| Identification |
|---|
| HMDB Protein ID
| CDBP01922 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium- and chloride-dependent glycine transporter 1 |
| Description
| Not Available |
| Synonyms
|
- GlyT-1
- GlyT1
- Solute carrier family 6 member 9
|
| Gene Name
| SLC6A9 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in neurotransmitter:sodium symporter activity |
| Specific Function
| Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
|
| GO Classification
|
| Cellular Component |
| integral to plasma membrane |
| Component |
| integral to plasma membrane |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| organic acid:sodium symporter activity |
| sodium:amino acid symporter activity |
| transporter activity |
| organic acid transmembrane transporter activity |
| neurotransmitter transporter activity |
| neurotransmitter:sodium symporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| Molecular Function |
| neurotransmitter:sodium symporter activity |
| glycine:sodium symporter activity |
| Process |
| establishment of localization |
| transport |
| neurotransmitter transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p33 |
| SNPs
| SLC6A9 |
| Gene Sequence
|
>2121 bp
ATGAGCGGCGGAGACACGCGGGCTGCGATCGCTCGCCCCAGGATGGCCGCGGCTCATGGA
CCTGTGGCCCCCTCTTCCCCAGAACAGGTGACGCTTCTCCCTGTTCAGAGATCCTTCTTC
CTGCCACCCTTTTCTGGAGCCACTCCCTCTACTTCCCTAGCAGAGTCTGTCCTCAAAGTC
TGGCATGGGGCCTACAACTCTGGTCTCCTTCCCCAACTCATGGCCCAGCACTCCCTAGCC
ATGGCCCAGAATGGTGCTGTGCCCAGCGAGGCCACCAAGAGGGACCAGAACCTCAAACGG
GGCAACTGGGGCAACCAGATCGAGTTTGTACTGACGAGCGTGGGCTATGCCGTGGGCCTG
GGCAATGTCTGGCGCTTCCCATACCTCTGCTATCGCAACGGGGGAGGCGCCTTCATGTTC
CCCTACTTCATCATGCTCATCTTCTGCGGGATCCCCCTCTTCTTCATGGAGCTCTCCTTC
GGCCAGTTTGCAAGCCAGGGGTGCCTGGGGGTCTGGAGGATCAGCCCCATGTTCAAAGGA
GTGGGCTATGGTATGATGGTGGTGTCCACCTACATCGGCATCTACTACAATGTGGTCATC
TGCATCGCCTTCTACTACTTCTTCTCGTCCATGACGCACGTGCTGCCCTGGGCCTACTGC
AATAACCCCTGGAACACGCATGACTGCGCCGGTGTACTGGACGCCTCCAACCTCACCAAT
GGCTCTCGGCCAGCCGCCTTGCCCAGCAACCTCTCCCACCTGCTCAACCACAGCCTCCAG
AGGACCAGCCCCAGCGAGGAGTACTGGAGGCTGTACGTGCTGAAGCTGTCAGATGACATT
GGGAACTTTGGGGAGGTGCGGCTGCCCCTCCTTGGCTGCCTCGGTGTCTCCTGGTTGGTC
GTCTTCCTCTGCCTCATCCGAGGGGTCAAGTCTTCAGGGAAAGTGGTGTACTTCACGGCC
ACGTTCCCCTACGTGGTGCTGACCATTCTGTTTGTCCGCGGAGTGACCCTGGAGGGAGCC
TTTGACGGCATCATGTACTACCTAACCCCGCAGTGGGACAAGATCCTGGAGGCCAAGGTG
TGGGGTGATGCTGCCTCCCAGATCTTCTACTCACTGGGCTGCGCGTGGGGAGGCCTCATC
ACCATGGCTTCCTACAACAAGTTCCACAATAACTGTTACCGGGACAGTGTCATCATCAGC
ATCACCAACTGTGCCACCAGCGTCTATGCTGGCTTCGTCATCTTCTCCATCCTCGGCTTC
ATGGCCAATCACCTGGGCGTGGATGTGTCCCGTGTGGCAGACCACGGCCCTGGCCTGGCC
TTCGTGGCTTACCCCGAGGCCCTCACACTACTTCCCATCTCCCCGCTGTGGTCTCTGCTC
TTCTTCTTCATGCTTATCCTGCTGGGGCTGGGCACTCAGTTCTGCCTCCTGGAGACGCTG
GTCACAGCCATTGTGGATGAGGTGGGGAATGAGTGGATCCTGCAGAAAAAGACCTATGTG
ACCTTGGGCGTGGCTGTGGCTGGCTTCCTGCTGGGCATCCCCCTCACCAGCCAGGCAGGC
ATCTATTGGCTGCTGCTGATGGACAACTATGCGGCCAGCTTCTCCTTGGTGGTCATCTCC
TGCATCATGTGTGTGGCCATCATGTACATCTACGGGCACCGGAACTACTTCCAGGACATC
CAGATGATGCTGGGATTCCCACCACCCCTCTTCTTTCAGATCTGCTGGCGCTTCGTCTCT
CCCGCCATCATCTTCTTTATTCTAGTTTTCACTGTGATCCAGTACCAGCCGATCACCTAC
AACCACTACCAGTACCCAGGCTGGGCCGTGGCCATTGGCTTCCTCATGGCTCTGTCCTCC
GTCCTCTGCATCCCCCTCTACGCCATGTTCCGGCTCTGCCGCACAGACGGGGACACCCTC
CTCCAGCGTTTGAAAAATGCCACAAAGCCAAGCAGAGACTGGGGCCCTGCCCTCCTGGAG
CACCGGACAGGGCGCTACGCCCCCACCATAGCCCCCTCTCCTGAGGACGGCTTCGAGGTC
CAGCCACTGCACCCGGACAAGGCGCAGATCCCCATTGTGGGCAGTAATGGCTCCAGCCGC
CTCCAGGACTCCCGGATATGA
|
| Protein Properties |
|---|
| Number of Residues
| 706 |
| Molecular Weight
| 70582.02 |
| Theoretical pI
| 7.921 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sodium- and chloride-dependent glycine transporter 1
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
|
| External Links |
|---|
| GenBank ID Protein
| 67782315 |
| UniProtKB/Swiss-Prot ID
| P48067 |
| UniProtKB/Swiss-Prot Entry Name
| SC6A9_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_201649.2 |
| GeneCard ID
| SLC6A9 |
| GenAtlas ID
| SLC6A9 |
| HGNC ID
| HGNC:11056 |
| References |
|---|
| General References
| Not Available |