Identification
HMDB Protein ID CDBP03447
Secondary Accession Numbers Not Available
Name Methionine aminopeptidase 1
Description Not Available
Synonyms
  1. MAP 1
  2. MetAP 1
  3. Peptidase M 1
Gene Name METAP1
Protein Type Enzyme
Biological Properties
General Function Involved in aminopeptidase activity
Specific Function Removes the amino-terminal methionine from nascent proteins. Required for normal progression through the cell cycle
GO Classification
Function
metalloexopeptidase activity
exopeptidase activity
aminopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
Process
proteolysis
metabolic process
macromolecule metabolic process
cellular process
protein metabolic process
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q23
SNPs METAP1
Gene Sequence
>1161 bp
ATGGCGGCCGTGGAGACGCGGGTGTGCGAGACAGACGGCTGCAGCAGTGAGGCCAAGCTC
CAGTGTCCCACTTGCATCAAGCTGGGCATCCAGGGCTCGTACTTCTGCTCGCAGGAATGT
TTTAAAGGAAGTTGGGCTACTCACAAGTTACTACATAAGAAAGCAAAAGATGAAAAGGCG
AAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTGACCCATGGGCAGGT
TATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCA
AGTTATATTCAAAGACCAGATTATGCTGATCATCCCTTAGGAATGTCTGAATCTGAACAG
GCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATATAGAAGGGATGCGA
CTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGT
GTAACTACTGAAGAAATAGATCACGCTGTACACTTAGCATGTATTGCAAGAAATTGCTAC
CCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCTCAGTGAATGAAGTC
ATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGAT
ATCACTCTTTATCGCAATGGTTATCATGGGGACCTGAATGAGACATTTTTTGTTGGAGAA
GTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCCTGATGCAAGCCATT
GATGCAGTGAAGCCTGGTGTTCGGTACAGAGAATTGGGAAACATTATCCAGAAGCATGCC
CAAGCAAATGGGTTTTCAGTTGTTCGAAGCTATTGTGGGCATGGAATCCACAAGCTTTTT
CATACAGCTCCCAATGTACCCCACTATGCTAAAAATAAAGCAGTTGGAGTGATGAAGTCG
GGCCATGTATTTACAATTGAGCCAATGATTTGTGAAGGCGGATGGCAGGATGAAACCTGG
CCAGATGGTTGGACTGCGGTGACAAGAGACGGAAAGCGGTCTGCTCAGTTTGAGCACACC
CTCCTGGTCACAGACACTGGCTGTGAAATCCTAACCCGGCGACTTGACAGTGCACGGCCT
CACTTCATGTCTCAATTTTAA
Protein Properties
Number of Residues 386
Molecular Weight 43214.9
Theoretical pI 7.18
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Methionine aminopeptidase 1
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
GenBank ID Protein 194385462
UniProtKB/Swiss-Prot ID P53582
UniProtKB/Swiss-Prot Entry Name AMPM1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK304239
GeneCard ID METAP1
GenAtlas ID METAP1
HGNC ID HGNC:15789
References
General References Not Available