Identification
HMDB Protein ID CDBP04334
Secondary Accession Numbers Not Available
Name Methionine-R-sulfoxide reductase B3
Description Not Available
Synonyms
  1. MsrB3
Gene Name MSRB3
Protein Type Enzyme
Biological Properties
General Function Involved in peptide-methionine-(S)-S-oxide reductase activity
Specific Function Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
GO Classification
Biological Process
protein repair
Cellular Component
endoplasmic reticulum
mitochondrion
Function
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
catalytic activity
oxidoreductase activity, acting on a sulfur group of donors
oxidoreductase activity
peptide-methionine-(s)-s-oxide reductase activity
Molecular Function
peptide-methionine (R)-S-oxide reductase activity
metal ion binding
zinc ion binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Isoform 2:Endoplasmic reticulum
Pathways
Gene Properties
Chromosome Location 12
Locus 12q14.3
SNPs MSRB3
Gene Sequence
>558 bp
ATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCC
TGTGGGCTTCCCTCAGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAG
CAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACC
GAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTT
GTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCT
TCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGG
ATGCACAGGGTGGAAACAAGCTGCTCTCAGTGTGGTGCTCACCTTGGGCACATTTTTGAT
GATGGGCCTCGTCCAACTGGGAAAAGATACTGCATAAATTCGGCTGCCTTGTCTTTTACA
CCTGCGGATAGCAGTGGCACCGCCGAGGGAGGCAGTGGGGTCGCCAGCCCGGCCCAGGCA
GACAAAGCGGAGCTCTAG
Protein Properties
Number of Residues 185
Molecular Weight 20010.23
Theoretical pI 7.152
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Methionine-R-sulfoxide reductase B3, mitochondrial
MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGT
ESAFEGEYTHHKDPGIYKCVVCGTPLFKSETKFDSGSGWPSFHDVINSEAITFTDDFSYG
MHRVETSCSQCGAHLGHIFDDGPRPTGKRYCINSAALSFTPADSSGTAEGGSGVASPAQA
DKAEL
GenBank ID Protein 158259629
UniProtKB/Swiss-Prot ID Q8IXL7
UniProtKB/Swiss-Prot Entry Name MSRB3_HUMAN
PDB IDs Not Available
GenBank Gene ID AK293084
GeneCard ID MSRB3
GenAtlas ID MSRB3
HGNC ID HGNC:27375
References
General References Not Available