| Identification |
|---|
| HMDB Protein ID
| CDBP00335 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sulfotransferase 1A1 |
| Description
| Not Available |
| Synonyms
|
- Aryl sulfotransferase 1
- HAST1/HAST2
- P-PST 1
- Phenol sulfotransferase 1
- Phenol-sulfating phenol sulfotransferase 1
- ST1A1
- ST1A3
- Thermostable phenol sulfotransferase
- Ts-PST
|
| Gene Name
| SULT1A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
|
| GO Classification
|
| Biological Process |
| estrogen metabolic process |
| flavonoid metabolic process |
| sulfation |
| xenobiotic metabolic process |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| amine metabolic process |
| catecholamine metabolic process |
| Cellular Component |
| cytosol |
| Function |
| sulfotransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| Molecular Function |
| aryl sulfotransferase activity |
| flavonol 3-sulfotransferase activity |
| steroid sulfotransferase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | sulfur metabolism | Not Available |  | | Chemical carcinogenesis | Not Available |  | | Sulfate/Sulfite Metabolism |    | | | Sulfite oxidase deficiency |    | Not Available | | Tamoxifen Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p12.1 |
| SNPs
| SULT1A1 |
| Gene Sequence
|
>888 bp
ATGGAGCTGATCCAGGACACCTCCCGCCCGCCACTGGAGTACGTGAAGGGGGTCCCGCTC
ATCAAGTACTTTGCAGAGGCACTGGGGCCCCTGCAGAGCTTCCAGGCCCGGCCTGATGAC
CTGCTCATCAGCACCTACCCCAAGTCCGGCACCACCTGGGTGAGCCAGATTCTGGACATG
ATCTACCAGGGTGGTGACCTGGAGAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCC
TTCCTTGAGTTCAAAGCCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAGACACACCG
GCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGAT
CAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCAGTTTCCTACTAC
CACTTCTACCACATGGCCAAGGTGCACCCTGAGCCTGGGACCTGGGACAGCTTCCTGGAG
AAGTTCATGGTCGGAGAAGTGTCCTACGGATCCTGGTACCAGCACGTGCAGGAGTGGTGG
GAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCC
AAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCACTCCCTGCCAGAGGAGACCGTG
GACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTAC
ACCACCGTCCCCCAGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATG
GCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTAT
GCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 295 |
| Molecular Weight
| 34165.13 |
| Theoretical pI
| 6.624 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sulfotransferase 1A1
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDM
IYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLD
QKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDFMVQHTSFKEMKKNPMTNY
TTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
|
| External Links |
|---|
| GenBank ID Protein
| 21104442 |
| UniProtKB/Swiss-Prot ID
| P50225 |
| UniProtKB/Swiss-Prot Entry Name
| ST1A1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB062428 |
| GeneCard ID
| SULT1A1 |
| GenAtlas ID
| SULT1A1 |
| HGNC ID
| HGNC:11453 |
| References |
|---|
| General References
| Not Available |