Cannabis Compound Database: Showing Compound Card for L-Methionine (CDB004858)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (23)transporters (1) Show 35 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:44:03 UTC

Updated at

2020-12-07 19:11:07 UTC

CannabisDB ID

CDB004858

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Methionine

Description

L-Methionine, also known as acimethin or H-met-H, belongs to the class of organic compounds known as methionine and derivatives. Methionine and derivatives are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. The L-enantiomer of methionine. L-Methionine is a drug which is used for protein synthesis including the formation of same, l-homocysteine, l-cysteine, taurine, and sulfate. L-Methionine is a very strong basic compound (based on its pKa). L-Methionine exists in all living species, ranging from bacteria to humans. Outside of the human body, L-Methionine is found, on average, in the highest concentration within a few different foods, such as milk (cow), beluga whales, and smelts and in a lower concentration in white cabbages, wax gourds, and coconuts. L-Methionine has also been detected, but not quantified in, several different foods, such as pepper (c. chinense), acerola, grass pea, oxheart cabbages, and sherries. This could make L-methionine a potential biomarker for the consumption of these foods. L-Methionine is a potentially toxic compound. L-Methionine, with regard to humans, has been found to be associated with several diseases such as autism, leukemia, obesity, and heart failure; L-methionine has also been linked to the inborn metabolic disorder celiac disease. L-Methionine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-4-(methylsulfanyl)butanoic acid	ChEBI
(S)-2-Amino-4-(methylthio)butanoic acid	ChEBI
(S)-2-Amino-4-(methylthio)butyric acid	ChEBI
(S)-Methionine	ChEBI
L-(-)-Methionine	ChEBI
L-alpha-Amino-gamma-methylmercaptobutyric acid	ChEBI
L-Methionin	ChEBI
M	ChEBI
Met	ChEBI
METHIONINE	ChEBI
L-2-Amino-4methylthiobutyric acid	Kegg
L-Methionine Z	Kegg
(2S)-2-Amino-4-(methylsulfanyl)butanoate	Generator
(2S)-2-Amino-4-(methylsulphanyl)butanoate	Generator
(2S)-2-Amino-4-(methylsulphanyl)butanoic acid	Generator
(S)-2-Amino-4-(methylthio)butanoate	Generator
(S)-2-Amino-4-(methylthio)butyrate	Generator
L-a-Amino-g-methylmercaptobutyrate	Generator
L-a-Amino-g-methylmercaptobutyric acid	Generator
L-alpha-Amino-gamma-methylmercaptobutyrate	Generator
L-Α-amino-γ-methylmercaptobutyrate	Generator
L-Α-amino-γ-methylmercaptobutyric acid	Generator
L-2-Amino-4methylthiobutyrate	Generator
(L)-Methionine	HMDB
(S)-(+)-Methionine	HMDB
(S)-2-Amino-4-(methylthio)-butanoate	HMDB
(S)-2-Amino-4-(methylthio)-butanoic acid	HMDB
2-Amino-4-(methylthio)butyrate	HMDB
2-Amino-4-(methylthio)butyric acid	HMDB
2-Amino-4-methylthiobutanoate	HMDB
2-Amino-4-methylthiobutanoic acid	HMDB
a-Amino-g-methylmercaptobutyrate	HMDB
a-Amino-g-methylmercaptobutyric acid	HMDB
Acimethin	HMDB
alpha-Amino-alpha-aminobutyric acid	HMDB
alpha-Amino-gamma-methylmercaptobutyrate	HMDB
alpha-Amino-gamma-methylmercaptobutyric acid	HMDB
Cymethion	HMDB
g-Methylthio-a-aminobutyrate	HMDB
g-Methylthio-a-aminobutyric acid	HMDB
gamma-Methylthio-alpha-aminobutyrate	HMDB
gamma-Methylthio-alpha-aminobutyric acid	HMDB
H-Met-H	HMDB
H-Met-OH	HMDB
L(-)-Amino-alpha-amino-alpha-aminobutyric acid	HMDB
L(-)-Amino-gamma-methylthiobutyric acid	HMDB
L-2-Amino-4-(methylthio)butyric acid	HMDB
L-2-Amino-4-methylthiobutyric acid	HMDB
L-a-Amino-g-methylthiobutyrate	HMDB
L-a-Amino-g-methylthiobutyric acid	HMDB
L-alpha-Amino-gamma-methylthiobutyrate	HMDB
L-alpha-Amino-gamma-methylthiobutyric acid	HMDB
L-gamma-Methylthio-alpha-aminobutyric acid	HMDB
L-Methioninum	HMDB
Liquimeth	HMDB
Mepron	HMDB
Methilanin	HMDB
Methioninum	HMDB
Metionina	HMDB
Neo-methidin	HMDB
Poly-L-methionine	HMDB
Polymethionine	HMDB
S-Methionine	HMDB
S-Methyl-L-homocysteine	HMDB
Toxin war	HMDB
L-Isomer methionine	HMDB
Methionine, L-isomer	HMDB
Pedameth	HMDB
Methionine, L isomer	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-BETA,BETA-carotene-3,3'-diol	ChEBI
Bo-xan	ChEBI
e 161b	ChEBI
Xanthophyll	ChEBI
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3'-diol	Generator
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3'-diol	Generator

Chemical Formula

C₅H₁₁NO₂S

Average Molecular Weight

149.21

Monoisotopic Molecular Weight

149.051

IUPAC Name

(2S)-2-amino-4-(methylsulfanyl)butanoic acid

Traditional Name

L-methionine

CAS Registry Number

63-68-3

SMILES

CSCC[C@H](N)C(O)=O

InChI Identifier

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI Key

FFEARJCKVFRZRR-BYPYZUCNSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as methionine and derivatives. Methionine and derivatives are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Methionine and derivatives

Alternative Parents

Substituents

Methionine or derivatives
Alpha-amino acid
L-alpha-amino acid
Thia fatty acid
Fatty acid
Fatty acyl
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Thioether
Sulfenyl compound
Dialkylthioether
Amine
Organic oxygen compound
Primary amine
Organosulfur compound
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Primary aliphatic amine
Carbonyl group
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

aspartate family amino acid (CHEBI:16643 )
proteinogenic amino acid (CHEBI:16643 )
L-alpha-amino acid (CHEBI:16643 )
methionine (CHEBI:16643 )
Common amino acids (C00073 )

Ontology

Physiological effect

Health effect:

Health condition:

Blood and lymphatic system disorders:

Anemia

Cardiac disorders:

Heart failure

Cancer:

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Role

Indirect biological role:

Industrial application:

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	284 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	56.6 mg/mL	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	-1.87	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-1.8	ALOGPS
logP	-2.2	ChemAxon
logS	-0.8	ALOGPS
pKa (Strongest Acidic)	2.53	ChemAxon
pKa (Strongest Basic)	9.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	37.59 m³·mol⁻¹	ChemAxon
Polarizability	15.5 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Methionine, 2 TMS, GC-MS Spectrum	splash10-004i-0920000000-945c85aa7c9f5eb2dfbb	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-004i-0910000000-b837ee0f4413856560f1	Spectrum
GC-MS	L-Methionine, 2 TMS, GC-MS Spectrum	splash10-00b9-7910000000-5a1558fbb2f5e86edc9b	Spectrum
GC-MS	L-Methionine, 1 TMS, GC-MS Spectrum	splash10-0udi-1900000000-1a97567ce4f25c4e8263	Spectrum
GC-MS	L-Methionine, 2 TMS, GC-MS Spectrum	splash10-004i-0910000000-1b0477118cb20549bf4d	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-004i-0920000000-8ffae5d87508e0704903	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-004i-0920000000-945c85aa7c9f5eb2dfbb	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-004i-0910000000-b837ee0f4413856560f1	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-01bc-2692000000-c6a4af434abaeea2de87	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-00b9-7910000000-5a1558fbb2f5e86edc9b	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-0udi-1900000000-1a97567ce4f25c4e8263	Spectrum
GC-MS	L-Methionine, non-derivatized, GC-MS Spectrum	splash10-004i-0910000000-1b0477118cb20549bf4d	Spectrum
Predicted GC-MS	L-Methionine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0mbd-9200000000-77e5cfb78936ad02d71c	Spectrum
Predicted GC-MS	L-Methionine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00di-9510000000-c03dec8575710eed861e	Spectrum
Predicted GC-MS	L-Methionine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Methionine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Methionine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Methionine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0uea-1900000000-b991859b2c5bed6592a8	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-08fr-9000000000-66855ace60e59837f131	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-08fr-9000000000-56a567791c824c6a9da6	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0fe0-0900000000-d680295f21b2e2b40366	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0006-9000000000-062d3540db4db22da836	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-84467513e2c9ec1a6851	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-88dc2bebb198eea550ef	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0920000000-b444ad79abeb16acde43	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-6e24a8df417e5f3db58c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-c60ef880eb9a816a274b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-a7b7d1a3481c0c691a5b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0900000000-9156f088f4cc9eafa892	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0002-9200000000-f78ba2aab8d5a0e0b135	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0002-9000000000-e7b819fd2d0ac3862860	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0002-9000000000-b61396e720381bd5ff85	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0002-9000000000-b61396e720381bd5ff85	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0udi-0900000000-c3557cb41fd6fe268819	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0udi-6900000000-6bf5af2d1c561013948a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-08fr-9000000000-63c9b1c138f9a27490e5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-03di-9000000000-e133c47b0efe4992589f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-03di-9000000000-dee78b4f34f8732fedb0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-0udi-0900000000-d3f03ff5e8eacc8b6c8e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-0udi-0900000000-e0dd5ff44b7962f6a2d2	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-2900000000-305916dde72c899993b6	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-9800000000-47e0a34a2ec02bd762bf	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Betaine Metabolism
Methionine Metabolism
Transcription/Translation	Not Available	Not Available
Spermidine and Spermine Biosynthesis		Not Available
Glycine and Serine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Methionine synthase	MTR	1q43	Q99707	details
Methylenetetrahydrofolate reductase	MTHFR	1p36.3	P42898	details
Tyrosine aminotransferase	TAT	16q22.1	P17735	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
Arsenite methyltransferase	AS3MT	10q24.32	Q9HBK9	details
Indolethylamine N-methyltransferase	INMT	7p14.3	O95050	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
Methionine synthase reductase	MTRR	5p15.31	Q9UBK8	details
Kynurenine--oxoglutarate transaminase 1	CCBL1	9q34.11	Q16773	details
Mitochondrial peptide methionine sulfoxide reductase	MSRA	8p23.1	Q9UJ68	details
Betaine--homocysteine S-methyltransferase 1	BHMT	5q14.1	Q93088	details
Methionine--tRNA ligase, cytoplasmic	MARS	12q13	P56192	details
Glutamine synthetase	GLUL	1q31	P15104	details
Lipoyl synthase, mitochondrial	LIAS	4p14	O43766	details
Methionine adenosyltransferase 2 subunit beta	MAT2B		Q9NZL9	details
S-methylmethionine--homocysteine S-methyltransferase BHMT2	BHMT2	5q13	Q9H2M3	details
Methionine aminopeptidase 2	METAP2	12q22	P50579	details
L-amino-acid oxidase	IL4I1	19q13.3-q13.4	Q96RQ9	details
Kynurenine--oxoglutarate transaminase 3	CCBL2	1p22.2	Q6YP21	details
Methionine-R-sulfoxide reductase B2, mitochondrial	MSRB2	10p12	Q9Y3D2	details
Methionine-R-sulfoxide reductase B3	MSRB3	12q14.3	Q8IXL7	details
Methionine--tRNA ligase, mitochondrial	MARS2	2q33.1	Q96GW9	details
Methionine-R-sulfoxide reductase B1	MSRB1	16p13.3	Q9NZV6	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Methionine synthase	MTR	1q43	Q99707	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
Methionine synthase reductase	MTRR	5p15.31	Q9UBK8	details
Betaine--homocysteine S-methyltransferase 1	BHMT	5q14.1	Q93088	details
Lipoyl synthase, mitochondrial	LIAS	4p14	O43766	details
S-methylmethionine--homocysteine S-methyltransferase BHMT2	BHMT2	5q13	Q9H2M3	details
Methionine-R-sulfoxide reductase B2, mitochondrial	MSRB2	10p12	Q9Y3D2	details
Methionine-R-sulfoxide reductase B3	MSRB3	12q14.3	Q8IXL7	details
Methionine-R-sulfoxide reductase B1	MSRB1	16p13.3	Q9NZV6	details

Receptors

Not Available

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Methionine-R-sulfoxide reductase B2, mitochondrial	MSRB2	10p12	Q9Y3D2	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000696

DrugBank ID

DB00134

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

16643

References

General References

Not Available

Only showing the first 10 proteins. There are 35 proteins in total.

Show All

Enzymes

Enzyme Details

1. Methionine synthase

General function:: Involved in cobalamin binding
Specific function:: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Gene Name:: MTR
Uniprot ID:: Q99707
Molecular weight:: 140525.91

Enzyme Details

2. Methylenetetrahydrofolate reductase

General function:: Involved in methylenetetrahydrofolate reductase (NADPH) activity
Specific function:: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Gene Name:: MTHFR
Uniprot ID:: P42898
Molecular weight:: 74595.895

Enzyme Details

3. Tyrosine aminotransferase

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Gene Name:: TAT
Uniprot ID:: P17735
Molecular weight:: 50398.895

Enzyme Details

4. S-adenosylmethionine synthase isoform type-2

General function:: Involved in methionine adenosyltransferase activity
Specific function:: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:: MAT2A
Uniprot ID:: P31153
Molecular weight:: 43660.37

Enzyme Details

5. Arsenite methyltransferase

General function:: Involved in methyltransferase activity
Specific function:: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).
Gene Name:: AS3MT
Uniprot ID:: Q9HBK9
Molecular weight:: 41747.49

Enzyme Details

6. Indolethylamine N-methyltransferase

General function:: Involved in methyltransferase activity
Specific function:: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.
Gene Name:: INMT
Uniprot ID:: O95050
Molecular weight:: 28833.695

Enzyme Details

7. S-adenosylmethionine synthase isoform type-1

General function:: Involved in methionine adenosyltransferase activity
Specific function:: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:: MAT1A
Uniprot ID:: Q00266
Molecular weight:: 43647.6

Enzyme Details

8. Methionine synthase reductase

General function:: Involved in oxidoreductase activity
Specific function:: Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state.
Gene Name:: MTRR
Uniprot ID:: Q9UBK8
Molecular weight:: 77672.995

Enzyme Details

9. Kynurenine--oxoglutarate transaminase 1

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Gene Name:: CCBL1
Uniprot ID:: Q16773
Molecular weight:: 47874.765

Enzyme Details

10. Mitochondrial peptide methionine sulfoxide reductase

General function:: Involved in oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Specific function:: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Gene Name:: MSRA
Uniprot ID:: Q9UJ68
Molecular weight:: 21737.41

Transporters

Enzyme Details

1. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 35 proteins in total.

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Showing Compound Card for L-Methionine (CDB004858)

Structure for CDB004858 (L-Methionine)

Enzymes

Transporters