Cannabis Compound Database: Showing Compound Card for Cobalt (CDB005161)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (21)transporters (4) Show 39 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:15:28 UTC

Updated at

2020-12-07 19:11:42 UTC

CannabisDB ID

CDB005161

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Cobalt

Description

Cobalt, also known as cobalt(2+) ion or co(ii), belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. Cobalt is a weakly acidic compound (based on its pKa). Cobalt exists in all living organisms, ranging from bacteria to humans. Cobalt is a potentially toxic compound. Cobalt is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Co(II)	ChEBI
CO2+	ChEBI
Co(2+)	ChEBI
COBALT (II) ion	ChEBI
Cobalt(2+) ion	ChEBI
Cobalt(II) cation	ChEBI
Cobaltous ion	ChEBI
Cobalt(2+)	Kegg
Aquacat	HMDB
Co	HMDB
Cobalt-59	HMDB
Cobatope-57	HMDB
Kobalt	HMDB
Super cobalt	HMDB

Chemical Formula

Average Molecular Weight

58.93

Monoisotopic Molecular Weight

58.9332

IUPAC Name

lambda2-cobalt(2+) ion

Traditional Name

lambda2-cobalt(2+) ion

CAS Registry Number

7440-48-4

SMILES

[Co++]

InChI Identifier

InChI=1S/Co/q+2

InChI Key

XLJKHNWPARRRJB-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous transition metal compounds

Sub Class

Not Available

Direct Parent

Homogeneous transition metal compounds

Alternative Parents

Not Available

Substituents

Homogeneous transition metal

Molecular Framework

Not Available

External Descriptors

monoatomic dication (CHEBI:48828 )
divalent metal cation (CHEBI:48828 )
cobalt cation (CHEBI:48828 )
a cation (CO+2 )

Ontology

Physiological effect

Health effect:

Observation:

Liver damage

Health condition:

Multiple sclerosis

Gastrointestinal disorders:

Ingestion

Source:

Food

Environmental:

Tobacco smoke

Biological:

Animal

Plant:

Biological location:

Biofluid and excreta:

Organ and components:

Role

Environmental role:

Air pollutant

Biological role:

Trace element

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	1495 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.23	ChemAxon
pKa (Strongest Acidic)	3.09	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol⁻¹	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Not Available

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0a4i-9000000000-5ec55e9e276ff34b918f	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0a4i-9000000000-5ec55e9e276ff34b918f	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0a4i-9000000000-5ec55e9e276ff34b918f	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0a4i-9000000000-c4eed668d3af388c4a95	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0a4i-9000000000-c4eed668d3af388c4a95	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-9000000000-c4eed668d3af388c4a95	2016-08-03	View Spectrum

NMR

Not Available

Pathways

Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Methionine synthase	MTR	1q43	Q99707	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	ENPP2	8q24.1	Q13822	details
Methylmalonyl-CoA mutase, mitochondrial	MUT	6p12.3	P22033	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
Bis(5'-adenosyl)-triphosphatase	FHIT	3p14.2	P49789	details
cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	4q27	O76074	details
Chondroitin sulfate synthase 3	CHSY3	5q23.3	Q70JA7	details
Chondroitin sulfate synthase 2	CHPF	2q35	Q8IZ52	details
Chondroitin sulfate synthase 1	CHSY1	15q26.3	Q86X52	details
Glutamate carboxypeptidase 2	FOLH1	11p11.2	Q04609	details
D-2-hydroxyglutarate dehydrogenase, mitochondrial	D2HGDH	2q37.3	Q8N465	details
Membrane-bound transcription factor site-1 protease	MBTPS1	16\|16q24	Q14703	details
Mitochondrial intermediate peptidase	MIPEP	13q12	Q99797	details
Methionine aminopeptidase 1D, mitochondrial	MAP1D	2q31.1	Q6UB28	details
Methionine aminopeptidase 1	METAP1	4q23	P53582	details
Methionine aminopeptidase 2	METAP2	12q22	P50579	details
Carboxypeptidase M	CPM	12q14.3	P14384	details
Xaa-Pro aminopeptidase 1	XPNPEP1	10q25.3	Q9NQW7	details
Xaa-Pro aminopeptidase 2	XPNPEP2		O43895	details
Probable Xaa-Pro aminopeptidase 3	XPNPEP3	22q13.2	Q9NQH7	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Transcobalamin-2	TCN2	22q12.2	P20062	details
Transcobalamin-1	TCN1	11q11-q12	P20061	details
Gastric intrinsic factor	GIF	11q13	P27352	details
Cubilin	CUBN	10p12.31	O60494	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Methionine synthase	MTR	1q43	Q99707	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	ENPP2	8q24.1	Q13822	details
Methylmalonyl-CoA mutase, mitochondrial	MUT	6p12.3	P22033	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	4q27	O76074	details
Chondroitin sulfate synthase 3	CHSY3	5q23.3	Q70JA7	details
Chondroitin sulfate synthase 2	CHPF	2q35	Q8IZ52	details
Chondroitin sulfate synthase 1	CHSY1	15q26.3	Q86X52	details
Cubilin	CUBN	10p12.31	O60494	details
Carboxypeptidase M	CPM	12q14.3	P14384	details
Probable Xaa-Pro aminopeptidase 3	XPNPEP3	22q13.2	Q9NQH7	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	ENPP2	8q24.1	Q13822	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	ENPP2	8q24.1	Q13822	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000608

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB003581

KNApSAcK ID

Not Available

Chemspider ID

94546

KEGG Compound ID

C00175

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Cobalt

METLIN ID

Not Available

PubChem Compound

104729

PDB ID

Not Available

ChEBI ID

48828

References

General References

Not Available

Only showing the first 10 proteins. There are 39 proteins in total.

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Enzymes

Enzyme Details

1. Methionine synthase

General function:: Involved in cobalamin binding
Specific function:: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Gene Name:: MTR
Uniprot ID:: Q99707
Molecular weight:: 140525.91

Enzyme Details

2. Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

General function:: Involved in catalytic activity
Specific function:: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Gene Name:: ENPP2
Uniprot ID:: Q13822
Molecular weight:: 98992.78

Enzyme Details

3. Methylmalonyl-CoA mutase, mitochondrial

General function:: Involved in isomerase activity
Specific function:: Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.
Gene Name:: MUT
Uniprot ID:: P22033
Molecular weight:: 83133.755

Enzyme Details

4. S-adenosylmethionine synthase isoform type-2

General function:: Involved in methionine adenosyltransferase activity
Specific function:: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:: MAT2A
Uniprot ID:: P31153
Molecular weight:: 43660.37

Enzyme Details

5. S-adenosylmethionine synthase isoform type-1

General function:: Involved in methionine adenosyltransferase activity
Specific function:: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:: MAT1A
Uniprot ID:: Q00266
Molecular weight:: 43647.6

Enzyme Details

6. Bis(5'-adenosyl)-triphosphatase

General function:: Involved in catalytic activity
Specific function:: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.
Gene Name:: FHIT
Uniprot ID:: P49789
Molecular weight:: 16858.11

Enzyme Details

7. cGMP-specific 3',5'-cyclic phosphodiesterase

General function:: Involved in catalytic activity
Specific function:: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Gene Name:: PDE5A
Uniprot ID:: O76074
Molecular weight:: 99984.14

Enzyme Details

8. Chondroitin sulfate synthase 3

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.
Gene Name:: CHSY3
Uniprot ID:: Q70JA7
Molecular weight:: 100283.535

Enzyme Details

9. Chondroitin sulfate synthase 2

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer.
Gene Name:: CHPF
Uniprot ID:: Q8IZ52
Molecular weight:: 68367.94

Enzyme Details

10. Chondroitin sulfate synthase 1

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.
Gene Name:: CHSY1
Uniprot ID:: Q86X52
Molecular weight:: 91783.785

Transporters

Enzyme Details

1. Transcobalamin-2

General function:: Involved in cobalamin binding
Specific function:: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells
Gene Name:: TCN2
Uniprot ID:: P20062
Molecular weight:: 47534.5

Enzyme Details

2. Transcobalamin-1

General function:: Involved in cobalamin binding
Specific function:: Vitamin B12-binding protein. Transports cobalamin into cells
Gene Name:: TCN1
Uniprot ID:: P20061
Molecular weight:: 48206.3

Enzyme Details

3. Gastric intrinsic factor

General function:: Involved in cobalamin binding
Specific function:: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum by specific receptor-mediated endocytosis
Gene Name:: GIF
Uniprot ID:: P27352
Molecular weight:: 45415.7

Enzyme Details

4. Cubilin

General function:: Involved in calcium ion binding
Specific function:: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface
Gene Name:: CUBN
Uniprot ID:: O60494
Molecular weight:: 398672.8

Only showing the first 10 proteins. There are 39 proteins in total.

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Showing Compound Card for Cobalt (CDB005161)

Structure for CDB005161 (Cobalt)

Enzymes

Transporters