Cannabis Compound Database: Showing Compound Card for Glycine (CDB006139)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (26)transporters (11) Show 49 proteins XML

Record Information

Version

1.0

Created at

2020-03-18 23:21:26 UTC

Updated at

2022-12-13 23:36:22 UTC

CannabisDB ID

CDB006139

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Glycine

Description

Glycine, also known as Gly or aminoacetic acid, belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Glycine is a very strong basic compound (based on its pKa). Glycine exists in all living species, ranging from bacteria to humans. Glycine is an odorless tasting compound. Outside of the human body, Glycine is found, on average, in the highest concentration within a few different foods, such as gelatins, gelatin desserts, and beluga whales and in a lower concentration in hedge mustards, pumpkinseed sunfish, and prunus (cherry, plum). Glycine has also been detected, but not quantified in, several different foods, such as boysenberries, fruit juices, giant butterburs, ginsengs, and Chinese mustards. Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the primarily involved. Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins. There are a number of reports supporting the role of supplementary glycine in prevention of many diseases and disorders including cancer. Dietary supplementation of glycine is effectual has been shown to be effective in treating metabolic disorders in patients with cardiovascular diseases ( PMID: 25332814 ), several inflammatory diseases, obesity, cancers, and diabetes ( PMID: 27292783 ). Glycine has also been shown to enhance the quality of sleep and neurological functions. (PMID: 28337245 )

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Aminoacetic acid	ChEBI
Aminoessigsaeure	ChEBI
Aminoethanoic acid	ChEBI
G	ChEBI
Gly	ChEBI
Glycin	ChEBI
Glycocoll	ChEBI
Glykokoll	ChEBI
Glyzin	ChEBI
H2N-CH2-COOH	ChEBI
Hgly	ChEBI
Leimzucker	ChEBI
Aminoacetate	Generator
Aminoethanoate	Generator
2-Aminoacetate	HMDB
2-Aminoacetic acid	HMDB
Aciport	HMDB
Amino-acetate	HMDB
Amino-acetic acid	HMDB
Glicoamin	HMDB
Glycolixir	HMDB
Glycosthene	HMDB
Gyn-hydralin	HMDB
Padil	HMDB
Glycine carbonate (1:1), monosodium salt	HMDB
Glycine carbonate (2:1), monopotassium salt	HMDB
Glycine sulfate (3:1)	HMDB
Glycine, monoammonium salt	HMDB
Glycine, monosodium salt	HMDB
Glycine, sodium hydrogen carbonate	HMDB
Monoammonium salt glycine	HMDB
Calcium salt glycine	HMDB
Glycine hydrochloride (2:1)	HMDB
Glycine phosphate (1:1)	HMDB
Glycine, monopotasssium salt	HMDB
Monopotasssium salt glycine	HMDB
Monosodium salt glycine	HMDB
Glycine carbonate (2:1), monolithium salt	HMDB
Glycine carbonate (2:1), monosodium salt	HMDB
Glycine hydrochloride	HMDB
Glycine, copper salt	HMDB
Hydrochloride, glycine	HMDB
Salt glycine, monoammonium	HMDB
Acid, aminoacetic	HMDB
Cobalt salt glycine	HMDB
Copper salt glycine	HMDB
Glycine phosphate	HMDB
Glycine, calcium salt	HMDB
Glycine, calcium salt (2:1)	HMDB
Glycine, cobalt salt	HMDB
Phosphate, glycine	HMDB
Salt glycine, monosodium	HMDB

Chemical Formula

C₂H₅NO₂

Average Molecular Weight

75.07

Monoisotopic Molecular Weight

75.032

IUPAC Name

2-aminoacetic acid

Traditional Name

glycine

CAS Registry Number

56-40-6

SMILES

NCC(O)=O

InChI Identifier

InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI Key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Alpha amino acids

Alternative Parents

Substituents

Alpha-amino acid
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Organic nitrogen compound
Organic oxide
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Primary aliphatic amine
Organic oxygen compound
Carbonyl group
Amine
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

alpha-amino acid (CHEBI:15428 )
proteinogenic amino acid (CHEBI:15428 )
serine family amino acid (CHEBI:15428 )
Common amino acids (C00037 )
Amino acids (C00037 )

Ontology

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Trace element

Molecular messenger:

Neurotransmitter

Industrial application:

Personal care products

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Antineoplastic agent:

Anticancer agent

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	262.2 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	249 mg/mL	Not Available
logP	-3.21	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-3.3	ALOGPS
logP	-3.4	ChemAxon
logS	0.87	ALOGPS
pKa (Strongest Acidic)	2.31	ChemAxon
pKa (Strongest Basic)	9.24	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	16 m³·mol⁻¹	ChemAxon
Polarizability	6.65 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-001i-9000000000-222d6c3a1ba6afcd7ea9	2014-09-20	View Spectrum
GC-MS	Glycine, 3 TMS, GC-MS Spectrum	splash10-00dj-2900000000-0ef96bcf06ce475afcdd	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-00dj-1900000000-1d289099ac79cfb8bb19	Spectrum
GC-MS	Glycine, 3 TMS, GC-MS Spectrum	splash10-00di-7910000000-6c972a683dfb75b69331	Spectrum
GC-MS	Glycine, 2 TMS, GC-MS Spectrum	splash10-0udi-0900000000-ef69e38ee6cebc2ece00	Spectrum
GC-MS	Glycine, 3 TMS, GC-MS Spectrum	splash10-00di-2910000000-3215b9e40f20c7b306cd	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-001i-9000000000-719b7f248956f13a312d	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-0udi-0900000000-99b4fc43740b21edc786	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-00di-1910000000-4cff4d14c73acff9442f	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-00dj-2900000000-0ef96bcf06ce475afcdd	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-00dj-1900000000-1d289099ac79cfb8bb19	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-0002-4960000000-2c6fa028e985c6019854	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-00di-7910000000-6c972a683dfb75b69331	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-00di-2910000000-3215b9e40f20c7b306cd	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-0udi-0900000000-ef69e38ee6cebc2ece00	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-00ds-2900000000-ffffed9c78c16a884e4a	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-004r-3900000000-f288b50b7b6890429811	Spectrum
GC-MS	Glycine, non-derivatized, GC-MS Spectrum	splash10-0udi-1900000000-c76140c31c1f120e4b9d	Spectrum
Predicted GC-MS	Glycine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-001i-9000000000-f0a2cfbefb9fcd9b6c3e	Spectrum
Predicted GC-MS	Glycine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00di-9300000000-b8bbfc1276d5adb1ba04	Spectrum
Predicted GC-MS	Glycine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glycine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glycine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glycine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-003r-9000000000-725357e461c898a7451e	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-9000000000-9f3930e66b117ad91dca	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-001i-9000000000-b3336097dddbb5e22871	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI RMU-6M) , Positive	splash10-001i-9000000000-719b7f248956f13a312d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-00di-9000000000-6001578fc511ba3fefef	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-00di-9000000000-79b2a0a9d93de6a62358	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-00di-9000000000-9290dbe208c4744f4431	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-004i-9000000000-342ab462db0835abb3d2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0ar1-9010000000-9daadc1d169a8530926d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-07y0-9220000000-8c7785f1f3aa8052679f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-0ula-9110000000-43ada06fe1b56b4e9fcc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-017i-9000000000-fbd78fbb48f082235f42	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-004i-9000000000-c38d0fb28793438083a9	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - DI-ESI-Q-Exactive Plus , Positive	splash10-004i-9000000000-18a7ae48c7b0e15cdf18	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-00di-9000000000-6001578fc511ba3fefef	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-00di-9000000000-79b2a0a9d93de6a62358	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-00di-9000000000-9290dbe208c4744f4431	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - , negative	splash10-00di-9000000000-605b44ac311a9af4bb7a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-004i-9000000000-342ab462db0835abb3d2	2017-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0059-9000000000-c6b1ebc1dba89b6a6184	2015-04-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001i-9000000000-851aa6a0263541a8b249	2015-04-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-053r-9000000000-d3b5624412082bb2cf60	2015-04-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-9000000000-89b2c043a5afe3ebc6f6	2015-04-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00di-9000000000-b4046e208ee8adb87021	2015-04-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-05fr-9000000000-36521e440c602bd2ca5a	2015-04-25	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 22.5 MHz, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Ammonia Recycling
Bile Acid Biosynthesis
Porphyrin Metabolism
Glutathione Metabolism
Glycine and Serine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	Xp11.21	P22557	details
5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	3p21.1	P13196	details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	22q13.1	O75600	details
Peroxisomal sarcosine oxidase	PIPOX	17q11.2	Q9P0Z9	details
D-amino-acid oxidase	DAO	12q24	P14920	details
Trifunctional purine biosynthetic protein adenosine-3	GART	21q22.11	P22102	details
Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	5p13	Q9BYV1	details
Glycine N-methyltransferase	GNMT	6p12	Q14749	details
Aminopeptidase N	ANPEP		P15144	details
Glycine amidinotransferase, mitochondrial	GATM	15q21.1	P50440	details
Bile acid-CoA:amino acid N-acyltransferase	BAAT	9q22.3	Q14032	details
Glycine--tRNA ligase	GARS	7p15	P41250	details
Aminomethyltransferase, mitochondrial	AMT	3p21.2-p21.1	P48728	details
Serine--pyruvate aminotransferase	AGXT	2q37.3	P21549	details
Glutathione synthetase	GSS	20q11.2	P48637	details
Serine hydroxymethyltransferase, mitochondrial	SHMT2	12q12-q14	P34897	details
Sarcosine dehydrogenase, mitochondrial	SARDH	9q33-q34	Q9UL12	details
Serine hydroxymethyltransferase, cytosolic	SHMT1	17p11.2	P34896	details
Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	9p22	P23378	details
Cytosol aminopeptidase	LAP3		P28838	details
Glycine cleavage system H protein, mitochondrial	GCSH		P23434	details
Vesicular inhibitory amino acid transporter	SLC32A1	20q11.23	Q9H598	details
Glycine N-acyltransferase	GLYAT	11q12.1	Q6IB77	details
Glycine N-acyltransferase-like protein 1	GLYATL1	11q12.1	Q969I3	details
Glycine N-acyltransferase-like protein 2	GLYATL2	11q12.1	Q8WU03	details
Kynurenine--oxoglutarate transaminase 3	CCBL2	1p22.2	Q6YP21	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Glutamate [NMDA] receptor subunit 3B	GRIN3B	19p13.3	O60391	details
Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	16p13.2	Q12879	details
Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	17q25	Q14957	details
Sodium- and chloride-dependent glycine transporter 1	SLC6A9	1p33	P48067	details
Sodium- and chloride-dependent glycine transporter 2	SLC6A5	11p15.1	Q9Y345	details
Proton-coupled amino acid transporter 1	SLC36A1	5q33.1	Q7Z2H8	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details
Glycine receptor subunit alpha-1	GLRA1	5q32	P23415	details
Glycine receptor subunit alpha-2	GLRA2		P23416	details
Glycine receptor subunit alpha-3	GLRA3	4q33-q34	O75311	details
Glycine receptor subunit beta	GLRB	4q31.3	P48167	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Trifunctional purine biosynthetic protein adenosine-3	GART	21q22.11	P22102	details
Aminopeptidase N	ANPEP		P15144	details
Cytosol aminopeptidase	LAP3		P28838	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aminopeptidase N	ANPEP		P15144	details
Glutamate [NMDA] receptor subunit 3B	GRIN3B	19p13.3	O60391	details
Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	16p13.2	Q12879	details
Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	17q25	Q14957	details
Glycine receptor subunit alpha-1	GLRA1	5q32	P23415	details
Glycine receptor subunit alpha-2	GLRA2		P23416	details
Glycine receptor subunit alpha-3	GLRA3	4q33-q34	O75311	details
Glycine receptor subunit beta	GLRB	4q31.3	P48167	details
N-arachidonyl glycine receptor	GPR18	13q32	Q14330	details

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.137 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.0932 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.0520 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.177 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.104 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.0849 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000123

DrugBank ID

DB00145

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

750

PDB ID

Not Available

ChEBI ID

15428

References

General References

Razak MA, Begum PS, Viswanath B, Rajagopal S: Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1. [PubMed:28337245 ]
McCarty MF, DiNicolantonio JJ: The cardiometabolic benefits of glycine: Is glycine an 'antidote' to dietary fructose? Open Heart. 2014 May 28;1(1):e000103. doi: 10.1136/openhrt-2014-000103. eCollection 2014. [PubMed:25332814 ]
Perez-Torres I, Zuniga-Munoz AM, Guarner-Lans V: Beneficial Effects of the Amino Acid Glycine. Mini Rev Med Chem. 2017;17(1):15-32. doi: 10.2174/1389557516666160609081602. [PubMed:27292783 ]

Only showing the first 10 proteins. There are 49 proteins in total.

Show All

Enzymes

Enzyme Details

1. 5-aminolevulinate synthase, erythroid-specific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS2
Uniprot ID:: P22557
Molecular weight:: 64632.86

Enzyme Details

2. 5-aminolevulinate synthase, nonspecific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS1
Uniprot ID:: P13196
Molecular weight:: 70580.325

Enzyme Details

3. 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

General function:: Involved in glycine C-acetyltransferase activity
Specific function:: Not Available
Gene Name:: GCAT
Uniprot ID:: O75600
Molecular weight:: 47973.79

Enzyme Details

4. Peroxisomal sarcosine oxidase

General function:: Involved in oxidoreductase activity
Specific function:: Metabolizes sarcosine, L-pipecolic acid and L-proline.
Gene Name:: PIPOX
Uniprot ID:: Q9P0Z9
Molecular weight:: 44065.515

Enzyme Details

5. D-amino-acid oxidase

General function:: Involved in D-amino-acid oxidase activity
Specific function:: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Gene Name:: DAO
Uniprot ID:: P14920
Molecular weight:: 39473.75

Enzyme Details

6. Trifunctional purine biosynthetic protein adenosine-3

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: GART
Uniprot ID:: P22102
Molecular weight:: 107766.295

Enzyme Details

7. Alanine--glyoxylate aminotransferase 2, mitochondrial

General function:: Involved in transaminase activity
Specific function:: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Gene Name:: AGXT2
Uniprot ID:: Q9BYV1
Molecular weight:: 57155.905

Enzyme Details

8. Glycine N-methyltransferase

General function:: Involved in folic acid binding
Specific function:: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Gene Name:: GNMT
Uniprot ID:: Q14749
Molecular weight:: 32742.0

Enzyme Details

9. Aminopeptidase N

General function:: Involved in proteolysis
Specific function:: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Gene Name:: ANPEP
Uniprot ID:: P15144
Molecular weight:: Not Available

Enzyme Details

10. Glycine amidinotransferase, mitochondrial

General function:: Amino acid transport and metabolism
Specific function:: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Name:: GATM
Uniprot ID:: P50440
Molecular weight:: 48455.01

Transporters

Enzyme Details

1. Glutamate [NMDA] receptor subunit 3B

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:: GRIN3B
Uniprot ID:: O60391
Molecular weight:: 112991.0

Enzyme Details

2. Glutamate [NMDA] receptor subunit epsilon-1

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits
Gene Name:: GRIN2A
Uniprot ID:: Q12879
Molecular weight:: 165281.2

Enzyme Details

3. Glutamate [NMDA] receptor subunit epsilon-3

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:: GRIN2C
Uniprot ID:: Q14957
Molecular weight:: 134531.1

Enzyme Details

4. Sodium- and chloride-dependent glycine transporter 1

General function:: Involved in neurotransmitter:sodium symporter activity
Specific function:: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
Gene Name:: SLC6A9
Uniprot ID:: P48067
Molecular weight:: 70582.02

Enzyme Details

5. Sodium- and chloride-dependent glycine transporter 2

General function:: Involved in neurotransmitter:sodium symporter activity
Specific function:: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.
Gene Name:: SLC6A5
Uniprot ID:: Q9Y345
Molecular weight:: 87433.13

Enzyme Details

6. Proton-coupled amino acid transporter 1

General function:: Amino acid transport and metabolism
Specific function:: Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid
Gene Name:: SLC36A1
Uniprot ID:: Q7Z2H8
Molecular weight:: 53075.0

Enzyme Details

7. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Enzyme Details

8. Glycine receptor subunit alpha-1

General function:: Involved in ion transport
Specific function:: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:: GLRA1
Uniprot ID:: P23415
Molecular weight:: 52623.4

Enzyme Details

9. Glycine receptor subunit alpha-2

General function:: Involved in ion transport
Specific function:: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:: GLRA2
Uniprot ID:: P23416
Molecular weight:: 52001.6

Enzyme Details

10. Glycine receptor subunit alpha-3

General function:: Involved in ion transport
Specific function:: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:: GLRA3
Uniprot ID:: O75311
Molecular weight:: 53799.8

Only showing the first 10 proteins. There are 49 proteins in total.

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Showing Compound Card for Glycine (CDB006139)

Structure for CDB006139 (Glycine)

Enzymes

Transporters