| Identification |
|---|
| HMDB Protein ID
| CDBP00061 |
| Secondary Accession Numbers
| Not Available |
| Name
| Group 10 secretory phospholipase A2 |
| Description
| Not Available |
| Synonyms
|
- GX sPLA2
- Group X secretory phospholipase A2
- Phosphatidylcholine 2-acylhydrolase 10
- sPLA2-X
|
| Gene Name
| PLA2G10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phospholipase A2 activity |
| Specific Function
| PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
|
| GO Classification
|
| Biological Process |
| positive regulation of lipid storage |
| positive regulation of prostaglandin secretion |
| axon guidance |
| arachidonic acid metabolic process |
| phosphatidic acid biosynthetic process |
| cholesterol homeostasis |
| negative regulation of sequence-specific DNA binding transcription factor activity |
| phosphatidylglycerol acyl-chain remodeling |
| phosphatidylcholine acyl-chain remodeling |
| regulation of macrophage activation |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| lipid catabolic process |
| positive regulation of macrophage derived foam cell differentiation |
| lysophospholipid transport |
| negative regulation of cholesterol efflux |
| positive regulation of arachidonic acid secretion |
| positive regulation of cellular protein metabolic process |
| Cellular Component |
| extracellular region |
| Function |
| calcium ion binding |
| carboxylesterase activity |
| phospholipase a2 activity |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| phospholipase A2 activity |
| calcium ion binding |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| lipid catabolic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Linoleic acid metabolism | Not Available |  | | alpha-Linolenic acid metabolism | Not Available |  | | Vascular smooth muscle contraction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p13.1-p12 |
| SNPs
| PLA2G10 |
| Gene Sequence
|
>498 bp
ATGGGGCCGCTACCTGTGTGCCTGCCAATCATGCTGCTCCTGCTACTGCCGTCGCTGCTG
CTGCTGCTGCTTCTACCTGGCCCCGGGTCCGGCGAGGCCTCCAGGATATTACGTGTGCAC
CGGCGTGGGATCCTGGAACTGGCAGGAACTGTGGGTTGTGTTGGTCCCCGAACCCCCATC
GCCTATATGAAATATGGTTGCTTTTGTGGCTTGGGAGGCCATGGCCAGCCCCGCGATGCC
ATTGACTGGTGCTGCCATGGCCACGACTGTTGTTACACTCGAGCTGAGGAGGCCGGCTGC
AGCCCCAAGACAGAGCGCTACTCCTGGCAGTGCGTCAATCAGAGCGTCCTGTGCGGACCG
GCAGAGAACAAATGCCAAGAACTGTTGTGCAAGTGTGACCAGGAGATTGCTAACTGCTTA
GCCCAAACTGAGTACAACTTAAAGTACCTCTTCTACCCCCAGTTCCTATGTGAGCCGGAC
TCGCCCAAGTGTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 165 |
| Molecular Weight
| 18153.04 |
| Theoretical pI
| 6.475 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Group 10 secretory phospholipase A2
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPI
AYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGP
AENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O15496 |
| UniProtKB/Swiss-Prot Entry Name
| PA2GX_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U95301 |
| GeneCard ID
| PLA2G10 |
| GenAtlas ID
| PLA2G10 |
| HGNC ID
| HGNC:9029 |
| References |
|---|
| General References
| Not Available |