Record Information
Version1.0
Created at2020-04-17 18:43:33 UTC
Updated at2020-12-07 19:11:06 UTC
CannabisDB IDCDB004853
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameL-Glutamine
DescriptionL-Glutamine, also known as levoglutamide or Q, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. An optically active form of glutamine having L-configuration. L-Glutamine is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. used to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age and older [fda label]. L-Glutamine is a very strong basic compound (based on its pKa). L-Glutamine exists in all living species, ranging from bacteria to humans. phenylacetyl-CoA and L-glutamine can be converted into phenylacetylglutamine; which is mediated by the enzyme glycine N-acyltransferase. In humans, L-glutamine is involved in phenylacetate metabolism. Outside of the human body, L-Glutamine is found, on average, in the highest concentration within a few different foods, such as wheats, broccoli, and red beetroots and in a lower concentration in cucumbers, garden onions, and nanking cherries. L-Glutamine has also been detected, but not quantified in, several different foods, such as rambutans, common salsifies, greenthread tea, common walnuts, and celery stalks. This could make L-glutamine a potential biomarker for the consumption of these foods. L-Glutamine is a potentially toxic compound. L-Glutamine, with regard to humans, has been found to be associated with several diseases such as schizophrenia, eosinophilic esophagitis, phosphoenolpyruvate carboxykinase deficiency 1, cytosolic, and crohn's disease; L-glutamine has also been linked to the inborn metabolic disorder fumarase deficiency. L-Glutamine is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
(2S)-2,5-Diamino-5-oxopentanoic acidChEBI
(2S)-2-Amino-4-carbamoylbutanoic acidChEBI
(S)-2,5-Diamino-5-oxopentanoic acidChEBI
Glutamic acid 5-amideChEBI
Glutamic acid amideChEBI
GLUTAMINEChEBI
L-(+)-GlutamineChEBI
L-2-Aminoglutaramic acidChEBI
L-Glutamic acid gamma-amideChEBI
L-GlutaminChEBI
L-Glutaminsaeure-5-amidChEBI
LevoglutamideChEBI
QChEBI
EndariKegg
NutrestoreKegg
(2S)-2,5-Diamino-5-oxopentanoateGenerator
(2S)-2-Amino-4-carbamoylbutanoateGenerator
(S)-2,5-Diamino-5-oxopentanoateGenerator
Glutamate 5-amideGenerator
Glutamate amideGenerator
L-2-AminoglutaramateGenerator
L-Glutamate g-amideGenerator
L-Glutamate gamma-amideGenerator
L-Glutamate γ-amideGenerator
L-Glutamic acid g-amideGenerator
L-Glutamic acid γ-amideGenerator
2-Aminoglutaramic acidHMDB
CebrogenHMDB
gamma-GlutamineHMDB
GlavaminHMDB
GluminHMDB
L-2-Aminoglutaramidic acidHMDB
L-Glutamic acid 5-amideHMDB
L-GlutamidHMDB
L-GlutamideHMDB
LevoglutamidHMDB
LevoglutamidaHMDB
LevoglutamidumHMDB
LevoglutaminaHMDB
PolyglutamineHMDB
StimulinaHMDB
D-GlutamineHMDB
D GlutamineHMDB
L GlutamineHMDB
Chemical FormulaC5H10N2O3
Average Molecular Weight146.14
Monoisotopic Molecular Weight146.0691
IUPAC Name(2S)-2-amino-4-carbamoylbutanoic acid
Traditional NameL-glutamine
CAS Registry Number56-85-9
SMILES
N[C@@H](CCC(N)=O)C(O)=O
InChI Identifier
InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChI KeyZDXPYRJPNDTMRX-VKHMYHEASA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentL-alpha-amino acids
Alternative Parents
Substituents
  • L-alpha-amino acid
  • Fatty acid
  • Amino acid
  • Carboximidic acid
  • Carboximidic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Amine
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Primary aliphatic amine
  • Organopnictogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point185 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility41.3 mg/mLYALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-3.64CHMELIK,J ET AL. (1991)
Predicted Properties
PropertyValueSource
logP-3.3ALOGPS
logP-4ChemAxon
logS-0.17ALOGPS
pKa (Strongest Acidic)2.15ChemAxon
pKa (Strongest Basic)9.31ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area106.41 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity33.11 m³·mol⁻¹ChemAxon
Polarizability13.87 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-001i-9000000000-bc4e294b8a3fd8c5abceSpectrum
GC-MSL-Glutamine, 3 TMS, GC-MS Spectrumsplash10-0a4i-0910000000-adb283bb40327f705680Spectrum
GC-MSL-Glutamine, 3 TMS, GC-MS Spectrumsplash10-0a4i-0910000000-134e80840320dadf6ad1Spectrum
GC-MSL-Glutamine, 3 TMS, GC-MS Spectrumsplash10-05fr-7910000000-89f87d4acc18299244f5Spectrum
GC-MSL-Glutamine, 2 TMS, GC-MS Spectrumsplash10-0a4i-0900000000-952a471cad5e5ead0a7eSpectrum
GC-MSL-Glutamine, 4 TMS, GC-MS Spectrumsplash10-004i-1961000000-94183211889cfe72d4ffSpectrum
GC-MSL-Glutamine, 3 TMS, GC-MS Spectrumsplash10-0a4i-1920000000-6505cd814f3707a0febaSpectrum
GC-MSL-Glutamine, 4 TMS, GC-MS Spectrumsplash10-004i-0692000000-9788416fdefb051b9586Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0a4i-0910000000-adb283bb40327f705680Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0a4i-0910000000-134e80840320dadf6ad1Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-00dj-4921200000-5446333d9aa592da8a07Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-05fr-7910000000-89f87d4acc18299244f5Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0a4i-0900000000-952a471cad5e5ead0a7eSpectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-004i-1961000000-94183211889cfe72d4ffSpectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0a4i-1920000000-6505cd814f3707a0febaSpectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-004i-0692000000-9788416fdefb051b9586Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0a4i-0910000000-ce2b15fe45c57a30c6bbSpectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0ab9-1900000000-7be5eab1056d2a249ab5Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0a4i-0900000000-5dc2d147bea250c7b80eSpectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-0fb9-0921000000-5dcbab01982f543f7925Spectrum
GC-MSL-Glutamine, non-derivatized, GC-MS Spectrumsplash10-004j-0940000000-102c9a43b5153f06927fSpectrum
Predicted GC-MSL-Glutamine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0006-9300000000-716b1947d48f42862cdfSpectrum
Predicted GC-MSL-Glutamine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00dl-9610000000-bfd7aa529a6e7f62de43Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0059-3900000000-c8f487d1a561e49327c0Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-9000000000-eee04836e7577e11d0d0Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0a59-9000000000-54ffbe5be8d7dbede389Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0002-0900000000-79283391c985f8286677Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-9000000000-6afbd5929b6e2371a371Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-0900000000-d5bd83614703b048228eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-0900000000-dc8def340a2655f9a399Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0002-0900000000-47e3e94a4387c53e0bd6Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-9000000000-c1acfa3750a90d81ce15Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-004i-0900000000-93f01bccbc98f18d4b07Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-0900000000-ce03708ec9ce55cd8952Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0933201000-9339494cebedd9c39135Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-004i-0900000000-64561a4c3590d5994e37Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0900000000-fdcdd7591fb182d804e2Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03dm-0030900000-66314ae704783630947aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0933100000-8798d2e46a415bb1029aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-004i-0900000000-dddea137e500a9b364ccSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0900000000-a78f8e4b2d6b37917b21Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0920000000-8c6e1eb7de6f70911080Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-0002-0900000000-fa42fc4bcba608992804Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-004i-2900000000-074610880ea19a417f60Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-059x-9200000000-8b7dae54eb8325667bd7Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-0006-9000000000-e115d9215eea3f0c3629Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-0006-9000000000-55b1ac62eea66274b984Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-001j-0900000000-c9c71895033d66cb2becSpectrum
NMR
TypeDescriptionView
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2GFPT25q34-q35O94808 details
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1GFPT12p13Q06210 details
AmidophosphoribosyltransferasePPAT4q12Q06203 details
Kynurenine--oxoglutarate transaminase 1CCBL19q34.11Q16773 details
Glutamine--tRNA ligaseQARS3p21.31P47897 details
Asparagine synthetase [glutamine-hydrolyzing]ASNS7q21.3P08243 details
GMP synthase [glutamine-hydrolyzing]GMPS3q24P49915 details
Protein-glutamine gamma-glutamyltransferase ETGM320q11.2Q08188 details
Protein-glutamine gamma-glutamyltransferase 2TGM220q12P21980 details
Glutamine synthetaseGLUL1q31P15104 details
Glutaminase liver isoform, mitochondrialGLS212q13Q9UI32 details
CTP synthase 1CTPS11p34.1P17812 details
Protein-glutamine gamma-glutamyltransferase 5TGM515q15.2O43548 details
Glutaminase kidney isoform, mitochondrialGLS2q32-q34O94925 details
Protein-glutamine gamma-glutamyltransferase 4TGM43p22-p21.33P49221 details
Protein-glutamine gamma-glutamyltransferase KTGM114q11.2P22735 details
Protein-glutamine gamma-glutamyltransferase 6TGM620p13O95932 details
Protein-glutamine gamma-glutamyltransferase ZTGM715q15.2Q96PF1 details
Phosphoribosylformylglycinamidine synthasePFAS17p13.1O15067 details
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrialPET1124q31.3O75879 details
Glutamine-dependent NAD(+) synthetaseNADSYN111q13.4Q6IA69 details
CTP synthase 2CTPS2Xp22Q9NRF8 details
Glycine N-acyltransferase-like protein 1GLYATL111q12.1Q969I3 details
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialQRSL16q21Q9H0R6 details
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrialGATC12q24.31O43716 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Neutral amino acid transporter B(0)SLC1A519q13.3Q15758 details
Large neutral amino acids transporter small subunit 2SLC7A814q11.2Q9UHI5 details
Sodium-coupled neutral amino acid transporter 3SLC38A33p21.3Q99624 details
Monocarboxylate transporter 10SLC16A106q21-q22Q8TF71 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
AmidophosphoribosyltransferasePPAT4q12Q06203 details
Protein-glutamine gamma-glutamyltransferase 2TGM220q12P21980 details
Coagulation factor XIII A chainF13A16p25.3-p24.3P00488 details
Protein-glutamine gamma-glutamyltransferase 5TGM515q15.2O43548 details
Protein-glutamine gamma-glutamyltransferase 4TGM43p22-p21.33P49221 details
Protein-glutamine gamma-glutamyltransferase KTGM114q11.2P22735 details
Protein-glutamine gamma-glutamyltransferase 6TGM620p13O95932 details
Protein-glutamine gamma-glutamyltransferase ZTGM715q15.2Q96PF1 details
CAD proteinCAD2p22-p21P27708 details
ReceptorsNot Available
Transcriptional FactorsNot Available
Concentrations Data
Cannabis CultivarStatusValueReferenceDetails
Alien DawgDetected and Quantified14.8 mg/g dry wt
    • Jiamin Zheng, Yil...
details
GabriolaDetected and Quantified33.3 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Island HoneyDetected and Quantified29.5 mg/g dry wt
    • Jiamin Zheng, Yil...
details
QuadraDetected and Quantified4.32 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Sensi StarDetected and Quantified15.3 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Tangerine DreamDetected and Quantified36.6 mg/g dry wt
    • Jiamin Zheng, Yil...
details
HMDB IDHMDB0000641
DrugBank IDDB00130
Phenol Explorer Compound IDNot Available
FoodDB IDFDB030965
KNApSAcK IDC00001359
Chemspider ID5746
KEGG Compound IDC00064
BioCyc IDGLN
BiGG ID33714
Wikipedia LinkGlutamine
METLIN ID5614
PubChem Compound5961
PDB IDNot Available
ChEBI ID18050
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 38 proteins in total.

Enzymes

General function:
Involved in metabolic process
Specific function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Gene Name:
GFPT2
Uniprot ID:
O94808
Molecular weight:
76929.885
General function:
Involved in metabolic process
Specific function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Gene Name:
GFPT1
Uniprot ID:
Q06210
Molecular weight:
78805.81
General function:
Involved in amidophosphoribosyltransferase activity
Specific function:
Not Available
Gene Name:
PPAT
Uniprot ID:
Q06203
Molecular weight:
57398.52
General function:
Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Gene Name:
CCBL1
Uniprot ID:
Q16773
Molecular weight:
47874.765
General function:
Involved in nucleotide binding
Specific function:
Not Available
Gene Name:
QARS
Uniprot ID:
P47897
Molecular weight:
87797.97
General function:
Involved in asparagine synthase (glutamine-hydrolyzing) activity
Specific function:
Not Available
Gene Name:
ASNS
Uniprot ID:
P08243
Molecular weight:
62167.855
General function:
Involved in catalytic activity
Specific function:
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
Gene Name:
GMPS
Uniprot ID:
P49915
Molecular weight:
76714.79
General function:
Involved in protein-glutamine gamma-glutamyltransferase activity
Specific function:
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
Gene Name:
TGM3
Uniprot ID:
Q08188
Molecular weight:
76631.26
General function:
Involved in protein-glutamine gamma-glutamyltransferase activity
Specific function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Gene Name:
TGM2
Uniprot ID:
P21980
Molecular weight:
77328.21
General function:
Involved in glutamate-ammonia ligase activity
Specific function:
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
Gene Name:
GLUL
Uniprot ID:
P15104
Molecular weight:
42064.15

Transporters

General function:
Involved in sodium:dicarboxylate symporter activity
Specific function:
Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses
Gene Name:
SLC1A5
Uniprot ID:
Q15758
Molecular weight:
56597.6
General function:
Involved in transport
Specific function:
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney
Gene Name:
SLC7A8
Uniprot ID:
Q9UHI5
Molecular weight:
58381.1
General function:
Amino acid transport and metabolism
Specific function:
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission
Gene Name:
SLC38A3
Uniprot ID:
Q99624
Molecular weight:
55772.4
General function:
Involved in transmembrane transport
Specific function:
Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:
SLC16A10
Uniprot ID:
Q8TF71
Molecular weight:
55492.1

Only showing the first 10 proteins. There are 38 proteins in total.