Identification
HMDB Protein ID CDBP04065
Secondary Accession Numbers Not Available
Name Xaa-Pro aminopeptidase 1
Description Not Available
Synonyms
  1. Aminoacylproline aminopeptidase
  2. Cytosolic aminopeptidase P
  3. Soluble aminopeptidase P
  4. X-Pro aminopeptidase 1
  5. X-prolyl aminopeptidase 1, soluble
  6. sAmp
Gene Name XPNPEP1
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro
GO Classification
Function
metalloexopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
Process
metabolic process
macromolecule metabolic process
cellular process
protein metabolic process
proteolysis
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 10q25.3
SNPs XPNPEP1
Gene Sequence
>1872 bp
ATGCCTCCAAAGGTGACTTCAGAGCTGCTTCGGCAGCTGAGACAAGCCATGAGGAACTCT
GAGTATGTGACCGAACCGATCCAGGCCTACATCATCCCATCGGGAGATGCTCATCAGAGT
GAGTATATTGCTCCATGTGACTGTCGGCGGGCTTTTGTCTCTGGATTCGATGGCTCTGCG
GGCACAGCCATCATCACAGAAGAGCATGCAGCCATGTGGACTGACGGGCGCTACTTTCTC
CAGGCTGCCAAGCAAATGGACAGCAACTGGACACTTATGAAGATGGGTCTGAAGGACACA
CCAACTCAGGAAGACTGGCTGGTGAGTGTGCTTCCTGAAGGATCCAGGGTTGGTGTGGAC
CCCTTGATCATTCCTACAGATTATTGGAAGAAAATGGCCAAAGTTCTGAGAAGTGCCGGC
CATCACCTCATTCCTGTCAAGGAGAACCTCGTTGACAAAATCTGGACAGACCGTCCTGAG
CGCCCTTGCAAGCCTCTCCTCACACTGGGCCTGGATTACACAGGCATCTCCTGGAAGGAC
AAGGTTGCAGACCTTCGGTTGAAAATGGCTGAGAGGAACGTCATGTGGTTTGTGGTCACT
GCCTTGGATGAGATTGCGTGGCTATTTAATCTCCGAGGATCAGATGTGGAGCACAATCCA
GTATTTTTCTCCTACGCAATCATAGGACTAGAGACGATCATGCTCTTCATTGATGGTGAC
CGCATAGACGCCCCCAGTGTGAAGGAGCACCTGCTTCTTGACTTGGGTCTGGAAGCCGAA
TACAGGATCCAGGTGCATCCCTACAAGTCCATCCTGAGCGAGCTCAAGGCCCTGTGTGCT
GACCTCTCCCCAAGGGAGAAGGTGTGGGTCAGTGACAAGGCCAGCTATGCTGTGAGCGAG
ACCATCCCCAAGGACCACCGCTGCTGTATGCCTTACACCCCCATCTGCATCGCCAAAGCT
GTGAAGAATTCAGCTGAGTCAGAAGGCATGAGGCCGGCTCACATTAAAGATGCTGTTGCT
CTCTGTGAACTCTTTAACTGGCTGGAGAAAGAGGTTCCCAAAGGTGGTGTGACAGAGATC
TCAGCTGCTGACAAAGCTGAGGAGTTTCGCAGGCAACAGGCAGACTTTGTGGACCTGAGC
TTCCCAACAATTTCCAGTACGGGACCCAACGGCGCCATCATTCACTACGCGCCAGTCCCT
GAGACGAATAGGACCTTGTCCCTGGATGAGGTGTACCTTATTGACTCGGGTGCTCAATAC
AAGGATGGCACCACAGATGTGACGCGGACAATGCATTTTGGGACCCCTACAGCCTACGAG
AAGGAATGCTTCACATATGTCCTCAAGGGCCACATAGCTGTGAGTGCAGCCGTTTTCCCG
ACTGGAACCAAAGGTCACCTTCTTGACTCCTTTGCCCGTTCAGCTTTATGGGATTCAGGC
CTAGATTACTTGCACGGGACTGGACATGGTGTTGGGTCTTTTTTGAATGTCCATGAGGGT
CCTTGCGGCATCAGTTACAAAACATTCTCTGATGAGCCCTTGGAGGCAGGCATGATTGTC
ACTGATGAGCCCGGGTACTATGAAGATGGGGCTTTTGGAATTCGCATTGAGAATGTTGTC
CTTGTGGTTCCTGTGAAGACCAAGTATAATTTTAATAACCGGGGAAGCCTGACCTTTGAA
CCTCTAACATTGGTTCCAATTCAGACCAAAATGATAGATGTGGATTCTCTTACAGACAAA
GAGTGCGACTGGCTCAACAATTACCACCTGACCTGCAGGGATGTGATTGGGAAGGAATTG
CAGAAACAGGGCCGCCAGGAAGCTCTCGAGTGGCTCATCAGAGAGACGCAACCCATCTCC
AAACAGCATTAA
Protein Properties
Number of Residues 623
Molecular Weight 69917.2
Theoretical pI 5.41
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Xaa-Pro aminopeptidase 1
MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA
GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD
PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD
KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD
RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE
TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI
SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY
KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG
LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV
LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL
QKQGRQEALEWLIRETQPISKQH
GenBank ID Protein 9739017
UniProtKB/Swiss-Prot ID Q9NQW7
UniProtKB/Swiss-Prot Entry Name XPP1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF195530
GeneCard ID XPNPEP1
GenAtlas ID XPNPEP1
HGNC ID HGNC:12822
References
General References Not Available