Cannabis Compound Database: Showing Protein Group XIIA secretory phospholipase A2 (CDBP00065)

Identification Biological properties Gene properties Protein properties External links References XML Show 23 compounds

Identification

HMDB Protein ID

CDBP00065

Secondary Accession Numbers

Not Available

Name

Group XIIA secretory phospholipase A2

Description

Not Available

Synonyms

GXII sPLA2
Phosphatidylcholine 2-acylhydrolase 12A
sPLA2-XII

Gene Name

PLA2G12A

Protein Type

Enzyme

Biological Properties

General Function

Involved in phospholipase A2 activity

Specific Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

GO Classification

Biological Process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylglycerol acyl-chain remodeling
Cellular Component
endoplasmic reticulum
Golgi apparatus
extracellular region
Component
extracellular region
Function
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
calcium ion binding
carboxylesterase activity
phospholipase a2 activity
ion binding
cation binding
Molecular Function
calcium-dependent phospholipase A2 activity
calcium ion binding
Process
metabolic process
primary metabolic process
lipid metabolic process
lipid catabolic process
organophosphate metabolic process
phospholipid metabolic process

Cellular Location

Cytoplasm
Secreted

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycerophospholipid metabolism	Not Available
Ether lipid metabolism	Not Available
Linoleic acid metabolism	Not Available
alpha-Linolenic acid metabolism	Not Available
Vascular smooth muscle contraction	Not Available

Gene Properties

Chromosome Location

Locus

4q25

SNPs

PLA2G12A

Gene Sequence

>570 bp
ATGGCCCTGCTCTCGCGCCCCGCGCTCACCCTCCTGCTCCTCCTCATGGCCGCTGTTGTC
AGGTGCCAGGAGCAGGCCCAGACCACCGACTGGAGAGCCACCCTGAAGACCATCCGGAAC
GGCGTTCATAAGATAGACACGTACCTGAACGCCGCCTTGGACCTCCTGGGAGGCGAGGAC
GGTCTCTGCCAGTATAAATGCAGTGACGGATCTAAGCCTTTCCCACGTTATGGTTATAAA
CCCTCCCCACCGAATGGATGTGGCTCTCCACTGTTTGGTGTTCATCTTAACATTGGTATC
CCTTCCCTGACAAAGTGTTGCAACCAACACGACAGGTGCTATGAGACCTGTGGCAAAAGC
AAGAATGACTGTGATGAAGAATTCCAGTATTGCCTCTCCAAGATCTGCCGAGATGTACAG
AAAACACTAGGACTAACTCAGCATGTTCAGGCATGTGAAACAACAGTGGAGCTCTTGTTT
GACAGTGTTATACATTTAGGTTGTAAACCATATCTGGACAGCCAACGAGCCGCATGCAGG
TGTCATTATGAAGAAAAAACTGATCTTTAA

Protein Properties

Number of Residues

189

Molecular Weight

21066.99

Theoretical pI

7.237

Pfam Domain Function

PLA2G12 (PF06951 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Group XIIA secretory phospholipase A2
MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGED
GLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKS
KNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACR
CHYEEKTDL

External Links

GenBank ID Protein

12276062

UniProtKB/Swiss-Prot ID

Q9BZM1

UniProtKB/Swiss-Prot Entry Name

PG12A_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF306567

GeneCard ID