| Identification |
|---|
| HMDB Protein ID
| CDBP00340 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bile salt sulfotransferase |
| Description
| Not Available |
| Synonyms
|
- DHEA-ST
- Dehydroepiandrosterone sulfotransferase
- HST
- Hydroxysteroid Sulfotransferase
- ST2
- ST2A1
- ST2A3
- Sulfotransferase 2A1
|
| Gene Name
| SULT2A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
|
| GO Classification
|
| Biological Process |
| sulfation |
| digestion |
| steroid metabolic process |
| xenobiotic metabolic process |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| bile acid catabolic process |
| cellular lipid metabolic process |
| Cellular Component |
| cytosol |
| Function |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| catalytic activity |
| Molecular Function |
| sulfotransferase activity |
| bile-salt sulfotransferase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Bile secretion | Not Available |  | | Chemical carcinogenesis | Not Available |  | | Acetaminophen Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.3 |
| SNPs
| SULT2A1 |
| Gene Sequence
|
>858 bp
ATGTCGGACGATTTCTTATGGTTTGAAGGCATAGCTTTCCCTACTATGGGTTTCAGATCC
GAAACCTTAAGAAAAGTACGTGATGAGTTCGTGATAAGGGATGAAGATGTAATAATATTG
ACTTACCCCAAATCAGGAACAAACTGGTTGGCTGAGATTCTCTGCCTGATGCACTCCAAG
GGGGATGCCAAGTGGATCCAATCTGTGCCCATCTGGGAGCGATCACCCTGGGTAGAGAGT
GAGATTGGGTATACAGCACTCAGTGAAACGGAGAGTCCACGTTTATTCTCCTCCCACCTC
CCCATCCAGTTATTCCCCAAGTCTTTCTTCAGTTCCAAGGCCAAGGTGATTTATCTCATG
AGAAATCCCAGAGATGTTTTGGTGTCTGGTTATTTTTTCTGGAAAAACATGAAGTTTATT
AAGAAACCAAAGTCATGGGAAGAATATTTTGAATGGTTTTGTCAAGGAACTGTGCTATAT
GGGTCATGGTTTGACCACATTCATGGCTGGATGCCCATGAGAGAGGAGAAAAACTTCCTG
TTACTGAGTTATGAGGAGCTGAAACAGGACACAGGAAGAACCATAGAGAAGATCTGTCAA
TTCCTGGGAAAGACGTTAGAACCCGAAGAACTGAACTTAATTCTCAAGAACAGCTCCTTT
CAGAGCATGAAAGAAAACAAGATGTCCAATTATTCCCTCCTGAGTGTTGATTATGTAGTG
GACAAAGCACAACTTCTGAGAAAAGGTGTATCTGGGGACTGGAAAAATCACTTCACAGTG
GCCCAAGCTGAAGACTTTGATAAATTGTTCCAAGAGAAGATGGCAGATCTTCCTCGAGAG
CTGTTCCCATGGGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 285 |
| Molecular Weight
| 33779.57 |
| Theoretical pI
| 5.951 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Bile salt sulfotransferase
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLM
RNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFL
LLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVV
DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE
|
| External Links |
|---|
| GenBank ID Protein
| 18088457 |
| UniProtKB/Swiss-Prot ID
| Q06520 |
| UniProtKB/Swiss-Prot Entry Name
| ST2A1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC020755 |
| GeneCard ID
| SULT2A1 |
| GenAtlas ID
| SULT2A1 |
| HGNC ID
| HGNC:11458 |
| References |
|---|
| General References
| Not Available |