Cannabis Compound Database: Showing Compound Card for Adenosine 3',5'-diphosphate (CDB005149)

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Record Information

Version

1.0

Created at

2020-04-17 19:14:16 UTC

Updated at

2020-11-18 16:39:26 UTC

CannabisDB ID

CDB005149

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Adenosine 3',5'-diphosphate

Description

Adenosine 3',5'-diphosphate, also known as 3-phosphoadenosine 5-phosphate or 3'-phosphoadenylate, belongs to the class of organic compounds known as purine ribonucleoside 3',5'-bisphosphates. These are purine ribobucleotides with one phosphate group attached to 3' and 5' hydroxyl groups of the ribose moiety. Adenosine 3',5'-diphosphate is a strong basic compound (based on its pKa). Adenosine 3',5'-diphosphate exists in all living species, ranging from bacteria to humans. Outside of the human body, Adenosine 3',5'-diphosphate has been detected, but not quantified in, several different foods, such as scarlet beans, tronchuda cabbages, horseradish tree, shallots, and lindens. This could make adenosine 3',5'-diphosphate a potential biomarker for the consumption of these foods. An adenosine bisphosphate having two monophosphate groups at the 3'- and 5'-positions. Adenosine 3',5'-diphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
3'-Phosphoadenylate	ChEBI
Adenosine 3',5'-bisphosphate	ChEBI
PAP	ChEBI
Phosphoadenosine phosphate	ChEBI
3'-Phosphoadenylic acid	Generator
Adenosine 3',5'-bisphosphoric acid	Generator
Phosphoadenosine phosphoric acid	Generator
Adenosine 3',5'-diphosphoric acid	Generator
3'-Phosphoryl-AMP	HMDB
3,5-ADP	HMDB
3,5-Diphosphoadenosine	HMDB
3-Phosphoadenosine 5-phosphate	HMDB
5-(Dihydrogen phosphate) 3-adenylate	HMDB
5-(Dihydrogen phosphate)3'-adenylic acid	HMDB
Adenosine 3,5-bis	HMDB
Adenosine 3,5-bisphosphate	HMDB
Adenosine 3'-phosphate-5'-phosphate, disodium salt	HMDB
3'-Phosphoadenosine 5'-phosphate	HMDB
Adenosine 3'-phosphate-5'-phosphate, monosodium salt	HMDB
3',5'-ADP	HMDB
Adenosine 3'-phosphate-5'-phosphate	HMDB

Chemical Formula

C₁₀H₁₅N₅O₁₀P₂

Average Molecular Weight

427.2

Monoisotopic Molecular Weight

427.0294

IUPAC Name

{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}phosphonic acid

Traditional Name

adenosine 3',5'-bisphosphate

CAS Registry Number

1053-73-2

SMILES

NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1

InChI Identifier

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1

InChI Key

WHTCPDAXWFLDIH-KQYNXXCUSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside 3',5'-bisphosphates. These are purine ribobucleotides with one phosphate group attached to 3' and 5' hydroxyl groups of the ribose moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside 3',5'-bisphosphates

Alternative Parents

Substituents

Purine ribonucleoside 3',5'-bisphosphate
Purine ribonucleoside monophosphate
Pentose phosphate
Ribonucleoside 3'-phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-aminopurine
Pentose monosaccharide
Monosaccharide phosphate
Imidazopyrimidine
Purine
Aminopyrimidine
Monoalkyl phosphate
Organic phosphoric acid derivative
N-substituted imidazole
Phosphoric acid ester
Monosaccharide
Imidolactam
Pyrimidine
Alkyl phosphate
Imidazole
Azole
Tetrahydrofuran
Heteroaromatic compound
Secondary alcohol
Oxacycle
Azacycle
Organoheterocyclic compound
Amine
Alcohol
Organic nitrogen compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic oxygen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

adenosine bisphosphate (CHEBI:17985 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Placenta

Subcellular:

Organ and components:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	614.5 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-1.6	ALOGPS
logP	-4.8	ChemAxon
logS	-2.1	ALOGPS
pKa (Strongest Acidic)	0.7	ChemAxon
pKa (Strongest Basic)	3.92	ChemAxon
Physiological Charge	-4	ChemAxon
Hydrogen Acceptor Count	12	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	232.6 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	84.94 m³·mol⁻¹	ChemAxon
Polarizability	34.28 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Adenosine 3',5'-diphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9332100000-c2cf1343058e5c460684	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9141400000-8e8cf251eecd6d39cf02	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine 3',5'-diphosphate, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 10V, positive	splash10-000i-0913100000-4559e980fc823f06cda1	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 20V, positive	splash10-000i-0910000000-164b37f4075a5627b64d	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 40V, positive	splash10-000i-1900000000-0f28c9a19c771609202d	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-003r-3900000000-fc11f9ff14bc678ffb89	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-057i-2913300000-fdb650a7ed3a1d7dc119	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0059-9700000000-e0ed082bd1249fa162f6	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Positive	splash10-000i-1900000000-a2612ac21c9094d3d4b1	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-000i-0900000000-a48b75d77591f32a31a6	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0910000000-164b37f4075a5627b64d	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-000i-0913100000-5a86462d5152e2e074f0	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0101900000-c682799b7471e544d5a7	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-0902300000-77268ef9fe8672f81e9f	2015-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0900000000-6986eb10675f363acf42	2015-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-1900000000-493254661a51349997bd	2015-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-7801900000-b4b0af4deca129a6a12c	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0059-9800000000-4a1ffcf05d9938fe121e	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9200000000-fb4a5bf16d0e5bcaa1e0	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0900000000-63709bad7395f9f33acc	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-0900100000-1be0541745ea8310e717	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-003r-4901000000-46fabb89b3c8f5f65bc8	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-004i-0000900000-e292158e80c5681369df	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0019-0923500000-c2fa14d2158399b30f0c	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-001r-1779000000-aed0b018efcf2528cabd	2021-09-22	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Sulfate/Sulfite Metabolism
Sulfite oxidase deficiency		Not Available
Sphingolipid Metabolism
Gaucher Disease		Not Available
Globoid Cell Leukodystrophy		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Carbohydrate sulfotransferase 11	CHST11	12q	Q9NPF2	details
Carbohydrate sulfotransferase 3	CHST3	10q22.1	Q7LGC8	details
Carbohydrate sulfotransferase 13	CHST13	3q21.3	Q8NET6	details
Carbohydrate sulfotransferase 12	CHST12	7p22	Q9NRB3	details
Galactosylceramide sulfotransferase	GAL3ST1	22q12.2	Q99999	details
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1	HS3ST3B1	17p12	Q9Y662	details
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	17p12	Q9Y663	details
Sulfotransferase 1A1	SULT1A1	16p12.1	P50225	details
3'(2'),5'-bisphosphate nucleotidase 1	BPNT1	1q41	O95861	details
Heparan sulfate glucosamine 3-O-sulfotransferase 1	HS3ST1	4p16	O14792	details
Estrogen sulfotransferase	SULT1E1	4q13.1	P49888	details
Bile salt sulfotransferase	SULT2A1	19q13.3	Q06520	details
Carbohydrate sulfotransferase 1	CHST1	11p11.2	O43916	details
Heparan sulfate glucosamine 3-O-sulfotransferase 4	HS3ST4	16p11.2	Q9Y661	details
Sulfotransferase 1A2	SULT1A2	16p12.1	P50226	details
Heparan sulfate glucosamine 3-O-sulfotransferase 5	HS3ST5	6q21	Q8IZT8	details
Heparan sulfate glucosamine 3-O-sulfotransferase 2	HS3ST2	16p12	Q9Y278	details
Protein-tyrosine sulfotransferase 2	TPST2	22q12.1	O60704	details
Sulfotransferase family cytosolic 2B member 1	SULT2B1	19q13.3	O00204	details
Sulfotransferase 1A3/1A4	SULT1A3	16p11.2	P50224	details
Carbohydrate sulfotransferase 7	CHST7	Xp11.23	Q9NS84	details
Carbohydrate sulfotransferase 14	CHST14	15q15.1	Q8NCH0	details
Heparan-sulfate 6-O-sulfotransferase 1	HS6ST1	2q21	O60243	details
Heparan-sulfate 6-O-sulfotransferase 2	HS6ST2	Xq26.2	Q96MM7	details
Heparan-sulfate 6-O-sulfotransferase 3	HS6ST3	13q32.1	Q8IZP7	details
Carbohydrate sulfotransferase 15	CHST15	10q26	Q7LFX5	details
Inositol monophosphatase 3	IMPAD1	8q12.1	Q9NX62	details
Tyrosylprotein sulfotransferase 1	TPST1	7q11.21	A4D2M0	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
Heparan sulfate glucosamine 3-O-sulfotransferase 6	HS3ST6		Q96QI5	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	5q33.1	P52848	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2	NDST2	10q22	P52849	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3	NDST3	4q26	O95803	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4	NDST4	4q26	Q9H3R1	details
Sulfotransferase 1C3	SULT1C3	2q12.3	Q6IMI6	details
Sulfotransferase 6B1	SULT6B1		Q6IMI4	details
Protein-tyrosine sulfotransferase 1	TPST1	7q11.21	O60507	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Inositol monophosphatase 3	IMPAD1	8q12.1	Q9NX62	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Carbohydrate sulfotransferase 11	CHST11	12q	Q9NPF2	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	5q33.1	P52848	details

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000061

DrugBank ID

DB01812

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

159296

PDB ID

Not Available

ChEBI ID

17985

References

General References

Not Available

Only showing the first 10 proteins. There are 47 proteins in total.

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Enzymes

Enzyme Details

1. Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

General function:: Involved in catalytic activity
Specific function:: Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Gene Name:: ENPP1
Uniprot ID:: P22413
Molecular weight:: 104923.58

Enzyme Details

2. Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

General function:: Involved in catalytic activity
Specific function:: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity).
Gene Name:: ENPP3
Uniprot ID:: O14638
Molecular weight:: 100123.54

Enzyme Details

3. Carbohydrate sulfotransferase 11

General function:: Involved in sulfotransferase activity
Specific function:: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Gene Name:: CHST11
Uniprot ID:: Q9NPF2
Molecular weight:: 41002.97

Enzyme Details

4. Carbohydrate sulfotransferase 3

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.
Gene Name:: CHST3
Uniprot ID:: Q7LGC8
Molecular weight:: 54705.5

Enzyme Details

5. Carbohydrate sulfotransferase 13

General function:: Involved in sulfotransferase activity
Specific function:: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.
Gene Name:: CHST13
Uniprot ID:: Q8NET6
Molecular weight:: 38919.34

Enzyme Details

6. Carbohydrate sulfotransferase 12

General function:: Involved in sulfotransferase activity
Specific function:: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Gene Name:: CHST12
Uniprot ID:: Q9NRB3
Molecular weight:: 48413.945

Enzyme Details

7. Galactosylceramide sulfotransferase

General function:: Involved in galactosylceramide sulfotransferase activity
Specific function:: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).
Gene Name:: GAL3ST1
Uniprot ID:: Q99999
Molecular weight:: 48763.63

Enzyme Details

8. Heparan sulfate glucosamine 3-O-sulfotransferase 3B1

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Gene Name:: HS3ST3B1
Uniprot ID:: Q9Y662
Molecular weight:: 43323.605

Enzyme Details

9. Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Gene Name:: HS3ST3A1
Uniprot ID:: Q9Y663
Molecular weight:: 44899.155

Enzyme Details

10. Sulfotransferase 1A1

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Gene Name:: SULT1A1
Uniprot ID:: P50225
Molecular weight:: 34165.13

Only showing the first 10 proteins. There are 47 proteins in total.

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Showing Compound Card for Adenosine 3',5'-diphosphate (CDB005149)

Structure for CDB005149 (Adenosine 3',5'-diphosphate)

Enzymes