Cannabis Compound Database: Showing Compound Card for L-Arginine (CDB004846)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (22)transporters (4) Show 41 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:42:49 UTC

Updated at

2020-12-07 19:11:05 UTC

CannabisDB ID

CDB004846

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Arginine

Description

Arginine or l-arginine, abbreviated Arg or R, is an essential amino acid that is physiologically active in the L-form. In mammals, arginine is formally classified as a semi-essential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. Pre-term infants are unable to effectively synthesize arginine, making it nutritionally essential for them. Adults, however, synthesize arginine from glutamate via citrulline. Arginine is a basic amino acid as its side chain contains a positively charged guanidinium group, which is highly polar, at the end of a hydrophobic¬†aliphatic¬†hydrocarbon chain. With a pKa of 12.48, the guanidinium group is positively charged in neutral, acidic, and even most basic environments. Because of the conjugation between the double bond and the nitrogen lone pairs, the positive charge is delocalized. This group is able to form multiple H-bonds. L-Arginine is an amino acid that has numerous functions in the body. It helps dispose of ammonia, is a precursor of nitric oxide, creatine, L-glutamate, and L-proline, and it can be converted into glucose and glycogen if needed. In large doses, L-arginine also stimulates the release of the hormones, growth hormone and prolactin. Arginine is a known inducer of mTOR (mammalian target of rapamycin) and is responsible for inducing protein synthesis through the mTOR pathway. mTOR inhibition by rapamycin partially reduces arginine-induced protein synthesis (PMID: 20841502 ). Catabolic disease states such as sepsis, injury, and cancer cause an increase in arginine utilization, which can exceed normal body production, leading to arginine depletion. Arginine also activates AMP kinase (AMPK) which then stimulates skeletal muscle fatty acid oxidation and muscle glucose uptake, thereby increasing insulin secretion by pancreatic beta-cells (PMID: 21311355 ). Arginine is found in plant and animal proteins, such as dairy products, meat, poultry, fish, and nuts. While many studies suggested that plant based protein-rich foods like soy protein, which contain less arginine, reduced cardiovascular risk compared to arginine rich foods like animal proteins, other studies have found little or null effects (PMID: 20042191 ). Arginine is one of the amino acids that are known in cannabis plant (PMID: 6991645 ). L-Arginine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-5-(carbamimidamido)pentanoic acid	ChEBI
(2S)-2-Amino-5-guanidinopentanoic acid	ChEBI
(S)-2-Amino-5-guanidinopentanoic acid	ChEBI
(S)-2-Amino-5-guanidinovaleric acid	ChEBI
Arg	ChEBI
Arginine	ChEBI
L-(+)-Arginine	ChEBI
L-Arg	ChEBI
L-Arginin	ChEBI
R	ChEBI
(2S)-2-Amino-5-(carbamimidamido)pentanoate	Generator
(2S)-2-Amino-5-guanidinopentanoate	Generator
(S)-2-Amino-5-guanidinopentanoate	Generator
(S)-2-Amino-5-guanidinovalerate	Generator
(S)-2-Amino-5-[(aminoiminomethyl)amino]-pentanoate	HMDB
(S)-2-Amino-5-[(aminoiminomethyl)amino]-pentanoic acid	HMDB
(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate	HMDB
(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid	HMDB
2-Amino-5-guanidinovalerate	HMDB
2-Amino-5-guanidinovaleric acid	HMDB
5-[(Aminoiminomethyl)amino]-L-norvaline	HMDB
L-a-Amino-D-guanidinovalerate	HMDB
L-a-Amino-D-guanidinovaleric acid	HMDB
L-alpha-Amino-delta-guanidinovalerate	HMDB
L-alpha-Amino-delta-guanidinovaleric acid	HMDB
N5-(Aminoiminomethyl)-L-ornithine	HMDB
DL-Arginine acetate, monohydrate	HMDB
L-Isomer arginine	HMDB
Monohydrate DL-arginine acetate	HMDB
L Arginine	HMDB
Arginine, L isomer	HMDB
Arginine, L-isomer	HMDB
Hydrochloride, arginine	HMDB
Arginine hydrochloride	HMDB
DL Arginine acetate, monohydrate	HMDB

Chemical Formula

C₆H₁₄N₄O₂

Average Molecular Weight

174.2

Monoisotopic Molecular Weight

174.1117

IUPAC Name

(2S)-2-amino-5-carbamimidamidopentanoic acid

Traditional Name

L-arginine

CAS Registry Number

74-79-3

SMILES

N[C@@H](CCCNC(N)=N)C(O)=O

InChI Identifier

InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

InChI Key

ODKSFYDXXFIFQN-BYPYZUCNSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Fatty acid
Guanidine
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Carboximidamide
Propargyl-type 1,3-dipolar organic compound
Organic 1,3-dipolar compound
Amine
Hydrocarbon derivative
Organic oxide
Primary amine
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Primary aliphatic amine
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:16467 )
L-alpha-amino acid (CHEBI:16467 )
arginine (CHEBI:16467 )
glutamine family amino acid (CHEBI:16467 )
Common amino acids (C00062 )

Ontology

Heart failure

Cancer:

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Role

Industrial application:

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	222 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	182 mg/mL at 25 °C	Human Metabolome Project
logP	-4.20	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-3.5	ALOGPS
logP	-3.2	ChemAxon
logS	-1.9	ALOGPS
pKa (Strongest Acidic)	2.41	ChemAxon
pKa (Strongest Basic)	12.41	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	125.22 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	53.92 m³·mol⁻¹	ChemAxon
Polarizability	17.8 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Arginine, 3 TMS, GC-MS Spectrum	splash10-0a4i-1910000000-0191c1a63652c493660b	Spectrum
GC-MS	L-Arginine, 3 TMS, GC-MS Spectrum	splash10-00di-9810000000-eb6eb73302b678cf0a24	Spectrum
GC-MS	L-Arginine, 2 TMS, GC-MS Spectrum	splash10-00di-9700000000-e47b41cff0e873f53932	Spectrum
GC-MS	L-Arginine, 3 TMS, GC-MS Spectrum	splash10-0a4i-1920000000-8ae5af11398835d26bed	Spectrum
GC-MS	L-Arginine, non-derivatized, GC-MS Spectrum	splash10-0a4i-1910000000-0191c1a63652c493660b	Spectrum
GC-MS	L-Arginine, non-derivatized, GC-MS Spectrum	splash10-00di-9810000000-eb6eb73302b678cf0a24	Spectrum
GC-MS	L-Arginine, non-derivatized, GC-MS Spectrum	splash10-00di-9700000000-e47b41cff0e873f53932	Spectrum
GC-MS	L-Arginine, non-derivatized, GC-MS Spectrum	splash10-0a4i-1920000000-8ae5af11398835d26bed	Spectrum
GC-MS	L-Arginine, non-derivatized, GC-MS Spectrum	splash10-0udi-0900000000-afc3ca93f8fbf54ec9f4	Spectrum
Predicted GC-MS	L-Arginine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-9100000000-60db59de76b9a9b5bfc8	Spectrum
Predicted GC-MS	L-Arginine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004i-8900000000-f47c4f9480612fdbc962	Spectrum
Predicted GC-MS	L-Arginine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Arginine, TBDMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0fk9-0946231100-3d57d2304dcb33feab3f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-000i-0900000000-5b6dd6fb263ea09289fc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-dfe35b3438d19320d8cb	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0900000000-f666ab7e5354bce67a2e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03kd-0977452210-046c4b70bd0ec351c41d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-014i-9000000000-2f51e43e530976d63633	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-b9ebb7ebccee1a313888	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0900000000-5379b6fb6ea2313101f9	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-001i-0900000000-835751d54af24bd337e7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-001i-0900000000-2d2b5fd7617ccb227bb1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-001i-0900000000-dfe35b3438d19320d8cb	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-00di-0900000000-f666ab7e5354bce67a2e	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-001i-0900000000-b9ebb7ebccee1a313888	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-00di-0900000000-5379b6fb6ea2313101f9	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-001i-0900000000-835751d54af24bd337e7	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-001i-0900000000-2d2b5fd7617ccb227bb1	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-001i-0900000000-8e090b4f0a569ec011b3	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-001i-0900000000-647e6324d4041e9d5cc1	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9000000000-d866a7f7b1bf575941ee	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-001i-1900000000-c3a3ef3d4f3627781019	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-00di-3900000000-8c82418f7b35a97fb9b3	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-00di-9000000000-19b62da79866318c52dd	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-00di-9000000000-64b046d21bdcbb8d5923	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0900000000-e07b937b6867d1f62293	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-87ab853583aab2973cfb	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Urea Cycle
Transcription/Translation	Not Available	Not Available
Arginine and Proline Metabolism
Glycine and Serine Metabolism
Prolidase Deficiency (PD)		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Arginase-1	ARG1	6q23	P05089	details
Glycine amidinotransferase, mitochondrial	GATM	15q21.1	P50440	details
Arginine--tRNA ligase, cytoplasmic	RARS	5q35.1	P54136	details
Argininosuccinate synthase	ASS1	9q34.1	P00966	details
Protein-arginine deiminase type-4	PADI4	1p36.13	Q9UM07	details
Protein-arginine deiminase type-3	PADI3	1p36.13	Q9ULW8	details
Argininosuccinate lyase	ASL	7q11.21	P04424	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Ecto-ADP-ribosyltransferase 3	ART3	4p15.1-p14	Q13508	details
Ecto-ADP-ribosyltransferase 5	ART5	11p15.4	Q96L15	details
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	11p15	P52961	details
Ecto-ADP-ribosyltransferase 4	ART4	12p13-p12	Q93070	details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Nitric oxide synthase, endothelial	NOS3	7q36	P29474	details
Arginase-2, mitochondrial	ARG2	14q24.1	P78540	details
Arginine decarboxylase	ADC	1p35.1	Q96A70	details
High affinity cationic amino acid transporter 1	SLC7A1	13q12-q14	P30825	details
Probable arginine--tRNA ligase, mitochondrial	RARS2	6q16.1	Q5T160	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
NOS1 mutant	NOS1	12q24.2-q24.31	B3VK56	details
[Protein ADP-ribosylarginine] hydrolase	ADPRH	3q13.31-q13.33	P54922	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Y+L amino acid transporter 1	SLC7A7	14q11.2	Q9UM01	details
High affinity cationic amino acid transporter 1	SLC7A1	13q12-q14	P30825	details
Y+L amino acid transporter 2	SLC7A6	16q22.1	Q92536	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Arginase-1	ARG1	6q23	P05089	details
Protein-arginine deiminase type-4	PADI4	1p36.13	Q9UM07	details
Protein-arginine deiminase type-3	PADI3	1p36.13	Q9ULW8	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Nitric oxide synthase, endothelial	NOS3	7q36	P29474	details
Arginase-2, mitochondrial	ARG2	14q24.1	P78540	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
NOS1 mutant	NOS1	12q24.2-q24.31	B3VK56	details
[Protein ADP-ribosylarginine] hydrolase	ADPRH	3q13.31-q13.33	P54922	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Protein-arginine deiminase type-4	PADI4	1p36.13	Q9UM07	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000517

DrugBank ID

DB00125

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

16467

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
Bauchart-Thevret C, Cui L, Wu G, Burrin DG: Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E899-909. doi: 10.1152/ajpendo.00068.2010. Epub 2010 Sep 14. [PubMed:20841502 ]
Linden KC, Wadley GD, Garnham AP, McConell GK: Effect of l-arginine infusion on glucose disposal during exercise in humans. Med Sci Sports Exerc. 2011 Sep;43(9):1626-34. doi: 10.1249/MSS.0b013e318212a317. [PubMed:21311355 ]
Vega-Lopez S, Matthan NR, Ausman LM, Harding SV, Rideout TC, Ai M, Otokozawa S, Freed A, Kuvin JT, Jones PJ, Schaefer EJ, Lichtenstein AH: Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults. Atherosclerosis. 2010 Jun;210(2):555-62. doi: 10.1016/j.atherosclerosis.2009.12.002. Epub 2009 Dec 5. [PubMed:20042191 ]

Only showing the first 10 proteins. There are 41 proteins in total.

Show All

Enzymes

Enzyme Details

1. Arginase-1

General function:: Involved in arginase activity
Specific function:: Not Available
Gene Name:: ARG1
Uniprot ID:: P05089
Molecular weight:: 34734.655

Enzyme Details

2. Glycine amidinotransferase, mitochondrial

General function:: Amino acid transport and metabolism
Specific function:: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Name:: GATM
Uniprot ID:: P50440
Molecular weight:: 48455.01

Enzyme Details

3. Arginine--tRNA ligase, cytoplasmic

General function:: Involved in nucleotide binding
Specific function:: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
Gene Name:: RARS
Uniprot ID:: P54136
Molecular weight:: 75378.295

Enzyme Details

4. Argininosuccinate synthase

General function:: Involved in argininosuccinate synthase activity
Specific function:: Not Available
Gene Name:: ASS1
Uniprot ID:: P00966
Molecular weight:: 46530.055

Enzyme Details

5. Protein-arginine deiminase type-4

General function:: Involved in protein-arginine deiminase activity
Specific function:: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
Gene Name:: PADI4
Uniprot ID:: Q9UM07
Molecular weight:: 74078.65

Enzyme Details

6. Protein-arginine deiminase type-3

General function:: Involved in protein-arginine deiminase activity
Specific function:: Catalyzes the deimination of arginine residues of proteins.
Gene Name:: PADI3
Uniprot ID:: Q9ULW8
Molecular weight:: 74742.705

Enzyme Details

7. Argininosuccinate lyase

General function:: Involved in argininosuccinate lyase activity
Specific function:: Not Available
Gene Name:: ASL
Uniprot ID:: P04424
Molecular weight:: 51657.505

Enzyme Details

8. NAD-dependent protein deacetylase sirtuin-6

General function:: Involved in zinc ion binding
Specific function:: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Gene Name:: SIRT6
Uniprot ID:: Q8N6T7
Molecular weight:: 36064.295

Enzyme Details

9. Ecto-ADP-ribosyltransferase 3

General function:: Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Specific function:: Not Available
Gene Name:: ART3
Uniprot ID:: Q13508
Molecular weight:: 43922.97

Enzyme Details

10. Ecto-ADP-ribosyltransferase 5

General function:: Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Specific function:: Not Available
Gene Name:: ART5
Uniprot ID:: Q96L15
Molecular weight:: 32053.48

Transporters

Enzyme Details

1. Nitric oxide synthase, inducible

General function:: Involved in oxidoreductase activity
Specific function:: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:: NOS2
Uniprot ID:: P35228
Molecular weight:: 131116.3

Enzyme Details

2. Y+L amino acid transporter 1

General function:: Involved in transport
Specific function:: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes
Gene Name:: SLC7A7
Uniprot ID:: Q9UM01
Molecular weight:: 55990.0

Enzyme Details

3. High affinity cationic amino acid transporter 1

General function:: Involved in transport
Specific function:: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor
Gene Name:: SLC7A1
Uniprot ID:: P30825
Molecular weight:: 67637.6

Enzyme Details

4. Y+L amino acid transporter 2

General function:: Involved in transport
Specific function:: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells
Gene Name:: SLC7A6
Uniprot ID:: Q92536
Molecular weight:: 56826.9

Only showing the first 10 proteins. There are 41 proteins in total.

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Showing Compound Card for L-Arginine (CDB004846)

Structure for CDB004846 (L-Arginine)

Enzymes

Transporters