| Identification |
|---|
| HMDB Protein ID
| CDBP00645 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-glutamine gamma-glutamyltransferase 4 |
| Description
| Not Available |
| Synonyms
|
- Fibrinoligase
- Prostate transglutaminase
- Prostate-specific transglutaminase
- TG(P)
- TGP
- TGase P
- TGase-4
- Transglutaminase P
- Transglutaminase-4
|
| Gene Name
| TGM4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein-glutamine gamma-glutamyltransferase activity |
| Specific Function
| Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
|
| GO Classification
|
| Biological Process |
| peptide cross-linking |
| protein polyamination |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring amino-acyl groups |
| protein-glutamine gamma-glutamyltransferase activity |
| Molecular Function |
| metal ion binding |
| protein-glutamine gamma-glutamyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| post-translational protein modification |
| peptide cross-linking |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p22-p21.33 |
| SNPs
| TGM4 |
| Gene Sequence
|
>2055 bp
ATGATGGATGCATCAAAAGAGCTGCAAGTTCTCCACATTGACTTCTTGAATCAGGACAAC
GCCGTTTCTCACCACACATGGGAGTTCCAAACGAGCAGTCCTGTGTTCCGGCGAGGACAG
GTGTTTCACCTGCGGCTGGTGCTGAACCAGCCCCTACAATCCTACCACCAACTGAAACTG
GAATTCAGCACAGGGCCGAATCCTAGCATCGCCAAACACACCCTGGTGGTGCTCGACCCG
AGGACGCCCTCAGACCACTACAACTGGCAGGCAACCCTTCAAAATGAGTCTGGCAAAGAG
GTCACAGTGGCTGTCACCAGTTCCCCCAATGCCATCCTGGGCAAGTACCAACTAAACGTG
AAAACTGGAAACCACATCCTTAAGTCTGAAGAAAACATCCTATACCTTCTCTTCAACCCA
TGGTGTAAAGAGGACATGGTTTTCATGCCTGATGAGGACGAGCGCAAAGAGTACATCCTC
AATGACACGGGCTGCCATTACGTGGGGGCTGCCAGAAGTATCAAATGCAAACCCTGGAAC
TTTGGTCAGTTTGAGAAAAATGTCCTGGACTGCTGCATTTCCCTGCTGACTGAGAGCTCC
CTCAAGCCCACAGATAGGAGGGACCCCGTGCTGGTGTGCAGGGCCATGTGTGCTATGATG
AGCTTTGAGAAAGGCCAGGGCGTGCTCATTGGGAATTGGACTGGGGACTACGAAGGTGGC
ACAGCCCCATACAAGTGGACAGGCAGTGCCCCGATCCTGCAGCAGTACTACAACACGAAG
CAGGCTGTGTGCTTTGGCCAGTGCTGGGTGTTTGCTGGGATCCTGACTACAGTGCTGAGA
GCGTTGGGCATCCCAGCACGCAGTGTGACAGGCTTCGATTCAGCTCACGACACAGAAAGG
AACCTCACGGTGGACACCTATGTGAATGAGAATGGCGAGAAAATCACCAGTATGACCCAC
GACTCTGTCTGGAATTTCCATGTGTGGACGGATGCCTGGATGAAGCGACCGGATCTGCCC
AAGGGCTACGACGGCTGGCAGGCTGTGGACGCAACGCCGCAGGAGCGAAGCCAGGGTGTC
TTCTGCTGTGGGCCATCACCACTGACCGCCATCCGCAAAGGTGACATCTTTATTGTCTAT
GACACCAGATTCGTCTTCTCAGAAGTGAATGGTGACAGGCTCATCTGGTTGGTGAAGATG
GTGAATGGGCAGGAGGAGTTACACGTAATTTCAATGGAGACCACAAGCATCGGGAAAAAC
ATCAGCACCAAGGCAGTGGGCCAAGACAGGCGGAGAGATATCACCTATGAGTACAAGTAT
CCAGAAGGCTCCTCTGAGGAGAGGCAGGTCATGGATCATGCCTTCCTCCTTCTCAGTTCT
GAGAGGGAGCACAGACGACCTGTAAAAGAGAACTTTCTTCACATGTCGGTACAATCAGAT
GATGTGCTGCTGGGAAACTCTGTTAATTTCACCGTGATTCTTAAAAGGAAGACCGCTGCC
CTACAGAATGTCAACATCTTGGGCTCCTTTGAACTACAGTTGTACACTGGCAAGAAGATG
GCAAAACTGTGTGACCTCAATAAGACCTCGCAGATCCAAGGTCAAGTATCAGAAGTGACT
CTGACCTTGGACTCCAAGACCTACATCAACAGCCTGGCTATATTAGATGATGAGCCAGTT
ATCAGAGGTTTCATCATTGCGGAAATTGTGGAGTCTAAGGAAATCATGGCCTCTGAAGTA
TTCACGTCTTTCCAGTACCCTGAGTTCTCTATAGAGTTGCCTAACACAGGCAGAATTGGC
CAGCTACTTGTCTGCAATTGTATCTTCAAGAATACCCTGGCCATCCCTTTGACTGACGTC
AAGTTCTCTTTGGAAAGCCTGGGCATCTCCTCACTACAGACCTCTGACCATGGGACGGTG
CAGCCTGGTGAGACCATCCAATCCCAAATAAAATGCACCCCAATAAAAACTGGACCCAAG
AAATTTATCGTCAAGTTAAGTTCCAAACAAGTGAAAGAGATTAATGCTCAGAAGATTGTT
CTCATCACCAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 684 |
| Molecular Weight
| 77144.595 |
| Theoretical pI
| 6.76 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein-glutamine gamma-glutamyltransferase 4
MMDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVLNQPLQSYHQLKL
EFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNV
KTGNHILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWN
FGQFEKNVLDCCISLLTESSLKPTDRRDPVLVCRAMCAMMSFEKGQGVLIGNWTGDYEGG
TAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILTTVLRALGIPARSVTGFDSAHDTER
NLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQERSQGV
FCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMETTSIGKN
ISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREHRRPVKENFLHMSVQSD
DVLLGNSVNFTVILKRKTAALQNVNILGSFELQLYTGKKMAKLCDLNKTSQIQGQVSEVT
LTLDSKTYINSLAILDDEPVIRGFIIAEIVESKEIMASEVFTSFQYPEFSIELPNTGRIG
QLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQTSDHGTVQPGETIQSQIKCTPIKTGPK
KFIVKLSSKQVKEINAQKIVLITK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P49221 |
| UniProtKB/Swiss-Prot Entry Name
| TGM4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L34840 |
| GeneCard ID
| TGM4 |
| GenAtlas ID
| TGM4 |
| HGNC ID
| HGNC:11780 |
| References |
|---|
| General References
| Not Available |