Identification |
HMDB Protein ID
| CDBP03447 |
Secondary Accession Numbers
| Not Available |
Name
| Methionine aminopeptidase 1 |
Description
| Not Available |
Synonyms
|
- MAP 1
- MetAP 1
- Peptidase M 1
|
Gene Name
| METAP1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in aminopeptidase activity |
Specific Function
| Removes the amino-terminal methionine from nascent proteins. Required for normal progression through the cell cycle |
GO Classification
|
Function |
metalloexopeptidase activity |
exopeptidase activity |
aminopeptidase activity |
catalytic activity |
hydrolase activity |
peptidase activity |
peptidase activity, acting on l-amino acid peptides |
metallopeptidase activity |
Process |
proteolysis |
metabolic process |
macromolecule metabolic process |
cellular process |
protein metabolic process |
|
Cellular Location
|
- Cytoplasmic
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:4 |
Locus
| 4q23 |
SNPs
| METAP1 |
Gene Sequence
|
>1161 bp
ATGGCGGCCGTGGAGACGCGGGTGTGCGAGACAGACGGCTGCAGCAGTGAGGCCAAGCTC
CAGTGTCCCACTTGCATCAAGCTGGGCATCCAGGGCTCGTACTTCTGCTCGCAGGAATGT
TTTAAAGGAAGTTGGGCTACTCACAAGTTACTACATAAGAAAGCAAAAGATGAAAAGGCG
AAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTGACCCATGGGCAGGT
TATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCA
AGTTATATTCAAAGACCAGATTATGCTGATCATCCCTTAGGAATGTCTGAATCTGAACAG
GCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATATAGAAGGGATGCGA
CTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGT
GTAACTACTGAAGAAATAGATCACGCTGTACACTTAGCATGTATTGCAAGAAATTGCTAC
CCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCTCAGTGAATGAAGTC
ATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGAT
ATCACTCTTTATCGCAATGGTTATCATGGGGACCTGAATGAGACATTTTTTGTTGGAGAA
GTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCCTGATGCAAGCCATT
GATGCAGTGAAGCCTGGTGTTCGGTACAGAGAATTGGGAAACATTATCCAGAAGCATGCC
CAAGCAAATGGGTTTTCAGTTGTTCGAAGCTATTGTGGGCATGGAATCCACAAGCTTTTT
CATACAGCTCCCAATGTACCCCACTATGCTAAAAATAAAGCAGTTGGAGTGATGAAGTCG
GGCCATGTATTTACAATTGAGCCAATGATTTGTGAAGGCGGATGGCAGGATGAAACCTGG
CCAGATGGTTGGACTGCGGTGACAAGAGACGGAAAGCGGTCTGCTCAGTTTGAGCACACC
CTCCTGGTCACAGACACTGGCTGTGAAATCCTAACCCGGCGACTTGACAGTGCACGGCCT
CACTTCATGTCTCAATTTTAA
|
Protein Properties |
Number of Residues
| 386 |
Molecular Weight
| 43214.9 |
Theoretical pI
| 7.18 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Methionine aminopeptidase 1
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
|
External Links |
GenBank ID Protein
| 194385462 |
UniProtKB/Swiss-Prot ID
| P53582 |
UniProtKB/Swiss-Prot Entry Name
| AMPM1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK304239 |
GeneCard ID
| METAP1 |
GenAtlas ID
| METAP1 |
HGNC ID
| HGNC:15789 |
References |
General References
| Not Available |