Identification |
HMDB Protein ID
| CDBP00065 |
Secondary Accession Numbers
| Not Available |
Name
| Group XIIA secretory phospholipase A2 |
Description
| Not Available |
Synonyms
|
- GXII sPLA2
- Phosphatidylcholine 2-acylhydrolase 12A
- sPLA2-XII
|
Gene Name
| PLA2G12A |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in phospholipase A2 activity |
Specific Function
| PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
|
GO Classification
|
Biological Process |
phosphatidylcholine acyl-chain remodeling |
phosphatidylethanolamine acyl-chain remodeling |
phosphatidylinositol acyl-chain remodeling |
phosphatidylserine acyl-chain remodeling |
lipid catabolic process |
phosphatidic acid biosynthetic process |
phosphatidylglycerol acyl-chain remodeling |
Cellular Component |
endoplasmic reticulum |
Golgi apparatus |
extracellular region |
Component |
extracellular region |
Function |
metal ion binding |
hydrolase activity, acting on ester bonds |
binding |
catalytic activity |
hydrolase activity |
calcium ion binding |
carboxylesterase activity |
phospholipase a2 activity |
ion binding |
cation binding |
Molecular Function |
calcium-dependent phospholipase A2 activity |
calcium ion binding |
Process |
metabolic process |
primary metabolic process |
lipid metabolic process |
lipid catabolic process |
organophosphate metabolic process |
phospholipid metabolic process |
|
Cellular Location
|
- Cytoplasm
- Secreted
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glycerophospholipid metabolism | Not Available | ![Map00564](https://www.genome.jp/kegg/misc/thumbnail/map00564.gif) | Ether lipid metabolism | Not Available | ![Map00565](https://www.genome.jp/kegg/misc/thumbnail/map00565.gif) | Linoleic acid metabolism | Not Available | ![Map00591](https://www.genome.jp/kegg/misc/thumbnail/map00591.gif) | alpha-Linolenic acid metabolism | Not Available | ![Map00592](https://www.genome.jp/kegg/misc/thumbnail/map00592.gif) | Vascular smooth muscle contraction | Not Available | ![Map04270](https://www.genome.jp/kegg/misc/thumbnail/map04270.gif) |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q25 |
SNPs
| PLA2G12A |
Gene Sequence
|
>570 bp
ATGGCCCTGCTCTCGCGCCCCGCGCTCACCCTCCTGCTCCTCCTCATGGCCGCTGTTGTC
AGGTGCCAGGAGCAGGCCCAGACCACCGACTGGAGAGCCACCCTGAAGACCATCCGGAAC
GGCGTTCATAAGATAGACACGTACCTGAACGCCGCCTTGGACCTCCTGGGAGGCGAGGAC
GGTCTCTGCCAGTATAAATGCAGTGACGGATCTAAGCCTTTCCCACGTTATGGTTATAAA
CCCTCCCCACCGAATGGATGTGGCTCTCCACTGTTTGGTGTTCATCTTAACATTGGTATC
CCTTCCCTGACAAAGTGTTGCAACCAACACGACAGGTGCTATGAGACCTGTGGCAAAAGC
AAGAATGACTGTGATGAAGAATTCCAGTATTGCCTCTCCAAGATCTGCCGAGATGTACAG
AAAACACTAGGACTAACTCAGCATGTTCAGGCATGTGAAACAACAGTGGAGCTCTTGTTT
GACAGTGTTATACATTTAGGTTGTAAACCATATCTGGACAGCCAACGAGCCGCATGCAGG
TGTCATTATGAAGAAAAAACTGATCTTTAA
|
Protein Properties |
Number of Residues
| 189 |
Molecular Weight
| 21066.99 |
Theoretical pI
| 7.237 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Group XIIA secretory phospholipase A2
MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGED
GLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKS
KNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACR
CHYEEKTDL
|
External Links |
GenBank ID Protein
| 12276062 |
UniProtKB/Swiss-Prot ID
| Q9BZM1 |
UniProtKB/Swiss-Prot Entry Name
| PG12A_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF306567 |
GeneCard ID
| PLA2G12A |
GenAtlas ID
| PLA2G12A |
HGNC ID
| HGNC:18554 |
References |
General References
| Not Available |