Identification
HMDB Protein ID CDBP00061
Secondary Accession Numbers Not Available
Name Group 10 secretory phospholipase A2
Description Not Available
Synonyms
  1. GX sPLA2
  2. Group X secretory phospholipase A2
  3. Phosphatidylcholine 2-acylhydrolase 10
  4. sPLA2-X
Gene Name PLA2G10
Protein Type Enzyme
Biological Properties
General Function Involved in phospholipase A2 activity
Specific Function PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
GO Classification
Biological Process
positive regulation of lipid storage
positive regulation of prostaglandin secretion
axon guidance
arachidonic acid metabolic process
phosphatidic acid biosynthetic process
cholesterol homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
phosphatidylglycerol acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
regulation of macrophage activation
phosphatidylethanolamine acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
lipid catabolic process
positive regulation of macrophage derived foam cell differentiation
lysophospholipid transport
negative regulation of cholesterol efflux
positive regulation of arachidonic acid secretion
positive regulation of cellular protein metabolic process
Cellular Component
extracellular region
Function
calcium ion binding
carboxylesterase activity
phospholipase a2 activity
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
Molecular Function
phospholipase A2 activity
calcium ion binding
Process
metabolic process
primary metabolic process
lipid metabolic process
lipid catabolic process
organophosphate metabolic process
phospholipid metabolic process
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location 16
Locus 16p13.1-p12
SNPs PLA2G10
Gene Sequence
>498 bp
ATGGGGCCGCTACCTGTGTGCCTGCCAATCATGCTGCTCCTGCTACTGCCGTCGCTGCTG
CTGCTGCTGCTTCTACCTGGCCCCGGGTCCGGCGAGGCCTCCAGGATATTACGTGTGCAC
CGGCGTGGGATCCTGGAACTGGCAGGAACTGTGGGTTGTGTTGGTCCCCGAACCCCCATC
GCCTATATGAAATATGGTTGCTTTTGTGGCTTGGGAGGCCATGGCCAGCCCCGCGATGCC
ATTGACTGGTGCTGCCATGGCCACGACTGTTGTTACACTCGAGCTGAGGAGGCCGGCTGC
AGCCCCAAGACAGAGCGCTACTCCTGGCAGTGCGTCAATCAGAGCGTCCTGTGCGGACCG
GCAGAGAACAAATGCCAAGAACTGTTGTGCAAGTGTGACCAGGAGATTGCTAACTGCTTA
GCCCAAACTGAGTACAACTTAAAGTACCTCTTCTACCCCCAGTTCCTATGTGAGCCGGAC
TCGCCCAAGTGTGACTGA
Protein Properties
Number of Residues 165
Molecular Weight 18153.04
Theoretical pI 6.475
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Group 10 secretory phospholipase A2
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPI
AYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGP
AENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O15496
UniProtKB/Swiss-Prot Entry Name PA2GX_HUMAN
PDB IDs
GenBank Gene ID U95301
GeneCard ID PLA2G10
GenAtlas ID PLA2G10
HGNC ID HGNC:9029
References
General References Not Available