Record Information
Version1.0
Created at2020-03-18 23:21:26 UTC
Updated at2020-12-07 19:06:54 UTC
CannabisDB IDCDB006139
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameGlycine
DescriptionGlycine, also known as Gly or aminoacetic acid, belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Glycine is a very strong basic compound (based on its pKa). Glycine exists in all living species, ranging from bacteria to humans. Glycine is an odorless tasting compound. Outside of the human body, Glycine is found, on average, in the highest concentration within a few different foods, such as gelatins, gelatin desserts, and beluga whales and in a lower concentration in hedge mustards, pumpkinseed sunfish, and prunus (cherry, plum). Glycine has also been detected, but not quantified in, several different foods, such as boysenberries, fruit juices, giant butterburs, ginsengs, and Chinese mustards. Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the primarily involved. Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins. There are a number of reports supporting the role of supplementary glycine in prevention of many diseases and disorders including cancer. Dietary supplementation of glycine is effectual has been shown to be effective in treating metabolic disorders in patients with cardiovascular diseases ( PMID: 25332814 ), several inflammatory diseases, obesity, cancers, and diabetes ( PMID: 27292783 ). Glycine has also been shown to enhance the quality of sleep and neurological functions. (PMID: 28337245 )
Structure
Thumb
Synonyms
ValueSource
Aminoacetic acidChEBI
AminoessigsaeureChEBI
Aminoethanoic acidChEBI
GChEBI
GlyChEBI
GlycinChEBI
GlycocollChEBI
GlykokollChEBI
GlyzinChEBI
H2N-CH2-COOHChEBI
HglyChEBI
LeimzuckerChEBI
AminoacetateGenerator
AminoethanoateGenerator
2-AminoacetateHMDB
2-Aminoacetic acidHMDB
AciportHMDB
Amino-acetateHMDB
Amino-acetic acidHMDB
GlicoaminHMDB
GlycolixirHMDB
GlycostheneHMDB
Gyn-hydralinHMDB
PadilHMDB
Glycine carbonate (1:1), monosodium saltHMDB
Glycine carbonate (2:1), monopotassium saltHMDB
Glycine sulfate (3:1)HMDB
Glycine, monoammonium saltHMDB
Glycine, monosodium saltHMDB
Glycine, sodium hydrogen carbonateHMDB
Monoammonium salt glycineHMDB
Calcium salt glycineHMDB
Glycine hydrochloride (2:1)HMDB
Glycine phosphate (1:1)HMDB
Glycine, monopotasssium saltHMDB
Monopotasssium salt glycineHMDB
Monosodium salt glycineHMDB
Glycine carbonate (2:1), monolithium saltHMDB
Glycine carbonate (2:1), monosodium saltHMDB
Glycine hydrochlorideHMDB
Glycine, copper saltHMDB
Hydrochloride, glycineHMDB
Salt glycine, monoammoniumHMDB
Acid, aminoaceticHMDB
Cobalt salt glycineHMDB
Copper salt glycineHMDB
Glycine phosphateHMDB
Glycine, calcium saltHMDB
Glycine, calcium salt (2:1)HMDB
Glycine, cobalt saltHMDB
Phosphate, glycineHMDB
Salt glycine, monosodiumHMDB
Chemical FormulaC2H5NO2
Average Molecular Weight75.07
Monoisotopic Molecular Weight75.032
IUPAC Name2-aminoacetic acid
Traditional Nameglycine
CAS Registry Number56-40-6
SMILES
NCC(O)=O
InChI Identifier
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI KeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acids
Alternative Parents
Substituents
  • Alpha-amino acid
  • Amino acid
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organopnictogen compound
  • Primary aliphatic amine
  • Organic oxygen compound
  • Carbonyl group
  • Amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Biological role:

Industrial application:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point262.2 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility249 mg/mLNot Available
logP-3.21HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-3.3ALOGPS
logP-3.4ChemAxon
logS0.87ALOGPS
pKa (Strongest Acidic)2.31ChemAxon
pKa (Strongest Basic)9.24ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity16 m³·mol⁻¹ChemAxon
Polarizability6.65 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-001i-9000000000-222d6c3a1ba6afcd7ea9Spectrum
GC-MSGlycine, 3 TMS, GC-MS Spectrumsplash10-00dj-2900000000-0ef96bcf06ce475afcddSpectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-00dj-1900000000-1d289099ac79cfb8bb19Spectrum
GC-MSGlycine, 3 TMS, GC-MS Spectrumsplash10-00di-7910000000-6c972a683dfb75b69331Spectrum
GC-MSGlycine, 2 TMS, GC-MS Spectrumsplash10-0udi-0900000000-ef69e38ee6cebc2ece00Spectrum
GC-MSGlycine, 3 TMS, GC-MS Spectrumsplash10-00di-2910000000-3215b9e40f20c7b306cdSpectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-001i-9000000000-719b7f248956f13a312dSpectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-0udi-0900000000-99b4fc43740b21edc786Spectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-00di-1910000000-4cff4d14c73acff9442fSpectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-00dj-2900000000-0ef96bcf06ce475afcddSpectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-00dj-1900000000-1d289099ac79cfb8bb19Spectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-0002-4960000000-2c6fa028e985c6019854Spectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-00di-7910000000-6c972a683dfb75b69331Spectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-00di-2910000000-3215b9e40f20c7b306cdSpectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-0udi-0900000000-ef69e38ee6cebc2ece00Spectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-00ds-2900000000-ffffed9c78c16a884e4aSpectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-004r-3900000000-f288b50b7b6890429811Spectrum
GC-MSGlycine, non-derivatized, GC-MS Spectrumsplash10-0udi-1900000000-c76140c31c1f120e4b9dSpectrum
Predicted GC-MSGlycine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-001i-9000000000-f0a2cfbefb9fcd9b6c3eSpectrum
Predicted GC-MSGlycine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00di-9300000000-b8bbfc1276d5adb1ba04Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-00di-9000000000-6001578fc511ba3fefefSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-00di-9000000000-79b2a0a9d93de6a62358Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-00di-9000000000-9290dbe208c4744f4431Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-00di-9000000000-6001578fc511ba3fefefSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-00di-9000000000-79b2a0a9d93de6a62358Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-00di-9000000000-9290dbe208c4744f4431Spectrum
MS/MSLC-MS/MS Spectrum - , negativesplash10-00di-9000000000-605b44ac311a9af4bb7aSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-003r-9000000000-725357e461c898a7451eSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-9000000000-9f3930e66b117ad91dcaSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-001i-9000000000-b3336097dddbb5e22871Spectrum
MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-6M) , Positivesplash10-001i-9000000000-719b7f248956f13a312dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-004i-9000000000-342ab462db0835abb3d2Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-0ar1-9010000000-9daadc1d169a8530926dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-07y0-9220000000-8c7785f1f3aa8052679fSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-0ula-9110000000-43ada06fe1b56b4e9fccSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-017i-9000000000-fbd78fbb48f082235f42Spectrum
MS/MSLC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positivesplash10-004i-9000000000-c38d0fb28793438083a9Spectrum
MS/MSLC-MS/MS Spectrum - DI-ESI-Q-Exactive Plus , Positivesplash10-004i-9000000000-18a7ae48c7b0e15cdf18Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-004i-9000000000-342ab462db0835abb3d2Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0ar1-9010000000-9daadc1d169a8530926dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-07y0-9220000000-8c7785f1f3aa8052679fSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0ula-9110000000-43ada06fe1b56b4e9fccSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-017i-9000000000-fbd78fbb48f082235f42Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00di-9000000000-89b2c043a5afe3ebc6f6Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00di-9000000000-b4046e208ee8adb87021Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
5-aminolevulinate synthase, erythroid-specific, mitochondrialALAS2Xp11.21P22557 details
5-aminolevulinate synthase, nonspecific, mitochondrialALAS13p21.1P13196 details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialGCAT22q13.1O75600 details
Peroxisomal sarcosine oxidasePIPOX17q11.2Q9P0Z9 details
D-amino-acid oxidaseDAO12q24P14920 details
Trifunctional purine biosynthetic protein adenosine-3GART21q22.11P22102 details
Alanine--glyoxylate aminotransferase 2, mitochondrialAGXT25p13Q9BYV1 details
Glycine N-methyltransferaseGNMT6p12Q14749 details
Aminopeptidase NANPEPP15144 details
Glycine amidinotransferase, mitochondrialGATM15q21.1P50440 details
Bile acid-CoA:amino acid N-acyltransferaseBAAT9q22.3Q14032 details
Glycine--tRNA ligaseGARS7p15P41250 details
Aminomethyltransferase, mitochondrialAMT3p21.2-p21.1P48728 details
Serine--pyruvate aminotransferaseAGXT2q37.3P21549 details
Glutathione synthetaseGSS20q11.2P48637 details
Serine hydroxymethyltransferase, mitochondrialSHMT212q12-q14P34897 details
Sarcosine dehydrogenase, mitochondrialSARDH9q33-q34Q9UL12 details
Serine hydroxymethyltransferase, cytosolicSHMT117p11.2P34896 details
Glycine dehydrogenase [decarboxylating], mitochondrialGLDC9p22P23378 details
Cytosol aminopeptidaseLAP3P28838 details
Glycine cleavage system H protein, mitochondrialGCSHP23434 details
Vesicular inhibitory amino acid transporterSLC32A120q11.23Q9H598 details
Glycine N-acyltransferaseGLYAT11q12.1Q6IB77 details
Glycine N-acyltransferase-like protein 1GLYATL111q12.1Q969I3 details
Glycine N-acyltransferase-like protein 2GLYATL211q12.1Q8WU03 details
Kynurenine--oxoglutarate transaminase 3CCBL21p22.2Q6YP21 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Glutamate [NMDA] receptor subunit 3BGRIN3B19p13.3O60391 details
Glutamate [NMDA] receptor subunit epsilon-1GRIN2A16p13.2Q12879 details
Glutamate [NMDA] receptor subunit epsilon-3GRIN2C17q25Q14957 details
Sodium- and chloride-dependent glycine transporter 1SLC6A91p33P48067 details
Sodium- and chloride-dependent glycine transporter 2SLC6A511p15.1Q9Y345 details
Proton-coupled amino acid transporter 1SLC36A15q33.1Q7Z2H8 details
Monocarboxylate transporter 10SLC16A106q21-q22Q8TF71 details
Glycine receptor subunit alpha-1GLRA15q32P23415 details
Glycine receptor subunit alpha-2GLRA2P23416 details
Glycine receptor subunit alpha-3GLRA34q33-q34O75311 details
Glycine receptor subunit betaGLRB4q31.3P48167 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Trifunctional purine biosynthetic protein adenosine-3GART21q22.11P22102 details
Aminopeptidase NANPEPP15144 details
Cytosol aminopeptidaseLAP3P28838 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Aminopeptidase NANPEPP15144 details
Glutamate [NMDA] receptor subunit 3BGRIN3B19p13.3O60391 details
Glutamate [NMDA] receptor subunit epsilon-1GRIN2A16p13.2Q12879 details
Glutamate [NMDA] receptor subunit epsilon-3GRIN2C17q25Q14957 details
Glycine receptor subunit alpha-1GLRA15q32P23415 details
Glycine receptor subunit alpha-2GLRA2P23416 details
Glycine receptor subunit alpha-3GLRA34q33-q34O75311 details
Glycine receptor subunit betaGLRB4q31.3P48167 details
N-arachidonyl glycine receptorGPR1813q32Q14330 details
Transcriptional FactorsNot Available
Concentrations Data
Cannabis CultivarStatusValueReferenceDetails
Alien DawgDetected and Quantified1.82 mg/g dry wt
    • Jiamin Zheng, Yil...
details
GabriolaDetected and Quantified1.24 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Island HoneyDetected and Quantified0.693 mg/g dry wt
    • Jiamin Zheng, Yil...
details
QuadraDetected and Quantified2.35 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Sensi StarDetected and Quantified1.38 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Tangerine DreamDetected and Quantified1.13 mg/g dry wt
    • Jiamin Zheng, Yil...
details
HMDB IDHMDB0000123
DrugBank IDDB00145
Phenol Explorer Compound IDNot Available
FoodDB IDFDB000484
KNApSAcK IDC00001361
Chemspider ID730
KEGG Compound IDC00037
BioCyc IDGLY
BiGG ID33610
Wikipedia LinkGlycine
METLIN ID20
PubChem Compound750
PDB IDNot Available
ChEBI ID15428
References
General References
  1. Razak MA, Begum PS, Viswanath B, Rajagopal S: Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1. [PubMed:28337245 ]
  2. McCarty MF, DiNicolantonio JJ: The cardiometabolic benefits of glycine: Is glycine an 'antidote' to dietary fructose? Open Heart. 2014 May 28;1(1):e000103. doi: 10.1136/openhrt-2014-000103. eCollection 2014. [PubMed:25332814 ]
  3. Perez-Torres I, Zuniga-Munoz AM, Guarner-Lans V: Beneficial Effects of the Amino Acid Glycine. Mini Rev Med Chem. 2017;17(1):15-32. doi: 10.2174/1389557516666160609081602. [PubMed:27292783 ]

Only showing the first 10 proteins. There are 49 proteins in total.

Enzymes

General function:
Involved in 5-aminolevulinate synthase activity
Specific function:
Not Available
Gene Name:
ALAS2
Uniprot ID:
P22557
Molecular weight:
64632.86
General function:
Involved in 5-aminolevulinate synthase activity
Specific function:
Not Available
Gene Name:
ALAS1
Uniprot ID:
P13196
Molecular weight:
70580.325
General function:
Involved in glycine C-acetyltransferase activity
Specific function:
Not Available
Gene Name:
GCAT
Uniprot ID:
O75600
Molecular weight:
47973.79
General function:
Involved in oxidoreductase activity
Specific function:
Metabolizes sarcosine, L-pipecolic acid and L-proline.
Gene Name:
PIPOX
Uniprot ID:
Q9P0Z9
Molecular weight:
44065.515
General function:
Involved in D-amino-acid oxidase activity
Specific function:
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Gene Name:
DAO
Uniprot ID:
P14920
Molecular weight:
39473.75
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
GART
Uniprot ID:
P22102
Molecular weight:
107766.295
General function:
Involved in transaminase activity
Specific function:
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Gene Name:
AGXT2
Uniprot ID:
Q9BYV1
Molecular weight:
57155.905
General function:
Involved in folic acid binding
Specific function:
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Gene Name:
GNMT
Uniprot ID:
Q14749
Molecular weight:
32742.0
General function:
Involved in proteolysis
Specific function:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Gene Name:
ANPEP
Uniprot ID:
P15144
Molecular weight:
Not Available
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Name:
GATM
Uniprot ID:
P50440
Molecular weight:
48455.01

Transporters

General function:
Involved in ionotropic glutamate receptor activity
Specific function:
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:
GRIN3B
Uniprot ID:
O60391
Molecular weight:
112991.0
General function:
Involved in ionotropic glutamate receptor activity
Specific function:
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits
Gene Name:
GRIN2A
Uniprot ID:
Q12879
Molecular weight:
165281.2
General function:
Involved in ionotropic glutamate receptor activity
Specific function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:
GRIN2C
Uniprot ID:
Q14957
Molecular weight:
134531.1
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
Gene Name:
SLC6A9
Uniprot ID:
P48067
Molecular weight:
70582.02
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.
Gene Name:
SLC6A5
Uniprot ID:
Q9Y345
Molecular weight:
87433.13
General function:
Amino acid transport and metabolism
Specific function:
Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid
Gene Name:
SLC36A1
Uniprot ID:
Q7Z2H8
Molecular weight:
53075.0
General function:
Involved in transmembrane transport
Specific function:
Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:
SLC16A10
Uniprot ID:
Q8TF71
Molecular weight:
55492.1
General function:
Involved in ion transport
Specific function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:
GLRA1
Uniprot ID:
P23415
Molecular weight:
52623.4
General function:
Involved in ion transport
Specific function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:
GLRA2
Uniprot ID:
P23416
Molecular weight:
52001.6
General function:
Involved in ion transport
Specific function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:
GLRA3
Uniprot ID:
O75311
Molecular weight:
53799.8

Only showing the first 10 proteins. There are 49 proteins in total.