I membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 16|16q24 |
SNPs
| MBTPS1 |
Gene Sequence
|
>3159 bp
ATGAAGCTTGTCAACATCTGGCTGCTTCTGCTCGTGGTTTTGCTCTGTGGGAAGAAACAT
CTGGGCGACAGACTGGAAAAGAAATCTTTTGAAAAGGCCCCATGCCCTGGCTGTTCCCAC
CTGACTTTGAAGGTGGAATTCTCATCAACAGTTGTGGAATATGAATATATTGTGGCTTTC
AATGGATACTTTACAGCCAAAGCTAGAAATTCATTTATTTCAAGTGCCCTGAAGAGCAGT
GAAGTAGACAATTGGAGAATTATACCTCGAAACAATCCATCCAGTGACTACCCTAGTGAT
TTTGAGGTGATTCAGATAAAAGAAAAACAGAAAGCGGGGCTGCTAACACTTGAAGATCAT
CCAAACATCAAACGGGTCACGCCCCAACGAAAAGTCTTTCGTTCCCTCAAGTATGCTGAA
TCTGACCCCACAGTACCCTGCAATGAAACCCGGTGGAGCCAGAAGTGGCAATCATCACGT
CCCCTGCGAAGAGCCAGCCTCTCCCTGGGCTCTGGCTTCTGGCATGCTACGGGAAGGCAT
TCGAGCAGACGGCTGCTGAGAGCCATCCCGCGCCAGGTTGCCCAGACACTGCAGGCAGAT
GTGCTCTGGCAGATGGGATATACAGGTGCTAATGTAAGAGTTGCTGTTTTTGACACTGGG
CTGAGCGAGAAGCATCCCCACTTCAAAAATGTGAAGGAGAGAACCAACTGGACCAACGAG
CGAACGCTGGACGATGGGTTGGGCCATGGCACATTCGTGGCAGGTGTGATAGCCAGCATG
AGGGAGTGCCAAGGATTTGCTCCAGATGCAGAACTTCACATTTTCAGGGTCTTTACCAAT
AATCAGGTATCTTACACATCTTGGTTTTTGGACGCCTTCAACTATGCCATTTTAAAGAAG
ATCGACGTGTTAAACCTCAGCATCGGCGGCCCGGACTTCATGGATCATCCGTTTGTTGAC
AAGGTGTGGGAATTAACAGCTAACAATGTAATCATGGTTTCTGCTATTGGCAATGACGGA
CCTCTTTATGGCACTCTGAATAACCCTGCTGATCAAATGGATGTGATTGGAGTAGGCGGC
ATTGACTTTGAAGATAACATCGCCCGCTTTTCTTCAAGGGGAATGACTACCTGGGAGCTA
CCAGGAGGCTACGGTCGCATGAAACCTGACATTGTCACCTATGGTGCTGGCGTGCGGGGT
TCTGGCGTGAAAGGGGGGTGCCGGGCCCTCTCAGGGACCAGTGTTGCTTCTCCAGTGGTT
GCAGGTGCTGTCACCTTGTTAGTGAGCACAGTCCAGAAGCGTGAGCTGGTGAATCCCGCC
AGTATGAAGCAGGCCCTGATCGCGTCAGCCCGGAGGCTCCCCGGGGTCAACATGTTTGAG
CAAGGCCACGGCAAGCTCGATCTGCTCAGAGCCTATCAGATCCTCAACAGCTACAAGCCA
CAGGCAAGTTTGAGCCCCAGCTACATAGATCTGACTGAGTGTCCCTACATGTGGCCCTAC
TGCTCCCAGCCCATCTACTATGGAGGAATGCCGACAGTTGTTAATGTCACCATCCTCAAC
GGCATGGGAGTCACAGGAAGAATTGTAGATAAGCCTGACTGGCAGCCCTATTTGCCACAG
AACGGAGACAACATTGAAGTTGCCTTCTCCTACTCCTCGGTCTTATGGCCTTGGTCGGGC
TACCTGGCCATCTCCATTTCTGTGACCAAGAAAGCGGCTTCCTGGGAAGGCATTGCTCAG
GGCCATGTCATGATCACTGTGGCTTCCCCAGCAGAGACAGAGTCAAAAAATGGTGCAGAA
CAGACTTCAACAGTAAAGCTCCCCATTAAGGTGAAGATAATTCCTACTCCCCCGCGAAGC
AAGAGAGTTCTCTGGGATCAGTACCACAACCTCCGCTATCCACCTGGCTATTTCCCCAGG
GATAATTTAAGGATGAAGAATGACCCTTTAGACTGGAATGGTGATCACATCCACACCAAT
TTCAGGGATATGTACCAGCATCTGAGAAGCATGGGCTACTTTGTAGAGGTCCTCGGGGCC
CCCTTCACGTGTTTTGATGCCAGTCAGTATGGCACTTTGCTGATGGTGGACAGTGAGGAG
GAGTACTTCCCTGAAGAGATCGCCAAGCTCCGGAGGGACGTGGACAACGGCCTCTCGCTC
GTCATCTTCAGTGACTGGTACAACACTTCTGTTATGAGAAAAGTGAAGTTTTATGATGAA
AACACAAGGCAGTGGTGGATGCCGGATACCGGAGGAGCTAACATCCCAGCTCTGAATGAG
CTGCTGTCTGTGTGGAACATGGGGTTCAGCGATGGCCTGTATGAAGGGGAGTTCACCCTG
GCCAACCATGACATGTATTATGCGTCAGGGTGCAGCATCGCGAAGTTTCCAGAAGATGGC
GTCGTGATAACACAGACTTTCAAGGACCAAGGATTGGAGGTTTTAAAGCAGGAAACAGCA
GTTGTTGAAAACGTCCCCATTTTGGGACTTTATCAGATTCCAGCTGAGGGTGGAGGCCGG
ATTGTACTGTATGGGGACTCCAATTGCTTGGATGACAGTCACCGACAGAAGGACTGCTTT
TGGCTTCTGGATGCCCTCCTCCAGTACACATCGTATGGGGTGACACCGCCTAGCCTCAGT
CACTCTGGGAACCGCCAGCGCCCTCCCAGTGGAGCAGGCTCAGTCACTCCAGAGAGGATG
GAAGGAAACCATCTTCATCGGTACTCCAAGGTTCTGGAGGCCCATTTGGGAGACCCAAAA
CCTCGGCCTCTACCAGCCTGTCCACGCTTGTCTTGGGCCAAGCCACAGCCTTTAAACGAG
ACGGCGCCCAGTAACCTTTGGAAACATCAGAAGCTACTCTCCATTGACCTGGACAAGGTG
GTGTTACCCAACTTTCGATCGAATCGCCCTCAAGTGAGGCCCTTGTCCCCTGGAGAGAGC
GGCGCCTGGGACATTCCTGGAGGGATCATGCCTGGCCGCTACAACCAGGAGGTGGGCCAG
ACCATTCCTGTCTTTGCCTTCCTGGGAGCCATGGTGGTCCTGGCCTTCTTTGTGGTACAA
ATCAACAAGGCCAAGAGCAGGCCGAAGCGGAGGAAGCCCAGGGTGAAGCGCCCGCAGCTC
ATGCAGCAGGTTCACCCGCCAAAGACCCCTTCGGTGTGA
|
Protein Properties |
Number of Residues
| 1052 |
Molecular Weight
| 117747.7 |
Theoretical pI
| 8.98 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Membrane-bound transcription factor site-1 protease
MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF
NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH
PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH
SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE
RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK
IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG
IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV
AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP
QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ
NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE
QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN
FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL
VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL
ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR
IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM
EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV
VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ
INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
|
External Links |
GenBank ID Protein
| 4506775 |
UniProtKB/Swiss-Prot ID
| Q14703 |
UniProtKB/Swiss-Prot Entry Name
| MBTP1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_003791.2 |
GeneCard ID
| MBTPS1 |
GenAtlas ID
| MBTPS1 |
HGNC ID
| HGNC:15456 |
References |
General References
| Not Available |