| Identification |
|---|
| HMDB Protein ID
| CDBP03449 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carboxypeptidase M |
| Description
| Not Available |
| Synonyms
|
- CPM
|
| Gene Name
| CPM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carboxypeptidase activity |
| Specific Function
| Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins |
| GO Classification
|
| Function |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| transition metal ion binding |
| zinc ion binding |
| metallocarboxypeptidase activity |
| carboxypeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| exopeptidase activity |
| ion binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q14.3 |
| SNPs
| CPM |
| Gene Sequence
|
>1332 bp
ATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTC
AACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGT
TCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGTAGAAACCTGTGGGTTCTT
GTTGTGGGGCGGTTTCCAAAGGAACACAGAATTGGGATTCCAGAGTTCAAATACGTGGCA
AATATGCATGGAGATGAGACTGTTGGGCGGGAGCTGCTGCTCCATCTGATTGACTATCTC
GTAACCAGTGATGGCAAAGACCCTGAAATCACAAATCTGATCAATAGTACCCGGATACAC
ATCATGCCTTCCATGAACCCAGATGGATTTGAAGCCGTCAAAAAGCCTGACTGTTATTAC
AGCATCGGAAGGGAAAATTATAACCAGTATGACTTGAATCGAAATTTCCCCGATGCTTTT
GAATATAATAATGTCTCAAGGCAGCCTGAAACTGTGGCAGTCATGAAGTGGCTGAAAACA
GAGACGTTTGTCCTCTCTGCAAACCTCCATGGTGGTGCCCTCGTGGCCAGTTACCCATTT
GATAATGGTGTTCAAGCAACTGGGGCATTATACTCCCGAAGCTTAACGCCTGATGATGAT
GTTTTTCAATATCTTGCACATACCTATGCTTCAAGAAATCCCAACATGAAGAAAGGAGAC
GAGTGTAAAAACAAAATGAACTTTCCTAATGGTGTTACAAATGGATACTCTTGGTATCCA
CTCCAAGGTGGAATGCAAGATTACAACTACATCTGGGCCCAGTGTTTTGAAATTACGTTG
GAGCTGTCATGCTGTAAATATCCTCGTGAGGAGAAGCTTCCATCCTTTTGGAATAATAAC
AAAGCCTCATTAATTGAATATATAAAGCAGGTGCACCTAGGTGTAAAGGGTCAAGTTTTT
GATCAGAATGGAAATCCATTACCCAATGTAATTGTGGAAGTCCAAGACAGAAAACATATC
TGCCCCTATAGAACCAACAAATATGGAGAGTATTATCTCCTTCTCTTGCCTGGGTCCTAT
ATAATAAATGTTACAGTCCCTGGACATGATCCACACATCACAAAGGTGATTATTCCGGAG
AAATCCCAGAACTTCAGTGCTCTTAAAAAGGATATTCTACTTCCATTCCAAGGGCAATTG
GATTCTATCCCAGTATCAAATCCTTCATGCCCAATGATTCCTCTATACAGAAATTTGCCA
GACCACTCAGCTGCAACAAAGCCTAGTTTGTTCTTATTTTTAGTGAGTCTTTTGCACATA
TTCTTCAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 443 |
| Molecular Weight
| 50513.5 |
| Theoretical pI
| 7.4 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Carboxypeptidase M
MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL
VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH
IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT
ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD
ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN
KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY
IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP
DHSAATKPSLFLFLVSLLHIFFK
|
| External Links |
|---|
| GenBank ID Protein
| 12043756 |
| UniProtKB/Swiss-Prot ID
| P14384 |
| UniProtKB/Swiss-Prot Entry Name
| CBPM_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF262947 |
| GeneCard ID
| CPM |
| GenAtlas ID
| CPM |
| HGNC ID
| HGNC:2311 |
| References |
|---|
| General References
| Not Available |