Identification
HMDB Protein ID CDBP00349
Secondary Accession Numbers Not Available
Name Sulfotransferase 1A3/1A4
Description Not Available
Synonyms
  1. Aryl sulfotransferase 1A3/1A4
  2. Catecholamine-sulfating phenol sulfotransferase
  3. HAST3
  4. M-PST
  5. Monoamine-sulfating phenol sulfotransferase
  6. Placental estrogen sulfotransferase
  7. ST1A3/ST1A4
  8. Sulfotransferase, monoamine-preferring
  9. TL-PST
  10. Thermolabile phenol sulfotransferase
Gene Name SULT1A3
Protein Type Enzyme
Biological Properties
General Function Involved in sulfotransferase activity
Specific Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
GO Classification
Biological Process
flavonoid metabolic process
sulfation
steroid metabolic process
xenobiotic metabolic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
catecholamine metabolic process
activation of signaling protein activity involved in unfolded protein response
Cellular Component
cytosol
Function
sulfotransferase activity
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
Molecular Function
aryl sulfotransferase activity
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 16
Locus 16p11.2
SNPs SULT1A3
Gene Sequence
>888 bp
ATGGAGCTGATCCAGGACACCTCCCGCCCGCCACTGGAGTACGTGAAGGGGGTCCCGCTC
ATCAAGTACTTTGCAGAGGCACTGGGGCCCCTGCAGAGCTTCCAAGCCCGACCTGATGAC
CTGCTCATCAACACCTACCCCAAGTCTGGCACCACCTGGGTGAGCCAGATACTGGACATG
ATCTACCAGGGCGGCGACCTAGAGAAGTGTAACCGGGCTCCCATCTACGTACGGGTGCCC
TTCCTTGAGGTCAATGATCCAGGGGAACCCTCAGGGCTGGAGACTCTGAAAGACACACCG
CCCCCACGGCTCATCAAGTCACACCTGCCCCTGGCTCTGCTCCCTCAGACTCTGTTGGAT
CAGAAGGTCAAGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTAC
CATTTCCACCGTATGGAAAAGGCGCACCCTGAGCCTGGGACCTGGGACAGCTTCCTGGAA
AAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGGTGG
GAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCC
AAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACCATG
GACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTAC
ACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATG
GCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTAT
GCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGA
Protein Properties
Number of Residues 295
Molecular Weight 34195.96
Theoretical pI 6.007
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Sulfotransferase 1A3/1A4
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDM
IYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLD
QKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNY
TTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P50224
UniProtKB/Swiss-Prot Entry Name ST1A3_HUMAN
PDB IDs
GenBank Gene ID L19956
GeneCard ID SULT1A3
GenAtlas ID SULT1A3
HGNC ID HGNC:30004
References
General References Not Available