| Identification |
|---|
| HMDB Protein ID
| CDBP00280 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carbohydrate sulfotransferase 11 |
| Description
| Not Available |
| Synonyms
|
- C4S-1
- C4ST-1
- C4ST1
- Chondroitin 4-O-sulfotransferase 1
- Chondroitin 4-sulfotransferase 1
|
| Gene Name
| CHST11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
|
| GO Classification
|
| Biological Process |
| negative regulation of apoptotic process |
| developmental growth |
| respiratory gaseous exchange |
| carbohydrate biosynthetic process |
| chondrocyte development |
| embryonic viscerocranium morphogenesis |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| polysaccharide localization |
| carbohydrate metabolic process |
| embryonic digit morphogenesis |
| post-embryonic development |
| chondroitin sulfate biosynthetic process |
| regulation of cell proliferation |
| Cellular Component |
| integral to membrane |
| Golgi membrane |
| Component |
| integral to membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Molecular Function |
| chondroitin 4-sulfotransferase activity |
| N-acetylgalactosamine 4-O-sulfotransferase activity |
| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| carbohydrate biosynthetic process |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | Not Available |  | | sulfur metabolism | Not Available |  | | Sulfate/Sulfite Metabolism |    | | | Sulfite oxidase deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q |
| SNPs
| CHST11 |
| Gene Sequence
|
>1059 bp
ATGAAGCCAGCGCTGCTGGAAGTGATGAGGATGAACAGAATCTGCCGGATGGTGCTGGCC
ACTTGCTTGGGATCCTTTATCCTGGTCATCTTCTATTTCCAAAGTATGTTGCACCCAGTC
ATGCGGAGGAATCCCTTTGGTGTGGACATCTGCTGCCGGAAGGGGTCCCGAAGCCCCCTG
CAGGAACTCTACAACCCAATCCAGCTGGAGCTCTCAAACACTGCTGTCCTGCACCAGATG
CGGCGGGACCAGGTGACAGACACGTGCCGAGCCAACAGCGCCACAAGCCGTAAGCGGAGG
GTGCTGACCCCCAACGACCTGAAGCACTTGGTGGTGGATGAGGACCACGAGCTCATCTAC
TGCTACGTGCCCAAGGTGGCCTGCACCAACTGGAAGCGGCTCATGATGGTCCTGACCGGG
CGGGGGAAGTACAGCGACCCCATGGAGATCCCGGCCAACGAGGCACACGTCTCCGCCAAC
CTGAAGACCCTGAACCAGTACAGCATCCCAGAAATCAACCACCGCTTGAAAAGCTACATG
AAGTTCCTGTTTGTCCGGGAGCCCTTCGAGAGGCTAGTGTCCGCCTACCGCAACAAGTTC
ACCCAGAAGTACAACATCTCCTTCCACAAGCGGTACGGCACCAAGATCATCAAACGCCAG
CGGAAGAACGCCACCCAGGAGGCCCTGCGCAAAGGGGACGATGTCAAATTCGAGGAGTTT
GTGGCCTATCTCATCGACCCACACACCCAGCGGGAGGAGCCTTTCAACGAACACTGGCAA
ACCGTCTACTCACTCTGCCATCCCTGCCACATCCACTATGACCTCGTGGGCAAGTACGAG
ACACTGGAAGAGGATTCTAATTACGTCCTGCAGCTGGCAGGAGTGGGCAGCTACCTGAAG
TTCCCCACCTATGCAAAGTCTACGAGAACTACTGATGAAATGACCACAGAATTCTTCCAG
AACATCAGCTCAGAGCACCAAACGCAGCTGTACGAAGTCTACAAACTCGATTTTTTAATG
TTCAATTACTCAGTGCCAAGCTACCTGAAATTGGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 352 |
| Molecular Weight
| 41002.97 |
| Theoretical pI
| 8.853 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carbohydrate sulfotransferase 11
MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPL
QELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRRVLTPNDLKHLVVDEDHELIY
CYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYM
KFLFVREPFERLVSAYRNKFTQKYNISFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEF
VAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLK
FPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE
|
| External Links |
|---|
| GenBank ID Protein
| 7768662 |
| UniProtKB/Swiss-Prot ID
| Q9NPF2 |
| UniProtKB/Swiss-Prot Entry Name
| CHSTB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB042326 |
| GeneCard ID
| CHST11 |
| GenAtlas ID
| CHST11 |
| HGNC ID
| HGNC:17422 |
| References |
|---|
| General References
| Not Available |