Showing Compound Card for alpha-Linolenic acid (CDB000178)

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Record Information
Version1.0
Created at2020-03-18 23:27:40 UTC
Updated at2020-12-07 19:07:13 UTC
CannabisDB IDCDB000178
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common Namealpha-Linolenic acid
Descriptionalpha-Linolenic acid (ALA) is a polyunsaturated fatty acid (PUFA). It is a member of the group of essential fatty acids called omega-3 fatty acids. alpha-Linolenic acid is not synthesized by mammals and therefore is an essential dietary requirement for all mammals. Omega-3 fatty acids get their name based on the location of one of their first double bonds. In all omega-3 fatty acids, the first double bond is located between the third and fourth carbon atom counting from the methyl end of the fatty acid (n-3). Although humans and other mammals can synthesize saturated and some monounsaturated fatty acids from carbon groups in carbohydrates and proteins, they lack the enzymes necessary to insert a cis double bond at the n-6 or the n-3 position of a fatty acid. Certain nuts (English walnuts) and vegetable oils (canola, soybean, flaxseed/linseed, olive) are rich in alpha-linolenic acid. Linolenic acid is a fatty acid found in hemp seed oil of cannabis plants, first reported by Prior et al. in 1968 (PMID: 6991645 ). Omega-3 fatty acids like alpha-linolenic acid are important structural components of cell membranes. When incorporated into phospholipids, they affect cell membrane properties such as fluidity, flexibility, permeability, and the activity of membrane-bound enzymes. Omega-3 fatty acids can modulate the expression of several genes, including those involved with fatty acid metabolism and inflammation. alpha-Linolenic acid and other omega-3 fatty acids may regulate gene expression by interacting with specific transcription factors, including peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs). alpha-Linolenic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism. Patients with isovaleric acidemia have a defect in leucine catabolism resulting from a deficiency in the enzyme isovaleryl-CoA dehydrogenase. These patients do well on a low protein/low leucine diet but a low protein diet can lead to deficiencies in essential fatty acids, such as alpha-linolenic acid ( Ref:DOI ).
Structure
Thumb
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Synonyms
ValueSource
(9,12,15)-Linolenic acidChEBI
(9Z,12Z,15Z)-Octadecatrienoic acidChEBI
(Z,Z,Z)-9,12,15-Octadecatrienoic acidChEBI
9,12,15-Octadecatrienoic acidChEBI
9-cis,12-cis,15-cis-Octadecatrienoic acidChEBI
ALAChEBI
all-cis-9,12,15-Octadecatrienoic acidChEBI
cis,cis,cis-9,12,15-Octadecatrienoic acidChEBI
cis-Delta(9,12,15)-Octadecatrienoic acidChEBI
Linolenic acidChEBI
LinolenateKegg
alpha-LinolenateKegg
(9,12,15)-LinolenateGenerator
(9Z,12Z,15Z)-OctadecatrienoateGenerator
(Z,Z,Z)-9,12,15-OctadecatrienoateGenerator
9,12,15-OctadecatrienoateGenerator
9-cis,12-cis,15-cis-OctadecatrienoateGenerator
all-cis-9,12,15-OctadecatrienoateGenerator
cis,cis,cis-9,12,15-OctadecatrienoateGenerator
cis-delta(9,12,15)-OctadecatrienoateGenerator
cis-Δ(9,12,15)-octadecatrienoateGenerator
cis-Δ(9,12,15)-octadecatrienoic acidGenerator
a-LinolenateGenerator
a-Linolenic acidGenerator
Α-linolenateGenerator
Α-linolenic acidGenerator
alpha Linolenic acidMeSH
cis-9,12,15-OctadecatrienoateHMDB
cis-9,12,15-Octadecatrienoic acidHMDB
Industrene 120HMDB
FA(18:3(9Z,12Z,15Z))HMDB
FA(18:3n3)HMDB
Chemical FormulaC18H30O2
Average Molecular Weight278.43
Monoisotopic Molecular Weight278.2246
IUPAC Name(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
Traditional Nameα linolenic acid
CAS Registry Number463-40-1
SMILES
CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O
InChI Identifier
InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-
InChI KeyDTOSIQBPPRVQHS-PDBXOOCHSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as lineolic acids and derivatives. These are derivatives of lineolic acid. Lineolic acid is a polyunsaturated omega-6 18 carbon long fatty acid, with two CC double bonds at the 9- and 12-positions.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassLineolic acids and derivatives
Direct ParentLineolic acids and derivatives
Alternative Parents
Substituents
  • Octadecanoid
  • Long-chain fatty acid
  • Fatty acid
  • Unsaturated fatty acid
  • Straight chain fatty acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point-16.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logP6.46SANGSTER (1993)
Predicted Properties
PropertyValueSource
logP6.62ALOGPS
logP6.06ChemAxon
logS-6ALOGPS
pKa (Strongest Acidic)4.99ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 ŲChemAxon
Rotatable Bond Count13ChemAxon
Refractivity89.64 m³·mol⁻¹ChemAxon
Polarizability34.98 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
GC-MSalpha-Linolenic acid, 1 TMS, GC-MS Spectrumsplash10-052f-7900000000-8765cf82603feb1b448fSpectrum
GC-MSalpha-Linolenic acid, 1 TMS, GC-MS Spectrumsplash10-004i-9300000000-302519a616eaed5fcc59Spectrum
GC-MSalpha-Linolenic acid, 1 TMS, GC-MS Spectrumsplash10-005c-9800000000-2d44b3c70e2992b9a812Spectrum
GC-MSalpha-Linolenic acid, non-derivatized, GC-MS Spectrumsplash10-052f-7900000000-8765cf82603feb1b448fSpectrum
GC-MSalpha-Linolenic acid, non-derivatized, GC-MS Spectrumsplash10-004i-9300000000-302519a616eaed5fcc59Spectrum
GC-MSalpha-Linolenic acid, non-derivatized, GC-MS Spectrumsplash10-005c-9800000000-2d44b3c70e2992b9a812Spectrum
GC-MSalpha-Linolenic acid, non-derivatized, GC-MS Spectrumsplash10-052f-5900000000-28710ea35f196c595e03Spectrum
Predicted GC-MSalpha-Linolenic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-052e-6950000000-27037263e74c8119ead0Spectrum
Predicted GC-MSalpha-Linolenic acid, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00ds-6931000000-657fa0cc66a206a36409Spectrum
Predicted GC-MSalpha-Linolenic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-004i-0190000000-aee97e9ea2c7f0783adf2012-07-24View Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-05nb-9500000000-fb92aefc7010272393592012-07-24View Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-0aru-9100000000-a5dddfe6f629d1371fac2012-07-24View Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-004i-0090000000-2b7bea03a685454dd1352017-09-12View Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF , Negativesplash10-004i-0090000000-53ddfaed6ce13c37d9572017-09-12View Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 20V, Negativesplash10-004i-0090000000-e5350a66361bc63d10712017-09-12View Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 30V, Negativesplash10-004i-0090000000-5731aa5e301022c068132017-09-12View Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-004i-0091010000-6922411e48d747e592b52017-09-12View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-IT , negativesplash10-001i-0090000000-a18b573ad888d048efa62017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-TOF , negativesplash10-004i-0090000000-2b7bea03a685454dd1352017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-TOF , negativesplash10-004i-0090000000-e5350a66361bc63d10712017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-TOF , negativesplash10-004i-0090000000-5731aa5e301022c068132017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 10V, positivesplash10-004i-0090000000-1d391027db3704d71cb92020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 20V, positivesplash10-00lr-9210000000-41acd8a55f52afec6d792020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 40V, positivesplash10-014i-9000000000-a976b4a80a07eb2c46412020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-9100000000-497eddf5d738a45f83fb2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-004i-0090000000-0c00ca98901526cb2e262021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Negativesplash10-004i-1090000000-35ffce9343fe0d15ea0d2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Negativesplash10-004i-0090000000-373584fbab950d6676cc2021-09-20View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-01t9-0090000000-ae1f482177d0e208165e2017-07-26View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00o0-5690000000-20804c8382f14ff0ccf42017-07-26View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-014l-8930000000-9d5e342b1351adc71c202017-07-26View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004i-0090000000-4d3e8d1180800a7b4ed52017-07-26View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0059-1090000000-67ab14c068a142dd3c302017-07-26View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-9230000000-403c610d63380e63109a2017-07-26View Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR Spectrum (1D, 600 MHz, CDCl3, experimental)Spectrum
1D NMR13C NMR Spectrum (1D, 100 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 100 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 1000 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 1000 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 200 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 200 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 300 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 300 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 400 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 600 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 700 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 800 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 800 MHz, H2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 900 MHz, H2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 900 MHz, H2O, predicted)Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CDCl3, experimental)Spectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Calcium-dependent phospholipase A2PLA2G51p36-p34P39877 details
Group IIF secretory phospholipase A2PLA2G2F1p35Q9BZM2 details
Cytosolic phospholipase A2PLA2G4A1q25P47712 details
Phospholipase A2PLA2G1B12q23-q24.1P04054 details
Group XIIB secretory phospholipase A2-like proteinPLA2G12BQ9BX93 details
Group 10 secretory phospholipase A2PLA2G1016p13.1-p12O15496 details
Group IIE secretory phospholipase A2PLA2G2E1p36.13Q9NZK7 details
Group XIIA secretory phospholipase A2PLA2G12A4q25Q9BZM1 details
85/88 kDa calcium-independent phospholipase A2PLA2G622q13.1O60733 details
Phospholipase A2, membrane associatedPLA2G2A1p35P14555 details
Group IID secretory phospholipase A2PLA2G2D1p36.12Q9UNK4 details
Cytosolic phospholipase A2 gammaPLA2G4C19q13.3Q9UP65 details
Group 3 secretory phospholipase A2PLA2G322q12.2Q9NZ20 details
Bile acid-CoA:amino acid N-acyltransferaseBAAT9q22.3Q14032 details
Cytosolic acyl coenzyme A thioester hydrolaseACOT71p36O00154 details
Acyl-coenzyme A thioesterase 2, mitochondrialACOT214q24.3P49753 details
Acyl-coenzyme A thioesterase 4ACOT414q24.3Q8N9L9 details
Acyl-coenzyme A thioesterase 8ACOT820q13.12O14734 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Fatty acid desaturase 1FADS111q12.2-q13.1O60427 details
Fatty acid desaturase 2FADS211q12.2O95864 details
Elongation of very long chain fatty acids protein 4ELOVL46q14Q9GZR5 details
Phospholipase B1, membrane-associatedPLB12p23.2Q6P1J6 details
Cytosolic phospholipase A2 deltaPLA2G4D15q15.1Q86XP0 details
Cytosolic phospholipase A2 epsilonPLA2G4E15q15.1Q3MJ16 details
Cytosolic phospholipase A2 zetaPLA2G4F15q15.1Q68DD2 details
Cytosolic phospholipase A2 betaPLA2G4B15q11.2-q21.3P0C869 details
Acyl-coenzyme A thioesterase 1ACOT114q24.3Q86TX2 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Transient receptor potential cation channel subfamily V member 1TRPV117p13.2Q8NER1 details
Sodium/calcium exchanger 1SLC8A12p23-p22P32418 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Calcium-dependent phospholipase A2PLA2G51p36-p34P39877 details
Group IIF secretory phospholipase A2PLA2G2F1p35Q9BZM2 details
Phospholipase A2PLA2G1B12q23-q24.1P04054 details
Group XIIB secretory phospholipase A2-like proteinPLA2G12BQ9BX93 details
Group 10 secretory phospholipase A2PLA2G1016p13.1-p12O15496 details
Group IIE secretory phospholipase A2PLA2G2E1p36.13Q9NZK7 details
Group XIIA secretory phospholipase A2PLA2G12A4q25Q9BZM1 details
Phospholipase A2, membrane associatedPLA2G2A1p35P14555 details
Group IID secretory phospholipase A2PLA2G2D1p36.12Q9UNK4 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Fatty acid desaturase 1FADS111q12.2-q13.1O60427 details
Fatty acid desaturase 2FADS211q12.2O95864 details
Cytosolic phospholipase A2 deltaPLA2G4D15q15.1Q86XP0 details
Cytosolic phospholipase A2 epsilonPLA2G4E15q15.1Q3MJ16 details
Cytosolic phospholipase A2 zetaPLA2G4F15q15.1Q68DD2 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Phospholipase A2PLA2G1B12q23-q24.1P04054 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Transient receptor potential cation channel subfamily V member 1TRPV117p13.2Q8NER1 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Elongation of very long chain fatty acids protein 4ELOVL46q14Q9GZR5 details
Oxysterols receptor LXR-betaNR1H219q13.33P55055 details
Oxysterols receptor LXR-alphaNR1H311p11.2Q13133 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Phospholipase A2PLA2G1B12q23-q24.1P04054 details
Group 10 secretory phospholipase A2PLA2G1016p13.1-p12O15496 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Oxysterols receptor LXR-betaNR1H219q13.33P55055 details
Oxysterols receptor LXR-alphaNR1H311p11.2Q13133 details
Concentrations Data
Not Available
HMDB IDHMDB0001388
DrugBank IDDB00132
Phenol Explorer Compound IDNot Available
FoodDB IDFDB012462
KNApSAcK IDC00007247
Chemspider ID4444437
KEGG Compound IDC06427
BioCyc IDLINOLENIC_ACID
BiGG ID48237
Wikipedia LinkAlpha-Linolenic_acid
METLIN ID6208
PubChem Compound5280934
PDB IDNot Available
ChEBI ID27432
References
General References
  1. Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]

Only showing the first 10 proteins. There are 64 proteins in total.

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Enzymes

Enzyme Details
1. Calcium-dependent phospholipase A2
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Gene Name:
PLA2G5
Uniprot ID:
P39877
Molecular weight:
15674.065
Enzyme Details
2. Group IIF secretory phospholipase A2
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.
Gene Name:
PLA2G2F
Uniprot ID:
Q9BZM2
Molecular weight:
23256.29
Enzyme Details
3. Cytosolic phospholipase A2
General function:
Involved in metabolic process
Specific function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Name:
PLA2G4A
Uniprot ID:
P47712
Molecular weight:
85210.19
Enzyme Details
4. Phospholipase A2
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Gene Name:
PLA2G1B
Uniprot ID:
P04054
Molecular weight:
16359.535
Enzyme Details
5. Group XIIB secretory phospholipase A2-like protein
General function:
Involved in phospholipase A2 activity
Specific function:
Not known; does not seem to have catalytic activity.
Gene Name:
PLA2G12B
Uniprot ID:
Q9BX93
Molecular weight:
Not Available
Enzyme Details
6. Group 10 secretory phospholipase A2
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Gene Name:
PLA2G10
Uniprot ID:
O15496
Molecular weight:
18153.04
Enzyme Details
7. Group IIE secretory phospholipase A2
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Gene Name:
PLA2G2E
Uniprot ID:
Q9NZK7
Molecular weight:
15988.525
Enzyme Details
8. Group XIIA secretory phospholipase A2
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
Gene Name:
PLA2G12A
Uniprot ID:
Q9BZM1
Molecular weight:
21066.99
Enzyme Details
9. 85/88 kDa calcium-independent phospholipase A2
General function:
Involved in metabolic process
Specific function:
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
Gene Name:
PLA2G6
Uniprot ID:
O60733
Molecular weight:
84092.635
Enzyme Details
10. Phospholipase A2, membrane associated
General function:
Involved in phospholipase A2 activity
Specific function:
Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Gene Name:
PLA2G2A
Uniprot ID:
P14555
Molecular weight:
16082.525

Transporters

Enzyme Details
1. Transient receptor potential cation channel subfamily V member 1
General function:
Involved in ion channel activity
Specific function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL
Gene Name:
TRPV1
Uniprot ID:
Q8NER1
Molecular weight:
94955.3
Enzyme Details
2. Sodium/calcium exchanger 1
General function:
Involved in cell communication
Specific function:
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores
Gene Name:
SLC8A1
Uniprot ID:
P32418
Molecular weight:
108546.1

Only showing the first 10 proteins. There are 64 proteins in total.

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