| Identification |
|---|
| HMDB Protein ID
| CDBP00069 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phospholipase A2, membrane associated |
| Description
| Not Available |
| Synonyms
|
- GIIC sPLA2
- Group IIA phospholipase A2
- NPS-PLA2
- Non-pancreatic secretory phospholipase A2
- Phosphatidylcholine 2-acylhydrolase 2A
|
| Gene Name
| PLA2G2A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phospholipase A2 activity |
| Specific Function
| Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
|
| GO Classification
|
| Biological Process |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| positive regulation of inflammatory response |
| lipid catabolic process |
| low-density lipoprotein particle remodeling |
| positive regulation of macrophage derived foam cell differentiation |
| defense response to Gram-positive bacterium |
| phosphatidic acid biosynthetic process |
| phosphatidylglycerol acyl-chain remodeling |
| phosphatidylcholine acyl-chain remodeling |
| phosphatidylethanolamine acyl-chain remodeling |
| Cellular Component |
| endoplasmic reticulum membrane |
| secretory granule |
| extracellular space |
| Function |
| binding |
| catalytic activity |
| hydrolase activity |
| calcium ion binding |
| carboxylesterase activity |
| phospholipase a2 activity |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| Molecular Function |
| phospholipid binding |
| calcium-dependent phospholipase A2 activity |
| calcium ion binding |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| lipid catabolic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Peripheral membrane protein
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Linoleic acid metabolism | Not Available |  | | alpha-Linolenic acid metabolism | Not Available |  | | Vascular smooth muscle contraction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p35 |
| SNPs
| PLA2G2A |
| Gene Sequence
|
>435 bp
ATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGG
AATTTGGTGAATTTCCACAGAATGATCAAGTTGACGACAGGAAAGGAAGCCGCACTCAGT
TATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAACG
GATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGC
ACCAAATTTCTGAGCTACAAGTTTAGCAACTCGGGGAGCAGAATCACCTGTGCAAAACAG
GACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTAGA
AACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGC
ACCCCTCGTTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 144 |
| Molecular Weight
| 16082.525 |
| Theoretical pI
| 9.235 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phospholipase A2, membrane associated
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P14555 |
| UniProtKB/Swiss-Prot Entry Name
| PA2GA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M22430 |
| GeneCard ID
| PLA2G2A |
| GenAtlas ID
| PLA2G2A |
| HGNC ID
| HGNC:9031 |
| References |
|---|
| General References
| Not Available |