Cannabis Compound Database: Showing Compound Card for 1-palmitoyl-2-linoleoyl-phosphatidylcholine (CDB001258)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (68)transporters (14) Show 121 proteins XML

Record Information

Version

1.0

Created at

2020-03-30 18:14:21 UTC

Updated at

2020-12-07 19:08:06 UTC

CannabisDB ID

CDB001258

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

1-palmitoyl-2-linoleoyl-phosphatidylcholine

Description

PC(16:0/18:2(9Z,12Z)) is a phosphatidylchloline (PC). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylcholines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PC(16:0/18:2(9Z,12Z)), in particular, consists of one hexadecanoyl chain to the C-1 atom, and one 9Z,12Z-octadecadienoyl to the C-2 atom. In E. coli, PCs can be found in the integral component of the cell outer membrane. They are hydrolyzed by Phospholipases to a 2-acylglycerophosphocholine and a carboxylate. This compound is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
1-Palmitoyl-2-linoleoyl-GPC	ChEBI
1-Palmitoyl-2-linoleoyl-GPC (16:0/18:2)	ChEBI
1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine	ChEBI
1-Palmitoyl-2-linoleoyl-sn-glycero-phosphatidylcholine	ChEBI
1-Palmitoyl-2-linoleoyl-sn-glycerophosphatidylcholine	ChEBI
1-Palmitoyl-2-linoleoylphosphatidylcholine	ChEBI
GPC(16:0/18:2)	ChEBI
GPCho 16:0/18:2(9Z,12Z)	ChEBI
GPCho(16:0/18:2(9Z,12Z))	ChEBI
GPCho(16:0/18:2)	ChEBI
GPCho(16:0/18:2omega6)	ChEBI
Lecithin	ChEBI
PC 16:0/18:2(9Z,12Z)	ChEBI
PC(16:0/18:2)	ChEBI
PC(16:0/18:2omega6)	ChEBI
PC(34:2)	ChEBI
Phosphatidylcholine 16:0/18:2(9Z,12Z)	ChEBI
Phosphatidylcholine(16:0/18:2(9Z,12Z))	ChEBI
Phosphatidylcholine(16:0/18:2)	ChEBI
Phosphatidylcholine(16:0/18:2omega6)	ChEBI
Gpcho(34:2)	HMDB
Phosphatidylcholine(34:2)	HMDB
2-Linoleoyl-1-palmitoyl-sn-phosphatidylcholine	HMDB
Palmitoyl-linoleoatephosphatidylcholine	HMDB
PLPC	HMDB
1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine	HMDB
1-Palmitoyl-2-linoleoyl-3-phosphatidylcholine	HMDB
1-Palmitoyl-2-linoleoyl-3-sn-glycerophosphatidylcholine	HMDB
1-Palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine	HMDB
1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine	HMDB
1-Palmitoyl-2-linoleoyllecithin	HMDB
GPC(16:0/18:2(9Z,12Z))	HMDB
GPC(16:0/18:2n6)	HMDB
GPC(16:0/18:2W6)	HMDB
GPC(34:2)	HMDB
GPCho(16:0/18:2n6)	HMDB
GPCho(16:0/18:2W6)	HMDB
L-alpha-1-Palmitoyl-2-linoleoylphosphatidylcholine	HMDB
L-Α-1-palmitoyl-2-linoleoylphosphatidylcholine	HMDB
PC(16:0/18:2n6)	HMDB
PC(16:0/18:2W6)	HMDB
Phosphatidylcholine(16:0/18:2n6)	HMDB
Phosphatidylcholine(16:0/18:2W6)	HMDB
PC(16:0/18:2(9Z,12Z))	Lipid Annotator, ChEBI

Chemical Formula

C₄₂H₈₀NO₈P

Average Molecular Weight

758.06

Monoisotopic Molecular Weight

757.5622

IUPAC Name

(2-{[(2R)-3-(hexadecanoyloxy)-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium

Traditional Name

(2-{[(2R)-3-(hexadecanoyloxy)-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium

CAS Registry Number

17708-90-6

SMILES

[H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC

InChI Identifier

InChI=1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChI Key

JLPULHDHAOZNQI-ZTIMHPMXSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phosphatidylcholines. These are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphocholines

Direct Parent

Phosphatidylcholines

Alternative Parents

Substituents

Diacylglycero-3-phosphocholine
Phosphocholine
Fatty acid ester
Dialkyl phosphate
Dicarboxylic acid or derivatives
Organic phosphoric acid derivative
Phosphoric acid ester
Alkyl phosphate
Fatty acyl
Quaternary ammonium salt
Tetraalkylammonium salt
Carboxylic acid ester
Carboxylic acid derivative
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Organooxygen compound
Organonitrogen compound
Organic oxide
Organopnictogen compound
Amine
Organic salt
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

phosphatidylcholine 34:2 (CHEBI:73002 )
Diacylglycerophosphocholines (LMGP01010594 )

Ontology

Physiological effect

Organoleptic effect:

Touch:

Smooth

Health effect:

Health condition:

Schizophrenia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Biological location:

Tissue and substructures:

Biofluid and excreta:

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Food and nutrition:

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.48	ALOGPS
logP	8.28	ChemAxon
logS	-7.5	ALOGPS
pKa (Strongest Acidic)	1.86	ChemAxon
pKa (Strongest Basic)	-6.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	111.19 Å²	ChemAxon
Rotatable Bond Count	40	ChemAxon
Refractivity	227.3 m³·mol⁻¹	ChemAxon
Polarizability	92.66 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	1-palmitoyl-2-linoleoyl-phosphatidylcholine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Orbitrap 30V, negative	splash10-0udl-0000000490-b7304b809294dbb2ea74	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 36V, negative	splash10-0006-0000000940-6acae25b185d1a864052	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 42V, negative	splash10-0006-0030000910-537e946aca08f069e72b	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 48V, negative	splash10-002f-0090000700-ecca901df00a9bff124c	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 54V, negative	splash10-004i-0090000200-fa34aef5028ed4787c4c	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 60V, negative	splash10-004i-0090000000-d9440bc0e6a9f6cdaf65	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 72V, negative	splash10-004i-0090000000-a5231d807bde53ae849a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 90V, negative	splash10-056r-0090000000-23038428933dc1fcc66d	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 109V, negative	splash10-056r-0090000000-ccce70356f7c7b18cbbf	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 133V, negative	splash10-056r-1090000000-32df8fc00b6e170aa02a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 157V, negative	splash10-004i-7190000000-811ed3f1fe9d51baf806	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 193V, negative	splash10-004i-9000000000-4bd8d3812cfdbafe42c7	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 53V, negative	splash10-0006-0000000900-aed1ee56f1886685cef5	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 22V, negative	splash10-0006-0000000900-f70fecaaa4c193d6952d	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 28V, negative	splash10-0006-0000000900-40ddf52a50eed646c5c3	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 34V, negative	splash10-0006-0000000900-79413b6bfab2c2699ebb	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 40V, negative	splash10-0006-0020000900-30d6507c6252bceda2ab	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 46V, negative	splash10-002f-0090000800-e35e5d8e6ef65358f1d7	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 53V, negative	splash10-004i-0090000200-d82c61ca09093ce2f75a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 59V, negative	splash10-004i-0090000000-a788f61f6153073cc513	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 71V, negative	splash10-056r-0090000000-5242b45696e3aa936e70	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 89V, negative	splash10-056r-0090000000-23038428933dc1fcc66d	2020-07-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0a4i-0000000900-73b8731f1bdde398585f	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0a59-0600000900-37c5a628d36a084e1386	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-003r-1900231200-522c9f77a95c208b08bc	2017-10-04	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylcholine Biosynthesis PC(16:0/18:2(9Z,12Z))		Not Available
Phosphatidylethanolamine Biosynthesis PE(16:0/18:2(9Z,12Z))		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Acyl-protein thioesterase 1	LYPLA1	8q11.23	O75608	details
Group XV phospholipase A2	PLA2G15		Q8NCC3	details
Calcium-dependent phospholipase A2	PLA2G5	1p36-p34	P39877	details
Group IIF secretory phospholipase A2	PLA2G2F	1p35	Q9BZM2	details
Cytosolic phospholipase A2	PLA2G4A	1q25	P47712	details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group XIIB secretory phospholipase A2-like protein	PLA2G12B		Q9BX93	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details
Group IIE secretory phospholipase A2	PLA2G2E	1p36.13	Q9NZK7	details
Acyl-protein thioesterase 2	LYPLA2	1p36.11	O95372	details
Group XIIA secretory phospholipase A2	PLA2G12A	4q25	Q9BZM1	details
85/88 kDa calcium-independent phospholipase A2	PLA2G6	22q13.1	O60733	details
Phosphatidylcholine-sterol acyltransferase	LCAT	16q22.1	P04180	details
Eosinophil lysophospholipase	CLC	19q13.1	Q05315	details
Phospholipase A2, membrane associated	PLA2G2A	1p35	P14555	details
Group IID secretory phospholipase A2	PLA2G2D	1p36.12	Q9UNK4	details
Phospholipase D2	PLD2	17p13.1	O14939	details
Phosphatidylethanolamine N-methyltransferase	PEMT	17p11.2	Q9UBM1	details
Phospholipase D1	PLD1	3q26	Q13393	details
Cytosolic phospholipase A2 gamma	PLA2G4C	19q13.3	Q9UP65	details
Group 3 secretory phospholipase A2	PLA2G3	22q12.2	Q9NZ20	details
D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	3q29	Q02338	details
Choline-phosphate cytidylyltransferase B	PCYT1B	Xp22.11	Q9Y5K3	details
Choline-phosphate cytidylyltransferase A	PCYT1A	3q29	P49585	details
Phosphatidylcholine:ceramide cholinephosphotransferase 2	SGMS2	4q25	Q8NHU3	details
Phosphatidylcholine:ceramide cholinephosphotransferase 1	SGMS1	10q11.2	Q86VZ5	details
Choline kinase alpha	CHKA	11q13.2	P35790	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Lecithin retinol acyltransferase	LRAT	4q32.1	O95237	details
Phospholipid scramblase 1	PLSCR1	3q23	O15162	details
Phosphatidylserine synthase 1	PTDSS1	8q22	P48651	details
Cholinephosphotransferase 1	CHPT1	12q	Q8WUD6	details
2-acylglycerol O-acyltransferase 2	MOGAT2	11q13.5	Q3SYC2	details
Choline/ethanolaminephosphotransferase 1	CEPT1	1p13.3	Q9Y6K0	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
Lysophospholipid acyltransferase 5	LPCAT3	12p13	Q6P1A2	details
Putative inactive group IIC secretory phospholipase A2	PLA2G2C	1p36.12	Q5R387	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Lysophosphatidylcholine acyltransferase 2	LPCAT2	16q12.2	Q7L5N7	details
Phospholipase D3	PLD3	19q13.2	Q8IV08	details
Phospholipase D4	PLD4	14q32.33	Q96BZ4	details
Phospholipid scramblase 2	PLSCR2	3q24	Q9NRY7	details
Phospholipid scramblase 3	PLSCR3	17p13.1	Q9NRY6	details
Phospholipid scramblase 4	PLSCR4	3q24	Q9NRQ2	details
Phospholipid scramblase family member 5	PLSCR5	3q24	A0PG75	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
Phospholipase B1, membrane-associated	PLB1	2p23.2	Q6P1J6	details
Phosphatidylethanolamine-binding protein 1	PEBP1	12q24.23	P30086	details
Phosphatidylethanolamine-binding protein 4	PEBP4	8p21.3	Q96S96	details
Cytosolic phospholipase A2 delta	PLA2G4D	15q15.1	Q86XP0	details
Cytosolic phospholipase A2 epsilon	PLA2G4E	15q15.1	Q3MJ16	details
Cytosolic phospholipase A2 zeta	PLA2G4F	15q15.1	Q68DD2	details
ADP-ribosylation factor GTPase-activating protein 1	ARFGAP1	20q13.33	Q8N6T3	details
Cytosolic phospholipase A2 beta	PLA2G4B	15q11.2-q21.3	P0C869	details
Phospholipase D1 variant			Q59EA4	details
Phospholipase D6	PLD6	17p11.2	Q8N2A8	details
Neuropathy target esterase	PNPLA6	19p13.2	Q8IY17	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Multidrug resistance protein 3	ABCB4	7q21.1	P21439	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Calcium-dependent phospholipase A2	PLA2G5	1p36-p34	P39877	details
Group IIF secretory phospholipase A2	PLA2G2F	1p35	Q9BZM2	details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group XIIB secretory phospholipase A2-like protein	PLA2G12B		Q9BX93	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details
Group IIE secretory phospholipase A2	PLA2G2E	1p36.13	Q9NZK7	details
Group XIIA secretory phospholipase A2	PLA2G12A	4q25	Q9BZM1	details
Phospholipase A2, membrane associated	PLA2G2A	1p35	P14555	details
Group IID secretory phospholipase A2	PLA2G2D	1p36.12	Q9UNK4	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Cholinephosphotransferase 1	CHPT1	12q	Q8WUD6	details
Choline/ethanolaminephosphotransferase 1	CEPT1	1p13.3	Q9Y6K0	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
Putative inactive group IIC secretory phospholipase A2	PLA2G2C	1p36.12	Q5R387	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Lysophosphatidylcholine acyltransferase 2	LPCAT2	16q12.2	Q7L5N7	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
Membrane-associated phosphatidylinositol transfer protein 1	PITPNM1	11q13	O00562	details
Membrane-associated phosphatidylinositol transfer protein 2	PITPNM2	12q24.31	Q9BZ72	details
Membrane-associated phosphatidylinositol transfer protein 3	PITPNM3	17p13	Q9BZ71	details
Cytosolic phospholipase A2 delta	PLA2G4D	15q15.1	Q86XP0	details
Cytosolic phospholipase A2 epsilon	PLA2G4E	15q15.1	Q3MJ16	details
Cytosolic phospholipase A2 zeta	PLA2G4F	15q15.1	Q68DD2	details
ADP-ribosylation factor GTPase-activating protein 1	ARFGAP1	20q13.33	Q8N6T3	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Phospholipase D2	PLD2	17p13.1	O14939	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0007973

DrugBank ID

DB02306

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB030253

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5287971

PDB ID

CPL

ChEBI ID

73002

References

General References

Not Available

Only showing the first 10 proteins. There are 121 proteins in total.

Show All

Enzymes

Enzyme Details

1. Acyl-protein thioesterase 1

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.
Gene Name:: LYPLA1
Uniprot ID:: O75608
Molecular weight:: 24669.355

Enzyme Details

2. Group XV phospholipase A2

General function:: Involved in phosphatidylcholine-sterol O-acyltransferase activity
Specific function:: Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
Gene Name:: PLA2G15
Uniprot ID:: Q8NCC3
Molecular weight:: Not Available

Enzyme Details

3. Calcium-dependent phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Gene Name:: PLA2G5
Uniprot ID:: P39877
Molecular weight:: 15674.065

Enzyme Details

4. Group IIF secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.
Gene Name:: PLA2G2F
Uniprot ID:: Q9BZM2
Molecular weight:: 23256.29

Enzyme Details

5. Cytosolic phospholipase A2

General function:: Involved in metabolic process
Specific function:: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Name:: PLA2G4A
Uniprot ID:: P47712
Molecular weight:: 85210.19

Enzyme Details

6. Phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Gene Name:: PLA2G1B
Uniprot ID:: P04054
Molecular weight:: 16359.535

Enzyme Details

7. Group XIIB secretory phospholipase A2-like protein

General function:: Involved in phospholipase A2 activity
Specific function:: Not known; does not seem to have catalytic activity.
Gene Name:: PLA2G12B
Uniprot ID:: Q9BX93
Molecular weight:: Not Available

Enzyme Details

8. Group 10 secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Gene Name:: PLA2G10
Uniprot ID:: O15496
Molecular weight:: 18153.04

Enzyme Details

9. Group IIE secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Gene Name:: PLA2G2E
Uniprot ID:: Q9NZK7
Molecular weight:: 15988.525

Enzyme Details

10. Acyl-protein thioesterase 2

General function:: Involved in hydrolase activity
Specific function:: May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.
Gene Name:: LYPLA2
Uniprot ID:: O95372
Molecular weight:: 24736.71

Transporters

Enzyme Details

1. Probable phospholipid-transporting ATPase IG

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11C
Uniprot ID:: Q8NB49
Molecular weight:: 129476.0

Enzyme Details

2. Probable phospholipid-transporting ATPase IH

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11A
Uniprot ID:: P98196
Molecular weight:: 129754.6

Enzyme Details

3. Probable phospholipid-transporting ATPase VA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10A
Uniprot ID:: O60312
Molecular weight:: 167686.6

Enzyme Details

4. Probable phospholipid-transporting ATPase IC

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both
Gene Name:: ATP8B1
Uniprot ID:: O43520
Molecular weight:: 143694.1

Enzyme Details

5. Probable phospholipid-transporting ATPase IIA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP9A
Uniprot ID:: O75110
Molecular weight:: 118581.5

Enzyme Details

6. Probable phospholipid-transporting ATPase VD

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10D
Uniprot ID:: Q9P241
Molecular weight:: 160272.3

Enzyme Details

7. Probable phospholipid-transporting ATPase IB

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8A2
Uniprot ID:: Q9NTI2
Molecular weight:: 129240.4

Enzyme Details

8. Probable phospholipid-transporting ATPase IA

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles
Gene Name:: ATP8A1
Uniprot ID:: Q9Y2Q0
Molecular weight:: 131368.2

Enzyme Details

9. Probable phospholipid-transporting ATPase IM

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8B4
Uniprot ID:: Q8TF62
Molecular weight:: 135867.0

Enzyme Details

10. Probable phospholipid-transporting ATPase IF

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11B
Uniprot ID:: Q9Y2G3
Molecular weight:: 134188.6

Only showing the first 10 proteins. There are 121 proteins in total.

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Showing Compound Card for 1-palmitoyl-2-linoleoyl-phosphatidylcholine (CDB001258)

Structure for CDB001258 (1-palmitoyl-2-linoleoyl-phosphatidylcholine)

Enzymes

Transporters