Cannabis Compound Database: Showing Compound Card for Phosphoadenosine phosphosulfate (CDB005148)

Jump To Section:

Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (41) Show 48 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:14:10 UTC

Updated at

2020-11-18 16:39:26 UTC

CannabisDB ID

CDB005148

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Phosphoadenosine phosphosulfate

Description

Phosphoadenosine phosphosulfate, also known as 3'-phospho-5'-adenylyl sulfate or PAPS, belongs to the class of organic compounds known as purine ribonucleoside 3',5'-bisphosphates. These are purine ribobucleotides with one phosphate group attached to 3' and 5' hydroxyl groups of the ribose moiety. Phosphoadenosine phosphosulfate is a strong basic compound (based on its pKa). Phosphoadenosine phosphosulfate exists in all living species, ranging from bacteria to humans. Within humans, phosphoadenosine phosphosulfate participates in a number of enzymatic reactions. In particular, galactosylceramide (D18:1/18:0) and phosphoadenosine phosphosulfate can be converted into 3-O-sulfogalactosylceramide (D18:1/18:0) and adenosine 3',5'-diphosphate through its interaction with the enzyme galactosylceramide sulfotransferase. In addition, galabiosylceramide (D18:1/18:0) and phosphoadenosine phosphosulfate can be converted into adenosine 3',5'-diphosphate and galabiosylceramide sulfate (D18:1/18:0) through its interaction with the enzyme galactosylceramide sulfotransferase. An adenosine bisphosphate having monophosphate groups at the 3'- and 5'-positions and a sulfo group attached to the phosphate at position 5'. In humans, phosphoadenosine phosphosulfate is involved in globoid cell leukodystrophy. Phosphoadenosine phosphosulfate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
3'-Phosphoadenosine 5'-phosphosulfate	ChEBI
3'-Phosphoadenylyl sulfate	ChEBI
PAPS	ChEBI
3'-Phospho-5'-adenylyl sulfate	Kegg
3'-Phosphoadenosine 5'-phosphosulfuric acid	Generator
3'-Phosphoadenosine 5'-phosphosulphate	Generator
3'-Phosphoadenosine 5'-phosphosulphuric acid	Generator
3'-Phosphoadenylyl sulfuric acid	Generator
3'-Phosphoadenylyl sulphate	Generator
3'-Phosphoadenylyl sulphuric acid	Generator
3'-Phospho-5'-adenylyl sulfuric acid	Generator
3'-Phospho-5'-adenylyl sulphate	Generator
3'-Phospho-5'-adenylyl sulphuric acid	Generator
Phosphoadenosine phosphosulfuric acid	Generator
Phosphoadenosine phosphosulphate	Generator
Phosphoadenosine phosphosulphuric acid	Generator
3'-Phosphoadenosine-5'-phosphosulfate	HMDB
3'-Phosphoadenosine-5'-phosphosulphate	HMDB
3'-Phosphoadenylyl-sulfate	HMDB
3'-Phosphoadenylyl-sulphate	HMDB
5-Phosphoadenosine 3-phosphosulfate	HMDB
5-Phosphoadenosine 3-phosphosulphate	HMDB
Adenosine 3' phosphate 5' phosphosulfate	HMDB
Adenosine-3'-phosphate-5'-phosphosulfate	HMDB
Phosphosulfate, phosphoadenosine	HMDB
3’-Phosphoadenosine 5’-phosphosulfate	HMDB
3’-Phosphoadenosine 5’-phosphosulphate	HMDB
3’-Phosphoadenylyl sulfate	HMDB
3’-Phosphoadenylyl sulphate	HMDB
5'-Adenylyl sulfate 3'-phosphate	HMDB
5'-Adenylyl sulphate 3'-phosphate	HMDB
5’-Adenylyl sulfate 3’-phosphate	HMDB
5’-Adenylyl sulphate 3’-phosphate	HMDB
Adenosine 3'-phosphate 5'-phosphosulfate	HMDB
Adenosine 3'-phosphate 5'-phosphosulphate	HMDB
Adenosine 3'-phosphate 5'-sulfatophosphate	HMDB
Adenosine 3’-phosphate 5’-phosphosulfate	HMDB
Adenosine 3’-phosphate 5’-phosphosulphate	HMDB
Adenosine 3’-phosphate 5’-sulfatophosphate	HMDB
Adenosine 5'-phosphosulfate 3'-phosphate	HMDB
Adenosine 5'-phosphosulphate 3'-phosphate	HMDB
Adenosine 5’-phosphosulfate 3’-phosphate	HMDB
Adenosine 5’-phosphosulphate 3’-phosphate	HMDB

Chemical Formula

C₁₀H₁₅N₅O₁₃P₂S

Average Molecular Weight

507.26

Monoisotopic Molecular Weight

506.9862

IUPAC Name

[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]sulfonic acid

Traditional Name

3'-phosphoadenylyl sulfate

CAS Registry Number

482-67-7

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O

InChI Identifier

InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/t4-,6-,7-,10-/m1/s1

InChI Key

GACDQMDRPRGCTN-KQYNXXCUSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside 3',5'-bisphosphates. These are purine ribobucleotides with one phosphate group attached to 3' and 5' hydroxyl groups of the ribose moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside 3',5'-bisphosphates

Alternative Parents

Substituents

Purine ribonucleoside 3',5'-bisphosphate
Purine ribonucleoside monophosphate
Ribonucleoside 3'-phosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-aminopurine
Monosaccharide phosphate
Pentose monosaccharide
Imidazopyrimidine
Purine
Aminopyrimidine
Monoalkyl phosphate
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Phosphoric acid ester
Imidolactam
Alkyl phosphate
Pyrimidine
Tetrahydrofuran
Organic sulfuric acid or derivatives
Azole
Imidazole
Heteroaromatic compound
Secondary alcohol
Organoheterocyclic compound
Azacycle
Oxacycle
Organooxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Alcohol
Organic oxide
Organic oxygen compound
Primary amine
Amine
Organonitrogen compound
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

acyl sulfate (CHEBI:17980 )
adenosine bisphosphate (CHEBI:17980 )
purine ribonucleoside bisphosphate (CHEBI:17980 )
Coenzymes (C00053 )

Ontology

Disposition

Source:

Endogenous

Biological location:

Organ and components:

Cell and elements:

Element:

Platelet

Subcellular:

Golgi

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.65	ALOGPS
logP	-5.7	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	-2.4	ChemAxon
pKa (Strongest Basic)	3.94	ChemAxon
Physiological Charge	-4	ChemAxon
Hydrogen Acceptor Count	14	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	275.97 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	94.93 m³·mol⁻¹	ChemAxon
Polarizability	39.26 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Phosphoadenosine phosphosulfate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-8930200000-a2821e129c20bee87c33	Spectrum
Predicted GC-MS	Phosphoadenosine phosphosulfate, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9441110000-619798b0c3242743c13a	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-2901410000-afa8a71104e69c842868	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0900200000-8f9317ccb6340a4317c4	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-1900000000-e2c92e775605a11d728e	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0a7i-4900240000-500302d146b6d356a0b8	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0059-5900100000-07e0047589df3afabbbd	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9500000000-517ff9b08c8f8999b922	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0a4i-0000090000-ba006402f6f0af41d779	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-01ri-0402920000-7d549a97dd2276b8b754	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-01qi-0439100000-94b8e2004e4fb012c91d	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0900000000-63709bad7395f9f33acc	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-0900000000-94a8fdc8360cf2577ca6	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-003s-8900000000-0b1152e8f0b7373e9349	2021-09-25	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Sulfate/Sulfite Metabolism
Sulfite oxidase deficiency		Not Available
Sphingolipid Metabolism
Gaucher Disease		Not Available
Globoid Cell Leukodystrophy		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Carbohydrate sulfotransferase 11	CHST11	12q	Q9NPF2	details
Carbohydrate sulfotransferase 3	CHST3	10q22.1	Q7LGC8	details
Carbohydrate sulfotransferase 13	CHST13	3q21.3	Q8NET6	details
Carbohydrate sulfotransferase 12	CHST12	7p22	Q9NRB3	details
Galactosylceramide sulfotransferase	GAL3ST1	22q12.2	Q99999	details
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1	HS3ST3B1	17p12	Q9Y662	details
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	17p12	Q9Y663	details
Sulfotransferase 1A1	SULT1A1	16p12.1	P50225	details
3'(2'),5'-bisphosphate nucleotidase 1	BPNT1	1q41	O95861	details
Heparan sulfate glucosamine 3-O-sulfotransferase 1	HS3ST1	4p16	O14792	details
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	PAPSS1	4q24	O43252	details
Estrogen sulfotransferase	SULT1E1	4q13.1	P49888	details
Bile salt sulfotransferase	SULT2A1	19q13.3	Q06520	details
Carbohydrate sulfotransferase 1	CHST1	11p11.2	O43916	details
Heparan sulfate glucosamine 3-O-sulfotransferase 4	HS3ST4	16p11.2	Q9Y661	details
Sulfotransferase 1A2	SULT1A2	16p12.1	P50226	details
Heparan sulfate glucosamine 3-O-sulfotransferase 5	HS3ST5	6q21	Q8IZT8	details
Heparan sulfate glucosamine 3-O-sulfotransferase 2	HS3ST2	16p12	Q9Y278	details
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	PAPSS2	10q24	O95340	details
Protein-tyrosine sulfotransferase 2	TPST2	22q12.1	O60704	details
Sulfotransferase family cytosolic 2B member 1	SULT2B1	19q13.3	O00204	details
Sulfotransferase 1A3/1A4	SULT1A3	16p11.2	P50224	details
Carbohydrate sulfotransferase 7	CHST7	Xp11.23	Q9NS84	details
Carbohydrate sulfotransferase 14	CHST14	15q15.1	Q8NCH0	details
Heparan-sulfate 6-O-sulfotransferase 1	HS6ST1	2q21	O60243	details
Heparan-sulfate 6-O-sulfotransferase 2	HS6ST2	Xq26.2	Q96MM7	details
Adenosine 3'-phospho 5'-phosphosulfate transporter 1	SLC35B2	6p12.1-p11.2	Q8TB61	details
Heparan-sulfate 6-O-sulfotransferase 3	HS6ST3	13q32.1	Q8IZP7	details
Carbohydrate sulfotransferase 15	CHST15	10q26	Q7LFX5	details
Inositol monophosphatase 3	IMPAD1	8q12.1	Q9NX62	details
Tyrosylprotein sulfotransferase 1	TPST1	7q11.21	A4D2M0	details
Heparan sulfate glucosamine 3-O-sulfotransferase 6	HS3ST6		Q96QI5	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	5q33.1	P52848	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2	NDST2	10q22	P52849	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3	NDST3	4q26	O95803	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4	NDST4	4q26	Q9H3R1	details
Sulfotransferase 1C3	SULT1C3	2q12.3	Q6IMI6	details
Sulfotransferase 6B1	SULT6B1		Q6IMI4	details
Protein-tyrosine sulfotransferase 1	TPST1	7q11.21	O60507	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Inositol monophosphatase 3	IMPAD1	8q12.1	Q9NX62	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Carbohydrate sulfotransferase 11	CHST11	12q	Q9NPF2	details
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	5q33.1	P52848	details

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001134

DrugBank ID

DB02902

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

3'-Phosphoadenosine-5'-phosphosulfate

METLIN ID

6028

PubChem Compound

10214

PDB ID

Not Available

ChEBI ID

17980

References

General References

Not Available

Only showing the first 10 proteins. There are 48 proteins in total.

Show All

Enzymes

Enzyme Details

1. Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

General function:: Involved in catalytic activity
Specific function:: Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Gene Name:: ENPP1
Uniprot ID:: P22413
Molecular weight:: 104923.58

Enzyme Details

2. Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

General function:: Involved in catalytic activity
Specific function:: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity).
Gene Name:: ENPP3
Uniprot ID:: O14638
Molecular weight:: 100123.54

Enzyme Details

3. Carbohydrate sulfotransferase 11

General function:: Involved in sulfotransferase activity
Specific function:: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Gene Name:: CHST11
Uniprot ID:: Q9NPF2
Molecular weight:: 41002.97

Enzyme Details

4. Carbohydrate sulfotransferase 3

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.
Gene Name:: CHST3
Uniprot ID:: Q7LGC8
Molecular weight:: 54705.5

Enzyme Details

5. Carbohydrate sulfotransferase 13

General function:: Involved in sulfotransferase activity
Specific function:: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.
Gene Name:: CHST13
Uniprot ID:: Q8NET6
Molecular weight:: 38919.34

Enzyme Details

6. Carbohydrate sulfotransferase 12

General function:: Involved in sulfotransferase activity
Specific function:: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Gene Name:: CHST12
Uniprot ID:: Q9NRB3
Molecular weight:: 48413.945

Enzyme Details

7. Galactosylceramide sulfotransferase

General function:: Involved in galactosylceramide sulfotransferase activity
Specific function:: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).
Gene Name:: GAL3ST1
Uniprot ID:: Q99999
Molecular weight:: 48763.63

Enzyme Details

8. Heparan sulfate glucosamine 3-O-sulfotransferase 3B1

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Gene Name:: HS3ST3B1
Uniprot ID:: Q9Y662
Molecular weight:: 43323.605

Enzyme Details

9. Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Gene Name:: HS3ST3A1
Uniprot ID:: Q9Y663
Molecular weight:: 44899.155

Enzyme Details

10. Sulfotransferase 1A1

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Gene Name:: SULT1A1
Uniprot ID:: P50225
Molecular weight:: 34165.13

Only showing the first 10 proteins. There are 48 proteins in total.

Show All

Showing Compound Card for Phosphoadenosine phosphosulfate (CDB005148)

Structure for CDB005148 (Phosphoadenosine phosphosulfate)

Enzymes