Cannabis Compound Database: Showing Compound Card for L-Cysteine (CDB004848)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (22)transporters (3) Show 37 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:43:02 UTC

Updated at

2020-12-07 19:11:06 UTC

CannabisDB ID

CDB004848

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Cysteine

Description

L-Cysteine, also known as C or e 920, belongs to the class of organic compounds known as cysteine and derivatives. Cysteine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. L-Cysteine is a drug which is used for the prevention of liver damage and kidney damage associated with overdoses of acetaminophen. L-Cysteine is a very strong basic compound (based on its pKa). L-Cysteine exists in all living species, ranging from bacteria to humans. Within humans, L-cysteine participates in a number of enzymatic reactions. In particular, L-cysteine can be converted into 3-sulfinoalanine; which is mediated by the enzyme cysteine dioxygenase type 1. In addition, L-cysteine can be converted into hydrogen sulfide and pyruvic acid through the action of the enzyme cystathionine gamma-lyase. In humans, L-cysteine is involved in cysteine metabolism. L-Cysteine is a sulfury tasting compound. Outside of the human body, L-Cysteine is found, on average, in the highest concentration within a few different foods, such as sunflowers, soy beans, and watermelons and in a lower concentration in common wheats, dates, and beers. L-Cysteine has also been detected, but not quantified in, several different foods, such as oyster mushrooms, salmonberries, rapes, safflowers, and cupuaçus. This could make L-cysteine a potential biomarker for the consumption of these foods. L-Cysteine is a potentially toxic compound. An optically active form of cysteine having L-configuration. L-Cysteine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2R)-2-Amino-3-mercaptopropanoic acid	ChEBI
(2R)-2-Amino-3-sulfanylpropanoic acid	ChEBI
(R)-2-Amino-3-mercaptopropanoic acid	ChEBI
C	ChEBI
Cys	ChEBI
CYSTEINE	ChEBI
e 920	ChEBI
e-920	ChEBI
e920	ChEBI
FREE cysteine	ChEBI
L-2-Amino-3-mercaptopropionic acid	ChEBI
L-Cystein	ChEBI
L-Zystein	ChEBI
Ecolan	Kegg
(2R)-2-Amino-3-mercaptopropanoate	Generator
(2R)-2-Amino-3-sulfanylpropanoate	Generator
(2R)-2-Amino-3-sulphanylpropanoate	Generator
(2R)-2-Amino-3-sulphanylpropanoic acid	Generator
(R)-2-Amino-3-mercaptopropanoate	Generator
L-2-Amino-3-mercaptopropionate	Generator
(+)-2-Amino-3-mercaptopropionic acid	HMDB
(R)-(+)-Cysteine	HMDB
(R)-2-Amino-3-mercapto-propanoate	HMDB
(R)-2-Amino-3-mercapto-propanoic acid	HMDB
(R)-Cysteine	HMDB
2-Amino-3-mercaptopropanoate	HMDB
2-Amino-3-mercaptopropanoic acid	HMDB
2-Amino-3-mercaptopropionate	HMDB
2-Amino-3-mercaptopropionic acid	HMDB
3-Mercapto-L-alanine	HMDB
Acetylcysteine	HMDB
alpha-Amino-beta-thiolpropionic acid	HMDB
b-Mercaptoalanine	HMDB
beta-Mercaptoalanine	HMDB
Carbocysteine	HMDB
Cisteina	HMDB
Cisteinum	HMDB
Cystein	HMDB
Cysteinum	HMDB
Half-cystine	HMDB
L Cysteine	HMDB
L-(+)-Cysteine	HMDB
L-2-Amino-3-mercaptopropanoate	HMDB
L-2-Amino-3-mercaptopropanoic acid	HMDB
Polycysteine	HMDB
Thioserine	HMDB
Cysteine hydrochloride	HMDB
Zinc cysteinate	HMDB
Half cystine	HMDB

Chemical Formula

C₃H₇NO₂S

Average Molecular Weight

121.16

Monoisotopic Molecular Weight

121.0197

IUPAC Name

(2R)-2-amino-3-sulfanylpropanoic acid

Traditional Name

L-cysteine

CAS Registry Number

52-90-4

SMILES

N[C@@H](CS)C(O)=O

InChI Identifier

InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1

InChI Key

XUJNEKJLAYXESH-REOHCLBHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cysteine and derivatives. Cysteine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Cysteine and derivatives

Alternative Parents

Substituents

Cysteine or derivatives
Alpha-amino acid
L-alpha-amino acid
Amino acid
Alkylthiol
Carboxylic acid
Monocarboxylic acid or derivatives
Organic oxygen compound
Primary amine
Organosulfur compound
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Primary aliphatic amine
Carbonyl group
Amine
Hydrocarbon derivative
Organopnictogen compound
Organic oxide
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:17561 )
L-alpha-amino acid (CHEBI:17561 )
cysteine (CHEBI:17561 )
serine family amino acid (CHEBI:17561 )
Common amino acids (C00097 )

Ontology

Dermal

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	220 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	277 mg/mL at 25 °C	BEILSTEIN
logP	-2.49	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-2.6	ALOGPS
logP	-2.8	ChemAxon
logS	-0.72	ALOGPS
pKa (Strongest Acidic)	2.35	ChemAxon
pKa (Strongest Basic)	9.05	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	28.22 m³·mol⁻¹	ChemAxon
Polarizability	11.41 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Cysteine, 4 TMS, GC-MS Spectrum	splash10-00kb-0950000000-df7e91c95b610ff21c79	Spectrum
GC-MS	L-Cysteine, 4 TMS, GC-MS Spectrum	splash10-00kb-0940000000-aefe34765fb447090a23	Spectrum
GC-MS	L-Cysteine, 4 TMS, GC-MS Spectrum	splash10-00kb-0970000000-10a155c40ea499023052	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-00kb-0940000000-037a3a34651c3154b3b3	Spectrum
GC-MS	L-Cysteine, 4 TMS, GC-MS Spectrum	splash10-00di-9850000000-118c43e33861a6baa8d2	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-014j-0690100000-0aeb88fd507505e6b718	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-00kb-0950000000-df7e91c95b610ff21c79	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-00kb-0940000000-aefe34765fb447090a23	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-00kb-0970000000-10a155c40ea499023052	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-00kb-0940000000-037a3a34651c3154b3b3	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-0uk9-5619100000-8cb2558373966174ced3	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-00di-9850000000-118c43e33861a6baa8d2	Spectrum
GC-MS	L-Cysteine, non-derivatized, GC-MS Spectrum	splash10-0gi0-0960000000-03b2097de6f9637d29cb	Spectrum
Predicted GC-MS	L-Cysteine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004l-9100000000-4553906a941a5e87ec97	Spectrum
Predicted GC-MS	L-Cysteine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004i-9200000000-cfaf705cd0452d428454	Spectrum
Predicted GC-MS	L-Cysteine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Cysteine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Cysteine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Cysteine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Cysteine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Cysteine, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-00b9-9600000000-374c5872d68662832769	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0a4i-9000000000-ddbd3df6b8dbb280ffba	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0a4i-9000000000-320a2c77443b80ebf733	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0089-0900000000-9dcd3d757c5cd11eb18e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-3900000000-212e081fe83ad70de0ad	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-2eb01f41c225f614db24	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-a19834eb7cb9f211fdf2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-2458f2587761e779ed93	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-77e590f0ed26f69b31c0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-3900000000-7b1857997392b006b95f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-3900000000-bc268c27ed5706a4bbd2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-00di-0900000000-4573390bccc238e3c91b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-0udi-3900000000-212e081fe83ad70de0ad	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-0udi-3900000000-7b1857997392b006b95f	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - QqQ 14V, negative	splash10-001i-9000000000-5dc69d3b59bd15290aef	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-0a6r-9100000000-ed3c9c47ed98679090ab	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 0V, Positive	splash10-00di-2900000000-8bb219d17ccdf7ac0a5d	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Positive	splash10-0a4i-9000000000-e623d5a27b5075c82b4d	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-056r-9100000000-4e26cc13af7c878115f7	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00b9-9600000000-4352a7b437c34c04d9f0	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-004i-9200000000-7b4cd034c717561c61dd	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-052f-9000000000-8f351cbca6ffed356a9b	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-6900000000-51ba0df80cc33423420b	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0079-9400000000-4aa2b707c391d5838d29	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-001i-9000000000-95c7672c7836c0fc51c9	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glutathione Metabolism
Glycine and Serine Metabolism
Methionine Metabolism
Taurine and Hypotaurine Metabolism
Cysteine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aspartate aminotransferase, cytoplasmic	GOT1	10q24.1-q25.1	P17174	details
Aspartate aminotransferase, mitochondrial	GOT2	16q21	P00505	details
Aminopeptidase N	ANPEP		P15144	details
Glutamate--cysteine ligase catalytic subunit	GCLC	6p12	P48506	details
Glutamate--cysteine ligase regulatory subunit	GCLM	1p22.1	P48507	details
Cystathionine gamma-lyase	CTH	1p31.1	P32929	details
Glutaminyl-peptide cyclotransferase	QPCT	2p22.2	Q16769	details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details
Glutathione synthetase	GSS	20q11.2	P48637	details
Cytosol aminopeptidase	LAP3		P28838	details
Cysteine sulfinic acid decarboxylase	CSAD	12q13.11-q14.3	Q9Y600	details
Cysteine dioxygenase type 1	CDO1	5q23.2	Q16878	details
Methylated-DNA--protein-cysteine methyltransferase	MGMT	10q26	P16455	details
Cysteine desulfurase, mitochondrial	NFS1	20q11.22	Q9Y697	details
Phosphopantothenate--cysteine ligase	PPCS	1p34.2	Q9HAB8	details
Thiamine transporter 2	SLC19A3	2q37	Q9BZV2	details
Probable cysteine--tRNA ligase, mitochondrial	CARS2	13q34	Q9HA77	details
Prenylcysteine oxidase 1	PCYOX1	2p13.3	Q9UHG3	details
Molybdenum cofactor sulfurase	MOCOS	18q12	Q96EN8	details
Cysteine--tRNA ligase, cytoplasmic	CARS	11p15.5	P49589	details
Gamma-glutamylcyclotransferase	GGCT	7p15-p14	O75223	details
Cysteine dioxygenase	CDO-1		Q16857	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Large neutral amino acids transporter small subunit 2	SLC7A8	14q11.2	Q9UHI5	details
Thiamine transporter 2	SLC19A3	2q37	Q9BZV2	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aminopeptidase N	ANPEP		P15144	details
Glutaminyl-peptide cyclotransferase	QPCT	2p22.2	Q16769	details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details
Cytosol aminopeptidase	LAP3		P28838	details
Cysteine dioxygenase type 1	CDO1	5q23.2	Q16878	details
Probable cysteine--tRNA ligase, mitochondrial	CARS2	13q34	Q9HA77	details
Molybdenum cofactor sulfurase	MOCOS	18q12	Q96EN8	details
Cysteine--tRNA ligase, cytoplasmic	CARS	11p15.5	P49589	details
Cysteine dioxygenase	CDO-1		Q16857	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aminopeptidase N	ANPEP		P15144	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Glutamate--cysteine ligase catalytic subunit	GCLC	6p12	P48506	details
Cystathionine gamma-lyase	CTH	1p31.1	P32929	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000574

DrugBank ID

DB00151

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

17561

References

General References

Not Available

Only showing the first 10 proteins. There are 37 proteins in total.

Show All

Enzymes

Enzyme Details

1. Aspartate aminotransferase, cytoplasmic

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Plays a key role in amino acid metabolism (By similarity).
Gene Name:: GOT1
Uniprot ID:: P17174
Molecular weight:: 46247.14

Enzyme Details

2. Aspartate aminotransferase, mitochondrial

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:: GOT2
Uniprot ID:: P00505
Molecular weight:: 47517.285

Enzyme Details

3. Aminopeptidase N

General function:: Involved in proteolysis
Specific function:: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Gene Name:: ANPEP
Uniprot ID:: P15144
Molecular weight:: Not Available

Enzyme Details

4. Glutamate--cysteine ligase catalytic subunit

General function:: Involved in glutamate-cysteine ligase activity
Specific function:: Not Available
Gene Name:: GCLC
Uniprot ID:: P48506
Molecular weight:: 68629.42

Enzyme Details

5. Glutamate--cysteine ligase regulatory subunit

General function:: Involved in oxidoreductase activity
Specific function:: Not Available
Gene Name:: GCLM
Uniprot ID:: P48507
Molecular weight:: 30726.7

Enzyme Details

6. Cystathionine gamma-lyase

General function:: Involved in pyridoxal phosphate binding
Specific function:: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.
Gene Name:: CTH
Uniprot ID:: P32929
Molecular weight:: 41259.91

Enzyme Details

7. Glutaminyl-peptide cyclotransferase

General function:: Involved in peptidase activity
Specific function:: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Gene Name:: QPCT
Uniprot ID:: Q16769
Molecular weight:: 40876.14

Enzyme Details

8. Cystathionine beta-synthase

General function:: Involved in cysteine biosynthetic process from serine
Specific function:: Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).
Gene Name:: CBS
Uniprot ID:: P35520
Molecular weight:: 60586.05

Enzyme Details

9. Glutathione synthetase

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: GSS
Uniprot ID:: P48637
Molecular weight:: 52384.325

Enzyme Details

10. Cytosol aminopeptidase

General function:: Involved in aminopeptidase activity
Specific function:: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Gene Name:: LAP3
Uniprot ID:: P28838
Molecular weight:: Not Available

Transporters

Enzyme Details

1. Large neutral amino acids transporter small subunit 2

General function:: Involved in transport
Specific function:: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney
Gene Name:: SLC7A8
Uniprot ID:: Q9UHI5
Molecular weight:: 58381.1

Enzyme Details

2. Thiamine transporter 2

General function:: Involved in folic acid binding
Specific function:: Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity.
Gene Name:: SLC19A3
Uniprot ID:: Q9BZV2
Molecular weight:: 55664.265

Enzyme Details

3. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 37 proteins in total.

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Showing Compound Card for L-Cysteine (CDB004848)

Structure for CDB004848 (L-Cysteine)

Enzymes

Transporters