Identification
HMDB Protein ID CDBP05408
Secondary Accession Numbers Not Available
Name Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
Description Not Available
Synonyms
  1. Glucosaminyl N-deacetylase/N-sulfotransferase 4
  2. N-heparan sulfate sulfotransferase 4
  3. NDST-4
  4. N-HSST 4
Gene Name NDST4
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).
GO Classification
Biological Process
heparan sulfate proteoglycan biosynthetic process
heparin biosynthetic process
Cellular Component
integral to membrane
Golgi membrane
Molecular Function
deacetylase activity
[heparan sulfate]-glucosamine N-sulfotransferase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 4
Locus 4q26
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 100714.905
Theoretical pI 7.55
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>gi|12007650|ref|NP_072091.1| bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 [Homo sapiens]
MNLIVKLRRSFRTLIVLLATFCLVSIVISAYFLYSGYKQEMTLIETTAEAECTDIKILPY
RSMELKTVKP
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9H3R1
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:20779
References
General References Not Available