| Identification |
|---|
| HMDB Protein ID
| CDBP02419 |
| Secondary Accession Numbers
| Not Available |
| Name
| Elongation of very long chain fatty acids protein 4 |
| Description
| Not Available |
| Synonyms
|
- 3-keto acyl-CoA synthase ELOVL4
- ELOVL fatty acid elongase 4
- Very-long-chain 3-oxoacyl-CoA synthase 4
- ELOVL FA elongase 4
|
| Gene Name
| ELOVL4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled photoreceptor activity |
| Specific Function
| Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development.
|
| GO Classification
|
| Biological Process |
| fatty acid elongation, saturated fatty acid |
| very long-chain fatty acid biosynthetic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| Cellular Component |
| integral to endoplasmic reticulum membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Molecular Function |
| G-protein coupled photoreceptor activity |
| transferase activity |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fatty acid elongation | Not Available |  | | Alpha Linolenic Acid and Linoleic Acid Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q14 |
| SNPs
| ELOVL4 |
| Gene Sequence
|
>945 bp
ATGGGGCTCCTGGACTCGGAGCCGGGTAGTGTCCTAAACGTAGTGTCCACGGCACTCAAC
GACACGGTAGAGTTCTACCGCTGGACCTGGTCCATCGCAGATAAGCGTGTGGAAAATTGG
CCTCTGATGCAGTCTCCTTGGCCTACACTAAGTATAAGCACTCTTTATCTCCTGTTTGTG
TGGCTGGGTCCAAAATGGATGAAGGACCGAGAACCTTTTCAGATGCGTCTAGTGCTCATT
ATCTATAATTTTGGGATGGTTTTGCTTAACCTCTTTATCTTCAGAGAGTTATTCATGGGA
TCATATAATGCGGGATATAGCTATATTTGCCAGAGTGTGGATTATTCTAATAATGTTCAT
GAAGTCAGGATAGCTGCTGCTCTGTGGTGGTACTTTGTATCTAAAGGAGTTGAGTATTTG
GACACAGTGTTTTTTATTCTGAGAAAGAAAAACAACCAAGTTTCTTTCCTTCATGTGTAT
CATCACTGTACGATGTTTACCTTGTGGTGGATTGGAATTAAGTGGGTTGCAGGAGGACAA
GCATTTTTTGGAGCCCAGTTGAATTCCTTTATCCATGTGATTATGTACTCATACTATGGG
TTAACTGCATTTGGCCCATGGATTCAGAAATATCTTTGGTGGAAACGATACCTGACTATG
TTGCAACTGATTCAATTCCATGTGACCATTGGGCACACGGCACTGTCTCTTTACACTGAC
TGCCCCTTCCCCAAATGGATGCACTGGGCTCTAATTGCCTATGCAATCAGCTTCATATTT
CTCTTTCTTAACTTCTACATTCGGACATACAAAGAGCCTAAGAAACCAAAAGCTGGAAAA
ACAGCCATGAATGGTATTTCAGCAAATGGTGTGAGCAAATCAGAAAAACAACTCATGATA
GAAAATGGAAAAAAGCAGAAAAATGGAAAAGCAAAAGGAGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 314 |
| Molecular Weight
| 36828.905 |
| Theoretical pI
| 9.468 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Elongation of very long chain fatty acids protein 4
MGLLDSEPGSVLNVVSTALNDTVEFYRWTWSIADKRVENWPLMQSPWPTLSISTLYLLFV
WLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRELFMGSYNAGYSYICQSVDYSNNVH
EVRIAAALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYHHCTMFTLWWIGIKWVAGGQ
AFFGAQLNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYLTMLQLIQFHVTIGHTALSLYTD
CPFPKWMHWALIAYAISFIFLFLNFYIRTYKEPKKPKAGKTAMNGISANGVSKSEKQLMI
ENGKKQKNGKAKGD
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9GZR5 |
| UniProtKB/Swiss-Prot Entry Name
| ELOV4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF277094 |
| GeneCard ID
| ELOVL4 |
| GenAtlas ID
| ELOVL4 |
| HGNC ID
| HGNC:14415 |
| References |
|---|
| General References
| Not Available |