| Identification |
|---|
| HMDB Protein ID
| CDBP04066 |
| Secondary Accession Numbers
| Not Available |
| Name
| Xaa-Pro aminopeptidase 2 |
| Description
| Not Available |
| Synonyms
|
- Aminoacylproline aminopeptidase
- Membrane-bound APP
- Membrane-bound AmP
- Membrane-bound aminopeptidase P
- X-Pro aminopeptidase 2
- mAmP
|
| Gene Name
| XPNPEP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin |
| GO Classification
|
| Function |
| metalloexopeptidase activity |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| metallopeptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| XPNPEP2 |
| Gene Sequence
|
>2025 bp
ATGGCCCGGGCTCACTGGGGCTGCTGCCCCTGGCTGGTCCTCCTCTGTGCTTGTGCCTGG
GGCCACACAAAGCCAGTGGACCTTGGAGGGCAGGATGTGAGAAACTGTTCCACCAACCCC
CCTTACCTTCCAGTTACTGTGGTCAATACCACAATGTCACTCACAGCCCTCCGCCAGCAG
ATGCAGACCCAGAATCTCTCAGCCTACATCATCCCAGGCACAGATGCTCACATGAACGAG
TACATCGGCCAACATGACGAGAGGCGTGCGTGGATTACAGGCTTTACAGGGTCTGCAGGA
ACTGCAGTGGTGACTATGAAGAAAGCAGCTGTCTGGACCGACAGTCGCTACTGGACTCAG
GCTGAGCGGCAGATGGACTGCAACTGGGAGCTCCATAAGGAAGTTGGCACCACTCCTATT
GTCACCTGGCTCCTCACCGAGATTCCTGCTGGAGGGCGTGTGGGTTTTGACCCCTTCCTC
TTGTCCATTGACACCTGGGAGAGTTATGATCTGGCCCTCCAAGGCTCTAACAGACAGCTG
GTGTCCATCACAACCAATCTTGTGGACCTGGTATGGGGATCAGAGAGGCCACCGGTTCCA
AATCAACCCATTTATGCCCTGCAGGAGGCATTCACAGGGAGCACTTGGCAGGAGAAAGTA
TCTGGCGTCCGAAGCCAGATGCAGAAGCATCAAAAGGTCCCGACTGCCGTCCTTCTGTCG
GCGCTTGAGGAGACGGCCTGGCTCTTCAACCTTCGAGCCAGTGACATCCCCTATAACCCC
TTCTTCTATTCCTACACGCTGCTCACAGACTCTTCTATTAGGTTGTTTGCAAACAAGAGT
CGCTTTAGCTCCGAAACCTTGAGCTATCTGAACTCCAGTTGCACAGGCCCCATGTGTGTG
CAAATCGAGGATTACAGCCAAGTTCGTGACAGCATCCAGGCCTACTCATTGGGAGATGTG
AGGATCTGGATTGGGACCAGCTATACCATGTATGGGATCTATGAAATGATACCCAAGGAG
AAACTCGTGACAGACACCTACTCCCCAGTGATGATGACCAAGGCAGTGAAGAACAGCAAG
GAGCAGGCCCTCCTCAAGGCCAGCCACGTGCGGGACGCTGTGGCTGTGATCCGGTACTTG
GTCTGGCTGGAGAAGAACGTGCCCAAAGGCACAGTGGATGAGTTCTCGGGGGCAGAGATC
GTGGACAAGTTCCGAGGAGAAGAACAGTTCTCCTCCGGACCCAGTTTTGAAACCATCTCT
GCTAGTGGTCTGAATGCTGCCCTGGCCCACTACAGCCCGACCAAGGAGCTGAACCGCAAG
CTGTCCTCAGATGAGATGTACCTGCTGGACTCTGGGGGGCAGTACTGGGACGGGACCACA
GACATCACCAGAACAGTCCACTGGGGCACCCCCTCTGCCTTCCAGAAGGAGGCATACACC
CGTGTGCTGATAGGAAATATTGACCTGTCCAGGCTCATCTTTCCCGCTGCTACATCAGGG
CGAATGGTGGAGGCCTTTGCCCGCAGAGCCTTGTGGGATGCTGGTCTCAATTATGGTCAT
GGGACAGGCCACGGCATTGGCAACTTCCTGTGTGTGCATGAGTGGCCAGTGGGATTCCAG
TCCAACAACATCGCTATGGCCAAGGGCATGTTCACTTCCATTGAACCTGGTTACTATAAG
GATGGAGAATTTGGGATCCGTCTCGAAGATGTGGCTCTCGTGGTAGAAGCAAAGACCAAG
TACCCAGGGAGCTACCTGACCTTTGAAGTGGTATCATTTGTGCCCTATGACCGGAACCTC
ATCGATGTCAGCCTGCTGTCTCCCGAGCATCTCCAGTACCTGAATCGCTACTACCAGACC
ATCCGGGAGAAGGTGGGTCCAGAGCTGCAGAGGCGCCAGCTACTAGAGGAGTTCGAGTGG
CTTCAACAGCACACAGAGCCCCTGGCCGCCAGGGCCCCAGACACCGCCTCCTGGGCCTCT
GTGTTAGTGGTCTCCACCCTTGCCATCCTTGGCTGGAGTGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 674 |
| Molecular Weight
| 75624.2 |
| Theoretical pI
| 5.91 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Xaa-Pro aminopeptidase 2
MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQ
MQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQ
AERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQL
VSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLS
ALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCV
QIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSK
EQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETIS
ASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYT
RVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQ
SNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNL
IDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWAS
VLVVSTLAILGWSV
|
| External Links |
|---|
| GenBank ID Protein
| 11066157 |
| UniProtKB/Swiss-Prot ID
| O43895 |
| UniProtKB/Swiss-Prot Entry Name
| XPP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF195953 |
| GeneCard ID
| XPNPEP2 |
| GenAtlas ID
| XPNPEP2 |
| HGNC ID
| HGNC:12823 |
| References |
|---|
| General References
| Not Available |