| Identification |
|---|
| HMDB Protein ID
| CDBP00495 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mitochondrial peptide methionine sulfoxide reductase |
| Description
| Not Available |
| Synonyms
|
- PMSR
- Peptide Met(O) reductase
- Peptide-methionine (S)-S-oxide reductase
- Protein-methionine-S-oxide reductase
|
| Gene Name
| MSRA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| Specific Function
| Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
|
| GO Classification
|
| Biological Process |
| aging |
| methionine metabolic process |
| response to oxidative stress |
| cellular protein modification process |
| Cellular Component |
| mitochondrion |
| nucleus |
| membrane |
| Function |
| oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| catalytic activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| oxidoreductase activity |
| Molecular Function |
| peptide-methionine (S)-S-oxide reductase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| oxidation reduction |
| protein metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p23.1 |
| SNPs
| MSRA |
| Gene Sequence
|
>708 bp
ATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTC
CCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGG
AAGGAACAGACCCCTGTAGCGGCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCT
TTCCCAGAGGGAACACAGATGGCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGG
AAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCAAGTTGGTTTTGCAGGAGGCTATACT
TCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAAAACTGGCCATGCAGAAGTCGTCCGA
GTGGTGTACCAGCCAGAACACATGAGTTTTGAGGAACTGCTCAAGGTCTTCTGGGAGAAT
CACGACCCGACCCAAGGTATGCGCCAGGGGAACGACCATGGCACTCAGTACCGCTCGGCC
ATCTACCCGACCTCTGCCAAGCAAATGGAGGCAGCCCTGAGCTCCAAAGAGAACTACCAA
AAGGTTCTTTCAGAGCACGGCTTCGGCCCCATCACTACCGACATCCGGGAGGGACAGACT
TTCTACTATGCGGAAGACTACCACCAGCAGTACCTGAGCAAGAACCCCAATGGCTACTGC
GGCCTTGGGGGCACCGGCGTGTCCTGCCCAGTGGGTATTAAAAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 235 |
| Molecular Weight
| 21737.41 |
| Theoretical pI
| 7.592 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peptide methionine sulfoxide reductase
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEP
FPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVR
VVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQ
KVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK
|
| External Links |
|---|
| GenBank ID Protein
| 6136945 |
| UniProtKB/Swiss-Prot ID
| Q9UJ68 |
| UniProtKB/Swiss-Prot Entry Name
| MSRA_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ242973 |
| GeneCard ID
| MSRA |
| GenAtlas ID
| MSRA |
| HGNC ID
| HGNC:7377 |
| References |
|---|
| General References
| Not Available |