| Identification |
|---|
| HMDB Protein ID
| CDBP02187 |
| Secondary Accession Numbers
| Not Available |
| Name
| Heparan-sulfate 6-O-sulfotransferase 1 |
| Description
| Not Available |
| Synonyms
|
- HS6ST-1
|
| Gene Name
| HS6ST1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
|
| GO Classification
|
| Biological Process |
| glycosaminoglycan biosynthetic process |
| heparan sulfate proteoglycan biosynthetic process, enzymatic modification |
| labyrinthine layer blood vessel development |
| angiogenesis |
| lung alveolus development |
| carbohydrate metabolic process |
| Cellular Component |
| Golgi membrane |
| integral to plasma membrane |
| Component |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| membrane part |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Molecular Function |
| sulfotransferase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| carbohydrate biosynthetic process |
|
| Cellular Location
|
- Membrane
- Single-pass type II membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q21 |
| SNPs
| HS6ST1 |
| Gene Sequence
|
>1236 bp
ATGCGGCGGCGGCGCGCCGGCGGCAGGACCATGGTTGAGCGCGCCAGCAAGTTCGTGCTG
GTGGTGGCGGGCTCGGTGTGCTTCATGCTCATCTTGTACCAGTACGCGGGCCCAGGACTG
AGCCTGGGCGCGCCCGGCGGCCGCGCGCCGCCCGACGACCTGGACCTGTTCCCCACACCC
GACCCCCACTACGAGAAGAAGTACTACTTCCCGGTCCGCGAGCTGGAGCGCTCGCTGCGC
TTCGACATGAAGGGCGACGACGTGATCGTCTTCCTGCACATCCAGAAGACGGGCGGCACC
ACCTTCGGCCGCCACCTCGTGCAGAACGTACGCCTCGAGGTGCCGTGCGACTGCCGGCCC
GGCCAGAAGAAGTGCACCTGCTACCGGCCCAACCGCCGCGAGACTTGGCTCTTCTCCCGC
TTCTCCACCGGCTGGAGCTGCGGGCTGCACGCCGACTGGACCGAGCTCACCAACTGCGTG
CCCGGCGTGCTGGACCGCCGCGACTCCGCCGCGCTGCGCACGCCCAGGAAGTTCTACTAC
ATCACCCTGCTACGAGACCCCGTGTCCCGCTACCTGAGCGAGTGGCGGCATGTGCAGAGG
GGTGCCACGTGGAAGACGTCGTTGCATATGTGTGATGGGCGCACGCCCACGCCTGAGGAG
CTGCCGCCCTGCTACGAGGGCACGGACTGGTCGGGCTGCACGCTACAGGAGTTCATGGAC
TGCCCGTACAACCTGGCCAACAACCGCCAGGTGCGCATGCTGGCCGACCTGAGCCTGGTG
GGCTGCTACAACCTGTCCTTCATCCCCGAGGGCAAGCGGGCCCAGCTGCTGCTCGAGAGC
GCCAAGAAGAACCTGCGGGGCATGGCCTTCTTCGGCCTGACCGAGTTCCAGCGCAAGACG
CAGTACCTGTTCGAGCGGACGTTCAACCTCAAGTTCATCCGGCCCTTCATGCAGTACAAT
AGCACGCGGGCGGGCGGCGTGGAGGTGGATGAAGACACCATCCGGCGCATCGAGGAGCTC
AACGACCTGGACATGCAGCTGTACGACTACGCCAAGGACCTCTTCCAGCAGCGCTACCAG
TACAAGCGGCAGCTGGAGCGCAGGGAGCAGCGCCTGAGGAGCCGCGAGGAGCGTCTGCTG
CACCGGGCCAAGGAGGCACTGCCGCGGGAGGATGCCGACGAGCCGGGCCGCGTGCCCACC
GAGGACTACATGAGCCACATCATTGAGAAGTGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 411 |
| Molecular Weight
| 48225.71 |
| Theoretical pI
| 8.796 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Heparan-sulfate 6-O-sulfotransferase 1
MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTP
DPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRP
GQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYY
ITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMD
CPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKT
QYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQ
YKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW
|
| External Links |
|---|
| GenBank ID Protein
| 148747866 |
| UniProtKB/Swiss-Prot ID
| O60243 |
| UniProtKB/Swiss-Prot Entry Name
| H6ST1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004807.2 |
| GeneCard ID
| HS6ST1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:5201 |
| References |
|---|
| General References
| Not Available |