Cannabis Compound Database: Showing Protein Acyl-protein thioesterase 1 (CDBP00054)

Identification Biological properties Gene properties Protein properties External links References XML Show 19 compounds

Identification

HMDB Protein ID

CDBP00054

Secondary Accession Numbers

Not Available

Name

Acyl-protein thioesterase 1

Description

Not Available

Synonyms

APT-1
LPL-I
LysoPLA I
Lysophospholipase 1
Lysophospholipase I
hAPT1

Gene Name

LYPLA1

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.

GO Classification

Biological Process
small molecule metabolic process
fatty acid metabolic process
nitric oxide metabolic process
regulation of nitric-oxide synthase activity
Cellular Component
cytosol
mitochondrion
Function
catalytic activity
hydrolase activity
Molecular Function
lysophospholipase activity
palmitoyl-(protein) hydrolase activity

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phospholipid Biosynthesis
Glycerophospholipid metabolism	Not Available

Gene Properties

Chromosome Location

Locus

8q11.23

SNPs

LYPLA1

Gene Sequence

>693 bp
ATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCC
ACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGGCACGGATGGGCAGAAGCC
TTTGCAGGTATCAGAAGTTCACATATCAAATATATCTGCCCGCATGCGCCTGTTAGGCCT
GTTACATTAAATATGAACGTGGCTATGCCTTCATGGTTTGATATTATTGGGCTTTCACCA
GATTCACAGGAGGATGAATCTGGGATTAAACAGGCAGCAGAAAATATAAAAGCTTTGATT
GATCAAGAAGTGAAGAATGGCATTCCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAG
GGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACT
GCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCT
AATAGAGATATTTCTATTCTCCAGTGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATG
TTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTT
AAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAA
TTCATTGATAAACTCCTACCTCCAATTGATTGA

Protein Properties

Number of Residues

230

Molecular Weight

24669.355

Theoretical pI

6.771

Pfam Domain Function

Abhydrolase_2 (PF02230 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Acyl-protein thioesterase 1
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID

External Links

GenBank ID Protein

5453722

UniProtKB/Swiss-Prot ID

O75608

UniProtKB/Swiss-Prot Entry Name

LYPA1_HUMAN

PDB IDs