Cannabis Compound Database: Showing Compound Card for 1-18:2-2-18:3-phosphatidylcholine (CDB001256)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (68)transporters (14) Show 121 proteins XML

Record Information

Version

1.0

Created at

2020-03-30 18:14:13 UTC

Updated at

2020-12-07 19:08:06 UTC

CannabisDB ID

CDB001256

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

1-18:2-2-18:3-phosphatidylcholine

Description

PC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) is a phosphatidylchloline (PC). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylcholines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)), in particular, consists of one 9Z,12Z-octadecadienoyl chain to the C-1 atom, and one 9Z,12Z,15Z-octadecatrienoyl to the C-2 atom. In E. coli, PCs can be found in the integral component of the cell outer membrane. They are hydrolyzed by Phospholipases to a 2-acylglycerophosphocholine and a carboxylate. This compound is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
PC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))	Lipid Annotator
GPCho(36:5)	Lipid Annotator, HMDB
Phosphatidylcholine(18:2/18:3)	Lipid Annotator, HMDB
Phosphatidylcholine(36:5)	Lipid Annotator, HMDB
Lecithin	Lipid Annotator, HMDB
PC(18:2/18:3)	Lipid Annotator, HMDB
PC(36:5)	Lipid Annotator, HMDB
1-linoleoyl-2-a-linolenoyl-sn-glycero-3-phosphocholine	Lipid Annotator, HMDB
1-(9Z,12Z-octadecadienoyl)-2-(9Z,12Z,15Z-octadeatrienoyl)-sn-glycero-3-phosphocholine	Lipid Annotator, HMDB
GPCho(18:2/18:3)	Lipid Annotator, HMDB
1-Linoleoyl-2-alpha-linolenoyl-GPC	HMDB
1-Linoleoyl-2-alpha-linolenoyl-sn-glycero-3-phosphocholine	HMDB
1-Linoleoyl-2-alpha-linolenoyl-sn-glycero-phosphatidylcholine	HMDB
1-Linoleoyl-2-linolenoyl-GPC	HMDB
1-Linoleoyl-2-linolenoyl-sn-glycero-3-phosphocholine	HMDB
GPC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))	HMDB
GPC(18:2/18:3)	HMDB
GPC(18:2n6/18:3n3)	HMDB
GPC(18:2w6/18:3w3)	HMDB
GPC(36:5)	HMDB
GPCho(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))	HMDB
GPCho(18:2n6/18:3n3)	HMDB
GPCho(18:2w6/18:3w3)	HMDB
PC(18:2n6/18:3n3)	HMDB
PC(18:2w6/18:3w3)	HMDB
Phosphatidylcholine(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))	HMDB
Phosphatidylcholine(18:2n6/18:3n3)	HMDB
Phosphatidylcholine(18:2w6/18:3w3)	HMDB

Chemical Formula

C₄₄H₇₈NO₈P

Average Molecular Weight

780.07

Monoisotopic Molecular Weight

779.5465

IUPAC Name

trimethyl(2-{[(2R)-2-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyloxy]-3-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)azanium

Traditional Name

trimethyl(2-{[(2R)-2-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyloxy]-3-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)azanium

CAS Registry Number

85046-19-1

SMILES

[H][C@@](COC(=O)CCCCCCC\C=C/C\C=C/CCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/C\C=C/CC

InChI Identifier

InChI=1S/C44H78NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h9,11,14-17,20-23,42H,6-8,10,12-13,18-19,24-41H2,1-5H3/b11-9-,16-14-,17-15-,22-20-,23-21-/t42-/m1/s1

InChI Key

HZGAVPNEGHQJID-UNBCHYIMSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phosphatidylcholines. These are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphocholines

Direct Parent

Phosphatidylcholines

Alternative Parents

Substituents

Diacylglycero-3-phosphocholine
Phosphocholine
Fatty acid ester
Dialkyl phosphate
Dicarboxylic acid or derivatives
Organic phosphoric acid derivative
Phosphoric acid ester
Alkyl phosphate
Fatty acyl
Quaternary ammonium salt
Tetraalkylammonium salt
Carboxylic acid ester
Carboxylic acid derivative
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Organooxygen compound
Organonitrogen compound
Organic oxide
Organopnictogen compound
Amine
Organic salt
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Diacylglycerophosphocholines (LMGP01011626 )

Ontology

Physiological effect

Organoleptic effect:

Touch:

Smooth

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Biological location:

Tissue and substructures:

Biofluid and excreta:

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Food and nutrition:

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.53	ALOGPS
logP	8.08	ChemAxon
logS	-7.4	ALOGPS
pKa (Strongest Acidic)	1.86	ChemAxon
pKa (Strongest Basic)	-6.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	111.19 Å²	ChemAxon
Rotatable Bond Count	39	ChemAxon
Refractivity	239.85 m³·mol⁻¹	ChemAxon
Polarizability	92.51 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	1-18:2-2-18:3-phosphatidylcholine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0gwr-9051071400-929e4b1862586135e789	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03dr-5293051100-9ad1e887c0de7f76882f	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0079-9056041000-04425e55dcedcb5e99e4	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0090000300-7cbc12d8591ab0bca15f	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-0090001000-399fcaf8e372d24e45f5	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-3090100000-3651a4816138b70d8d1b	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-001i-0000000900-11abb7219d74a5a60a04	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001i-0600000900-8b887b2cddb30aa5f84a	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0ff0-1900050300-d7be45ffcd3d54601b68	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-0000000900-82395bc23558c5e73383	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0000000900-d73ebce581a3424e67e3	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0zi1-0200498400-fb911a077623a696d58f	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0000000900-6ac0ce44c5d362b404ab	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-0090020800-5f496e404553facd80f5	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-4290000000-681a1f38aee9b4fb151a	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-03di-0000000090-d1fecbe733b4fab2e6fb	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-03di-0030000090-d2e447c62bdff081e2d8	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-01t9-0090000040-a30e930ed397dcfebca4	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0000000090-be732a4aa7f691f68131	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0000000190-37d5d9b145362a874a18	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-014j-0900369110-afe8bff0cd7fe8179ea6	2021-09-24	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylcholine Biosynthesis PC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))		Not Available
Phosphatidylethanolamine Biosynthesis PE(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Acyl-protein thioesterase 1	LYPLA1	8q11.23	O75608	details
Group XV phospholipase A2	PLA2G15		Q8NCC3	details
Calcium-dependent phospholipase A2	PLA2G5	1p36-p34	P39877	details
Group IIF secretory phospholipase A2	PLA2G2F	1p35	Q9BZM2	details
Cytosolic phospholipase A2	PLA2G4A	1q25	P47712	details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group XIIB secretory phospholipase A2-like protein	PLA2G12B		Q9BX93	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details
Group IIE secretory phospholipase A2	PLA2G2E	1p36.13	Q9NZK7	details
Acyl-protein thioesterase 2	LYPLA2	1p36.11	O95372	details
Group XIIA secretory phospholipase A2	PLA2G12A	4q25	Q9BZM1	details
85/88 kDa calcium-independent phospholipase A2	PLA2G6	22q13.1	O60733	details
Phosphatidylcholine-sterol acyltransferase	LCAT	16q22.1	P04180	details
Eosinophil lysophospholipase	CLC	19q13.1	Q05315	details
Phospholipase A2, membrane associated	PLA2G2A	1p35	P14555	details
Group IID secretory phospholipase A2	PLA2G2D	1p36.12	Q9UNK4	details
Phospholipase D2	PLD2	17p13.1	O14939	details
Phosphatidylethanolamine N-methyltransferase	PEMT	17p11.2	Q9UBM1	details
Phospholipase D1	PLD1	3q26	Q13393	details
Cytosolic phospholipase A2 gamma	PLA2G4C	19q13.3	Q9UP65	details
Group 3 secretory phospholipase A2	PLA2G3	22q12.2	Q9NZ20	details
D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	3q29	Q02338	details
Choline-phosphate cytidylyltransferase B	PCYT1B	Xp22.11	Q9Y5K3	details
Choline-phosphate cytidylyltransferase A	PCYT1A	3q29	P49585	details
Phosphatidylcholine:ceramide cholinephosphotransferase 2	SGMS2	4q25	Q8NHU3	details
Phosphatidylcholine:ceramide cholinephosphotransferase 1	SGMS1	10q11.2	Q86VZ5	details
Choline kinase alpha	CHKA	11q13.2	P35790	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Lecithin retinol acyltransferase	LRAT	4q32.1	O95237	details
Phospholipid scramblase 1	PLSCR1	3q23	O15162	details
Phosphatidylserine synthase 1	PTDSS1	8q22	P48651	details
Cholinephosphotransferase 1	CHPT1	12q	Q8WUD6	details
2-acylglycerol O-acyltransferase 2	MOGAT2	11q13.5	Q3SYC2	details
Choline/ethanolaminephosphotransferase 1	CEPT1	1p13.3	Q9Y6K0	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
Lysophospholipid acyltransferase 5	LPCAT3	12p13	Q6P1A2	details
Putative inactive group IIC secretory phospholipase A2	PLA2G2C	1p36.12	Q5R387	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Lysophosphatidylcholine acyltransferase 2	LPCAT2	16q12.2	Q7L5N7	details
Phospholipase D3	PLD3	19q13.2	Q8IV08	details
Phospholipase D4	PLD4	14q32.33	Q96BZ4	details
Phospholipid scramblase 2	PLSCR2	3q24	Q9NRY7	details
Phospholipid scramblase 3	PLSCR3	17p13.1	Q9NRY6	details
Phospholipid scramblase 4	PLSCR4	3q24	Q9NRQ2	details
Phospholipid scramblase family member 5	PLSCR5	3q24	A0PG75	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
Phospholipase B1, membrane-associated	PLB1	2p23.2	Q6P1J6	details
Phosphatidylethanolamine-binding protein 1	PEBP1	12q24.23	P30086	details
Phosphatidylethanolamine-binding protein 4	PEBP4	8p21.3	Q96S96	details
Cytosolic phospholipase A2 delta	PLA2G4D	15q15.1	Q86XP0	details
Cytosolic phospholipase A2 epsilon	PLA2G4E	15q15.1	Q3MJ16	details
Cytosolic phospholipase A2 zeta	PLA2G4F	15q15.1	Q68DD2	details
ADP-ribosylation factor GTPase-activating protein 1	ARFGAP1	20q13.33	Q8N6T3	details
Cytosolic phospholipase A2 beta	PLA2G4B	15q11.2-q21.3	P0C869	details
Phospholipase D1 variant			Q59EA4	details
Phospholipase D6	PLD6	17p11.2	Q8N2A8	details
Neuropathy target esterase	PNPLA6	19p13.2	Q8IY17	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Multidrug resistance protein 3	ABCB4	7q21.1	P21439	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Calcium-dependent phospholipase A2	PLA2G5	1p36-p34	P39877	details
Group IIF secretory phospholipase A2	PLA2G2F	1p35	Q9BZM2	details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group XIIB secretory phospholipase A2-like protein	PLA2G12B		Q9BX93	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details
Group IIE secretory phospholipase A2	PLA2G2E	1p36.13	Q9NZK7	details
Group XIIA secretory phospholipase A2	PLA2G12A	4q25	Q9BZM1	details
Phospholipase A2, membrane associated	PLA2G2A	1p35	P14555	details
Group IID secretory phospholipase A2	PLA2G2D	1p36.12	Q9UNK4	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Cholinephosphotransferase 1	CHPT1	12q	Q8WUD6	details
Choline/ethanolaminephosphotransferase 1	CEPT1	1p13.3	Q9Y6K0	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
Putative inactive group IIC secretory phospholipase A2	PLA2G2C	1p36.12	Q5R387	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Lysophosphatidylcholine acyltransferase 2	LPCAT2	16q12.2	Q7L5N7	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
Membrane-associated phosphatidylinositol transfer protein 1	PITPNM1	11q13	O00562	details
Membrane-associated phosphatidylinositol transfer protein 2	PITPNM2	12q24.31	Q9BZ72	details
Membrane-associated phosphatidylinositol transfer protein 3	PITPNM3	17p13	Q9BZ71	details
Cytosolic phospholipase A2 delta	PLA2G4D	15q15.1	Q86XP0	details
Cytosolic phospholipase A2 epsilon	PLA2G4E	15q15.1	Q3MJ16	details
Cytosolic phospholipase A2 zeta	PLA2G4F	15q15.1	Q68DD2	details
ADP-ribosylation factor GTPase-activating protein 1	ARFGAP1	20q13.33	Q8N6T3	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Phospholipase D2	PLD2	17p13.1	O14939	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0008141

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB030226

KNApSAcK ID

Not Available

Chemspider ID

24766802

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

52922731

PDB ID

Not Available

ChEBI ID

Not Available

References

General References

Not Available

Only showing the first 10 proteins. There are 121 proteins in total.

Show All

Enzymes

Enzyme Details

1. Acyl-protein thioesterase 1

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.
Gene Name:: LYPLA1
Uniprot ID:: O75608
Molecular weight:: 24669.355

Enzyme Details

2. Group XV phospholipase A2

General function:: Involved in phosphatidylcholine-sterol O-acyltransferase activity
Specific function:: Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
Gene Name:: PLA2G15
Uniprot ID:: Q8NCC3
Molecular weight:: Not Available

Enzyme Details

3. Calcium-dependent phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Gene Name:: PLA2G5
Uniprot ID:: P39877
Molecular weight:: 15674.065

Enzyme Details

4. Group IIF secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.
Gene Name:: PLA2G2F
Uniprot ID:: Q9BZM2
Molecular weight:: 23256.29

Enzyme Details

5. Cytosolic phospholipase A2

General function:: Involved in metabolic process
Specific function:: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Name:: PLA2G4A
Uniprot ID:: P47712
Molecular weight:: 85210.19

Enzyme Details

6. Phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Gene Name:: PLA2G1B
Uniprot ID:: P04054
Molecular weight:: 16359.535

Enzyme Details

7. Group XIIB secretory phospholipase A2-like protein

General function:: Involved in phospholipase A2 activity
Specific function:: Not known; does not seem to have catalytic activity.
Gene Name:: PLA2G12B
Uniprot ID:: Q9BX93
Molecular weight:: Not Available

Enzyme Details

8. Group 10 secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Gene Name:: PLA2G10
Uniprot ID:: O15496
Molecular weight:: 18153.04

Enzyme Details

9. Group IIE secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Gene Name:: PLA2G2E
Uniprot ID:: Q9NZK7
Molecular weight:: 15988.525

Enzyme Details

10. Acyl-protein thioesterase 2

General function:: Involved in hydrolase activity
Specific function:: May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.
Gene Name:: LYPLA2
Uniprot ID:: O95372
Molecular weight:: 24736.71

Transporters

Enzyme Details

1. Probable phospholipid-transporting ATPase IG

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11C
Uniprot ID:: Q8NB49
Molecular weight:: 129476.0

Enzyme Details

2. Probable phospholipid-transporting ATPase IH

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11A
Uniprot ID:: P98196
Molecular weight:: 129754.6

Enzyme Details

3. Probable phospholipid-transporting ATPase VA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10A
Uniprot ID:: O60312
Molecular weight:: 167686.6

Enzyme Details

4. Probable phospholipid-transporting ATPase IC

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both
Gene Name:: ATP8B1
Uniprot ID:: O43520
Molecular weight:: 143694.1

Enzyme Details

5. Probable phospholipid-transporting ATPase IIA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP9A
Uniprot ID:: O75110
Molecular weight:: 118581.5

Enzyme Details

6. Probable phospholipid-transporting ATPase VD

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10D
Uniprot ID:: Q9P241
Molecular weight:: 160272.3

Enzyme Details

7. Probable phospholipid-transporting ATPase IB

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8A2
Uniprot ID:: Q9NTI2
Molecular weight:: 129240.4

Enzyme Details

8. Probable phospholipid-transporting ATPase IA

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles
Gene Name:: ATP8A1
Uniprot ID:: Q9Y2Q0
Molecular weight:: 131368.2

Enzyme Details

9. Probable phospholipid-transporting ATPase IM

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8B4
Uniprot ID:: Q8TF62
Molecular weight:: 135867.0

Enzyme Details

10. Probable phospholipid-transporting ATPase IF

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11B
Uniprot ID:: Q9Y2G3
Molecular weight:: 134188.6

Only showing the first 10 proteins. There are 121 proteins in total.

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Showing Compound Card for 1-18:2-2-18:3-phosphatidylcholine (CDB001256)

Structure for CDB001256 (1-18:2-2-18:3-phosphatidylcholine)

Enzymes

Transporters