Cannabis Compound Database: Showing Protein Group IIE secretory phospholipase A2 (CDBP00063)

Identification Biological properties Gene properties Protein properties External links References XML Show 40 compounds

Identification

HMDB Protein ID

CDBP00063

Secondary Accession Numbers

Not Available

Name

Group IIE secretory phospholipase A2

Description

Not Available

Synonyms

GIIE sPLA2
Phosphatidylcholine 2-acylhydrolase 2E
sPLA2-IIE

Gene Name

PLA2G2E

Protein Type

Enzyme

Biological Properties

General Function

Involved in phospholipase A2 activity

Specific Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

GO Classification

Biological Process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
lipid catabolic process
inflammatory response
phosphatidic acid biosynthetic process
phosphatidylglycerol acyl-chain remodeling
Cellular Component
extracellular region
Function
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
calcium ion binding
carboxylesterase activity
phospholipase a2 activity
ion binding
Molecular Function
phospholipase A2 activity
calcium ion binding
Process
phospholipid metabolic process
metabolic process
primary metabolic process
lipid metabolic process
lipid catabolic process
organophosphate metabolic process

Cellular Location

Secreted

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycerophospholipid metabolism	Not Available
Ether lipid metabolism	Not Available
Linoleic acid metabolism	Not Available
alpha-Linolenic acid metabolism	Not Available
Vascular smooth muscle contraction	Not Available

Gene Properties

Chromosome Location

Locus

1p36.13

SNPs

PLA2G2E

Gene Sequence

>429 bp
ATGAAATCTCCCCACGTGCTGGTGTTCCTTTGCCTCCTGGTGGCTCTGGTCACCGGGAAC
CTGGTTCAGTTTGGGGTGATGATCGAGAAGATGACAGGCAAGTCCGCCCTGCAGTACAAC
GACTATGGCTGTTACTGCGGCATCGGTGGCTCCCACTGGCCGGTGGACCAGACTGACTGG
TGCTGCCACGCCCACGACTGCTGCTACGGGCGTCTGGAGAAGCTGGGCTGTGAGCCCAAA
CTGGAAAAGTATCTTTTCTCTGTCAGCGAACGTGGCATTTTCTGCGCCGGCAGGACCACC
TGCCAGCGGCTGACCTGCGAGTGTGACAAGAGGGCTGCCCTCTGCTTTCGCCGCAACCTG
GGCACCTACAACCGCAAATATGCCCATTATCCCAACAAGCTGTGCACCGGGCCCACCCCG
CCCTGCTGA

Protein Properties

Number of Residues

142

Molecular Weight

15988.525

Theoretical pI

8.223

Pfam Domain Function

Phospholip_A2_1 (PF00068 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Group IIE secretory phospholipase A2
MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDW
CCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNL
GTYNRKYAHYPNKLCTGPTPPC

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q9NZK7

UniProtKB/Swiss-Prot Entry Name

PA2GE_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF189279

GeneCard ID